Gene Page: NDUFAF7
Summary ?
| GeneID | 55471 |
| Symbol | NDUFAF7 |
| Synonyms | C2orf56|MidA|PRO1853 |
| Description | NADH:ubiquinone oxidoreductase complex assembly factor 7 |
| Reference | MIM:615898|HGNC:HGNC:28816|Ensembl:ENSG00000003509|HPRD:15180|Vega:OTTHUMG00000128468 |
| Gene type | protein-coding |
| Map location | 2p22.2 |
| Pascal p-value | 9.116E-6 |
| DMG | 1 (# studies) |
| eGene | Cerebellum |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
| LK:YES | Genome-wide Association Study | This data set included 99 genes mapped to the 22 regions. The 24 leading SNPs were also included in CV:Ripke_2013 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg25805189 | 2 | 37458826 | NDUFAF7 | 6.41E-9 | -0.014 | 3.35E-6 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| LRFN5 | 0.81 | 0.84 |
| TBC1D9 | 0.78 | 0.81 |
| TPST1 | 0.77 | 0.80 |
| ARMCX2 | 0.77 | 0.79 |
| TMEM65 | 0.77 | 0.81 |
| AAGAB | 0.77 | 0.80 |
| ARNTL2 | 0.77 | 0.82 |
| FAR2 | 0.77 | 0.76 |
| RAP1GDS1 | 0.76 | 0.76 |
| KCND2 | 0.76 | 0.84 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.2 | -0.53 | -0.46 |
| AC098691.2 | -0.53 | -0.57 |
| MT-CO2 | -0.51 | -0.45 |
| AF347015.8 | -0.51 | -0.45 |
| AF347015.26 | -0.50 | -0.44 |
| AF347015.33 | -0.50 | -0.42 |
| AF347015.18 | -0.50 | -0.46 |
| AF347015.21 | -0.49 | -0.41 |
| MT-CYB | -0.49 | -0.42 |
| AF347015.31 | -0.49 | -0.43 |
Section III. Gene Ontology annotation
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005739 | mitochondrion | IEA | - |