Gene Page: PPP2R1B

Summary
GeneID  5519
Symbol  PPP2R1B
Synonyms  MGC26454|PR65B
Description  protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform
See related  HGNC:9303|MIM:603113|Ensembl:ENSG00000137713|HPRD:04384|
Locus tag  -
Gene type  protein-coding
Map location  11q23.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.006 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0232 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
GPER0.730.77
GGT50.720.72
TINAGL10.700.71
TBX20.700.68
BCAM0.700.69
HLA-E0.690.71
A4GALT0.690.71
C1QTNF10.690.69
SLC6A120.680.69
GIMAP50.680.65
Top 10 negatively co-expressed genes
HYLS1-0.63-0.64
FARSB-0.62-0.62
GNL3-0.62-0.66
AARSD1-0.62-0.65
UAP1-0.62-0.59
SUPV3L1-0.62-0.65
METTL6-0.62-0.59
SPATS2-0.61-0.63
GLOD4-0.61-0.62
EIF4E2-0.61-0.61
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003823antigen bindingISS-
GO:0005488bindingIEA-
GO:0005515protein bindingISS-
GO:0046982protein heterodimerization activityISS-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKAP9AKAP350 | AKAP450 | CG-NAP | HYPERION | KIAA0803 | MU-RMS-40.16A | PRKA9 | YOTIAOA kinase (PRKA) anchor protein (yotiao) 9-HPRD10358086 
ARL2ARFL2ADP-ribosylation factor-like 2-HPRD12912990 
CTTNBP2NLDKFZp547A023 | FLJ13278CTTNBP2 N-terminal likeAffinity Capture-MSBioGRID18782753 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)-HPRD,BioGRID11440634 
MOBKL32C4D | CGI-95 | MGC12264 | MOB1 | MOB3 | PREI3MOB1, Mps One Binder kinase activator-like 3 (yeast)Affinity Capture-MSBioGRID18782753 
PDCD10CCM3 | MGC1212 | MGC24477 | TFAR15programmed cell death 10Affinity Capture-MSBioGRID18782753 
PPP2CAPP2Ac | PP2CA | RP-Cprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoformAffinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		BioGRID12370081 |18782753 
A-beta subunit interacts with C-alpha subunit of PP2A. This interaction was modeled on a demonstrated interaction between human A-beta subunit and rabbit C-alpha subunit.BIND11313937 
PPP2CBPP2CBprotein phosphatase 2 (formerly 2A), catalytic subunit, beta isoformAffinity Capture-Western
Reconstituted Complex		BioGRID12370081 
PPP2R1AMGC786 | PR65Aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoformAffinity Capture-MSBioGRID18782753 
PPP2R2AB55-ALPHA | B55A | FLJ26613 | MGC52248 | PR52A | PR55Aprotein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform-HPRD,BioGRID1328247 
PPP2R2CB55-GAMMA | IMYPNO | IMYPNO1 | MGC33570 | PR52 | PR55Gprotein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoformAffinity Capture-MSBioGRID18782753 
PPP2R3BNY-REN-8 | PPP2R3L | PPP2R3LY | PR48protein phosphatase 2 (formerly 2A), regulatory subunit B'', betaAffinity Capture-Western
Reconstituted Complex		BioGRID12370081 
PPP2R5AB56A | MGC131915 | PR61Aprotein phosphatase 2, regulatory subunit B', alpha isoformAffinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		BioGRID12370081 |18782753 
PPP2R5CB56G | MGC23064 | PR61Gprotein phosphatase 2, regulatory subunit B', gamma isoform-HPRD11929880 
STK24MST-3 | MST3 | MST3B | STE20 | STK3serine/threonine kinase 24 (STE20 homolog, yeast)Affinity Capture-MSBioGRID18782753 
STK25DKFZp686J1430 | SOK1 | YSK1serine/threonine kinase 25 (STE20 homolog, yeast)Affinity Capture-MSBioGRID18782753 
STRNMGC125642 | SG2NAstriatin, calmodulin binding proteinAffinity Capture-MSBioGRID18782753 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-2241421491A,m8hsa-miR-224CAAGUCACUAGUGGUUCCGUUUA
miR-30-5p3813871Ahsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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