Gene Page: DNAAF5
Summary ?
| GeneID | 54919 |
| Symbol | DNAAF5 |
| Synonyms | CILD18|HEATR2 |
| Description | dynein (axonemal) assembly factor 5 |
| Reference | MIM:614864|HGNC:HGNC:26013|Ensembl:ENSG00000164818|HPRD:07903|Vega:OTTHUMG00000151416 |
| Gene type | protein-coding |
| Map location | 7p22.3 |
| DEG p-value | DEG:Zhao_2015:p=5.75e-04:q=0.0926 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DEG:Zhao_2015 | RNA Sequencing analysis | Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder. |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ZSCAN18 | 0.82 | 0.83 |
| ARHGDIA | 0.81 | 0.80 |
| TAOK2 | 0.80 | 0.80 |
| OTUD5 | 0.80 | 0.78 |
| MARK2 | 0.80 | 0.79 |
| DNAJB12 | 0.80 | 0.79 |
| FKRP | 0.79 | 0.81 |
| C12orf53 | 0.79 | 0.78 |
| PIM3 | 0.79 | 0.80 |
| DDX54 | 0.79 | 0.79 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.64 | -0.54 |
| AF347015.31 | -0.61 | -0.51 |
| MT-CO2 | -0.60 | -0.51 |
| AF347015.8 | -0.57 | -0.49 |
| C1orf54 | -0.56 | -0.52 |
| AF347015.2 | -0.56 | -0.44 |
| MT-CYB | -0.55 | -0.46 |
| AF347015.33 | -0.55 | -0.46 |
| NOSTRIN | -0.54 | -0.44 |
| CLEC2B | -0.54 | -0.47 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005515 | protein binding | IPI | 17353931 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| BRF2 | BRFU | FLJ11052 | TFIIIB50 | BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like | Affinity Capture-MS | BioGRID | 17353931 |
| CASP4 | ICE(rel)II | ICEREL-II | ICH-2 | Mih1/TX | TX | caspase 4, apoptosis-related cysteine peptidase | Affinity Capture-MS | BioGRID | 17353931 |
| CIAO1 | CIA1 | WDR39 | cytosolic iron-sulfur protein assembly 1 homolog (S. cerevisiae) | Affinity Capture-MS | BioGRID | 17353931 |
| FEZ1 | - | fasciculation and elongation protein zeta 1 (zygin I) | Two-hybrid | BioGRID | 16169070 |
| GSTK1 | GST13 | glutathione S-transferase kappa 1 | Affinity Capture-MS | BioGRID | 17353931 |
| ILK | DKFZp686F1765 | P59 | integrin-linked kinase | Affinity Capture-MS | BioGRID | 17353931 |
| MAGEA6 | MAGE-3b | MAGE3B | MAGE6 | MGC52297 | melanoma antigen family A, 6 | Affinity Capture-MS | BioGRID | 17353931 |
| MAGED1 | DLXIN-1 | NRAGE | melanoma antigen family D, 1 | Affinity Capture-MS | BioGRID | 17353931 |
| PGRMC1 | HPR6.6 | MPR | progesterone receptor membrane component 1 | Affinity Capture-MS | BioGRID | 17353931 |
| PHLDA3 | TIH1 | pleckstrin homology-like domain, family A, member 3 | Affinity Capture-MS | BioGRID | 17353931 |
| PNKP | PNK | polynucleotide kinase 3'-phosphatase | Affinity Capture-MS | BioGRID | 17353931 |
| PTP4A3 | PRL-3 | PRL-R | PRL3 | protein tyrosine phosphatase type IVA, member 3 | Affinity Capture-MS | BioGRID | 17353931 |
| TSC22D1 | DKFZp686O19206 | MGC17597 | RP11-269C23.2 | TGFB1I4 | TSC22 | TSC22 domain family, member 1 | Affinity Capture-MS | BioGRID | 17353931 |
| ZBTB16 | PLZF | ZNF145 | zinc finger and BTB domain containing 16 | Two-hybrid | BioGRID | 16169070 |