Gene Page: PITX1

Summary
GeneID  5307
Symbol  PITX1
Synonyms  BFT|POTX|PTX1
Description  paired-like homeodomain 1
See related  HGNC:9004|MIM:602149|Ensembl:ENSG00000069011|HPRD:03688|
Locus tag  -
Gene type  protein-coding
Map location  5q31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0032 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TNK20.790.83
ZBTB470.770.80
CASKIN10.730.73
ACTN40.720.75
SPTBN40.720.74
MAP3K110.710.74
AATK0.700.73
SNAI30.690.72
TMEM184B0.690.70
MINK10.690.73
Top 10 negatively co-expressed genes
RPS7-0.56-0.61
FUNDC2-0.53-0.56
PFDN5-0.53-0.61
TPT1-0.52-0.62
C18orf32-0.52-0.55
PSMA6-0.51-0.53
ZNF32-0.51-0.57
PPP2R3C-0.51-0.54
ALG5-0.50-0.53
MRPL13-0.50-0.52
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIEA-
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0009653anatomical structure morphogenesisTAS9070926 
GO:0007275multicellular organismal developmentIEA-
GO:0021983pituitary gland developmentIEA-
GO:0051216cartilage developmentIEA-
GO:0035137hindlimb morphogenesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DVL3KIAA0208dishevelled, dsh homolog 3 (Drosophila)Two-hybridBioGRID16189514 
EGR1AT225 | G0S30 | KROX-24 | NGFI-A | TIS8 | ZIF-268 | ZNF225early growth response 1-HPRD,BioGRID10082522 
NEUROD1BETA2 | BHF-1 | NEUROD | bHLHa3neurogenic differentiation 1-HPRD9343431 
NR5A1AD4BP | ELP | FTZ1 | FTZF1 | SF-1 | SF1nuclear receptor subfamily 5, group A, member 1-HPRD,BioGRID10369682 
POU1F1GHF-1 | PIT1 | Pit-1POU class 1 homeobox 1-HPRD,BioGRID8755540 
RASAL1RASALRAS protein activator like 1 (GAP1 like)PITX1 interacts with RASAL1 promoter.BIND15960973 
RBPMSHERMESRNA binding protein with multiple splicingTwo-hybridBioGRID16189514 
RHOXF2PEPP-2 | PEPP2 | THG1Rhox homeobox family, member 2Two-hybridBioGRID16189514 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-199139201A,m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-30-5p9439501A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-363857863m8hsa-miR-363AUUGCACGGUAUCCAUCUGUAA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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