Gene Page

Gene Page: SSH1

Summary

GeneID

54434

Symbol

SSH1

Synonyms

FLJ38102|KIAA1298|SSH-1

Description

slingshot homolog 1 (Drosophila)

Locus tag

Gene type

protein-coding

Map location

12q24.11

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003779

actin binding

IDA

11832213

GO:0005515

protein binding

IPI

17350576

GO:0004725

protein tyrosine phosphatase activity

IEA

GO:0016787

hydrolase activity

IEA

GO:0008138

protein tyrosine/serine/threonine phosphatase activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000902

cell morphogenesis

IMP

14645219

GO:0006470

protein amino acid dephosphorylation

IMP

11832213 |14645219

GO:0030036

actin cytoskeleton organization

IMP

11832213

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0042995

cell projection

IEA

axon (GO term level: 4)

GO:0005856

cytoskeleton

IEA

GO:0005737

cytoplasm

IDA

14645219

GO:0005886

plasma membrane

IDA

14645219

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTB	PS1TP5BP1	actin, beta	Reconstituted Complex	BioGRID	11832213
CFL1	CFL	cofilin 1 (non-muscle)	Unphosphorylated SSH-1L interacts with and dephosphorylates cofilin.	BIND	15660133
DSTN	ACTDP \| ADF \| bA462D18.2	destrin (actin depolymerizing factor)	Biochemical Activity	BioGRID	11832213
LIMK1	LIMK	LIM domain kinase 1	SSH-1S interacts with LIMK1.	BIND	15660133
LIMK1	LIMK	LIM domain kinase 1	SSH-1L interacts with and dephosphorylates LIMK1.	BIND	15660133
LIMK2	-	LIM domain kinase 2	SSH-1L interacts with and dephosphorylates an unspecified isoform of LIMK2.	BIND	15660133
PAK4	-	p21 protein (Cdc42/Rac)-activated kinase 4	PAK4 interacts with and phosphorylates SSH-1L.	BIND	15660133
YWHAZ	KCIP-1 \| MGC111427 \| MGC126532 \| MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	SSH-1S interacts with 14-3-3-zeta.	BIND	15660133
YWHAZ	KCIP-1 \| MGC111427 \| MGC126532 \| MGC138156		SSH-1L interacts with 14-3-3-zeta.	BIND	15660133

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	429	435	m8	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.