Gene Page

Gene Page: PPP5C

Summary

GeneID

5536

Symbol

PPP5C

Synonyms

FLJ36922|PP5|PPP5

Description

protein phosphatase 5, catalytic subunit

Locus tag

Gene type

protein-coding

Map location

19q13.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.7977

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004871

signal transducer activity

IMP

12761501

GO:0005506

iron ion binding

IEA

GO:0005515

protein binding

IPI

14764652

GO:0004722

protein serine/threonine phosphatase activity

TAS

7925273

GO:0004721

phosphoprotein phosphatase activity

IEA

GO:0016787

hydrolase activity

IEA

GO:0030145

manganese ion binding

IEA

GO:0046872

metal ion binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006350

transcription

TAS

7925273

GO:0006470

protein amino acid dephosphorylation

TAS

7925273

GO:0007067

mitosis

TAS

7925273

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB cascade

IMP

12761501

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005829

cytosol

IEA

GO:0005634

nucleus

TAS

7925273

GO:0005737

cytoplasm

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CDC16	APC6	cell division cycle 16 homolog (S. cerevisiae)	-	HPRD	9405394
CDC27	APC3 \| CDC27Hs \| D0S1430E \| D17S978E \| HNUC	cell division cycle 27 homolog (S. cerevisiae)	-	HPRD,BioGRID	9405394
CPNE1	COPN1 \| CPN1 \| MGC1142	copine I	-	HPRD	12522145
CPNE2	COPN2 \| CPN2 \| DKFZp686E06199 \| MGC16924	copine II	-	HPRD	12522145
CPNE4	COPN4 \| CPN4 \| MGC15604	copine IV	-	HPRD	12522145
CRY2	FLJ10332 \| HCRY2 \| KIAA0658 \| PHLL2	cryptochrome 2 (photolyase-like)	-	HPRD,BioGRID	9383998
CSE1L	CAS \| CSE1 \| MGC117283 \| MGC130036 \| MGC130037 \| XPO2	CSE1 chromosome segregation 1-like (yeast)	Two-hybrid	BioGRID	16169070
GNA12	MGC104623 \| MGC99644 \| NNX3 \| RMP \| gep	guanine nucleotide binding protein (G protein) alpha 12	-	HPRD,BioGRID	12176367
GNA13	G13 \| MGC46138	guanine nucleotide binding protein (G protein), alpha 13	GNA13 (alpha-13) interacts with PPP5C (PP5).	BIND	15735747
GNA13	G13 \| MGC46138	guanine nucleotide binding protein (G protein), alpha 13	-	HPRD,BioGRID	12176367
HSP90AA1	FLJ31884 \| HSP86 \| HSP89A \| HSP90A \| HSP90N \| HSPC1 \| HSPCA \| HSPCAL1 \| HSPCAL4 \| HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	-	HPRD	10400612
HSP90AA1			Hsp90 interacts with PP5. This interaction was modeled on a demonstrated interaction between human Hsp90 and PP5 from an unspecified species.	BIND	15664193
MAP3K5	ASK1 \| MAPKKK5 \| MEKK5	mitogen-activated protein kinase kinase kinase 5	-	HPRD,BioGRID	11689443
PPP2R1A	MGC786 \| PR65A	protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform	-	HPRD	11504734

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-137	333	340	1A,m8	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-365	245	251	m8	hsa-miR-365	UAAUGCCCCUAAAAAUCCUUAU
miR-504	371	377	1A	hsa-miR-504	AGACCCUGGUCUGCACUCUAU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.