Gene Page: PLXNA3

Summary
GeneID  55558
Symbol  PLXNA3
Synonyms  6.3|HSSEXGENE|PLEXIN-A3|PLXN3|PLXN4|SEX|XAP-6
Description  plexin A3
See related  HGNC:9101|MIM:300022|Ensembl:ENSG00000130827|HPRD:02062|
Locus tag  XX-FW81657B9.3
Gene type  protein-coding
Map location  Xq28
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
GLB1L20.590.38
TMPRSS130.570.38
KIAA15300.560.45
PAPPA20.560.32
WNT7B0.550.32
CLCF10.550.49
CECR20.530.41
RP11-274B21.10.520.46
AC010522.10.520.45
DUOX10.520.42
Top 10 negatively co-expressed genes
DHRS7-0.43-0.47
C5orf35-0.37-0.48
PHYH-0.36-0.37
TMEM22-0.36-0.45
ACOT13-0.36-0.40
ITM2B-0.36-0.40
MGST2-0.35-0.40
PXMP3-0.35-0.46
ACYP2-0.35-0.37
HDDC2-0.35-0.38
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004888transmembrane receptor activityNAS8570614 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007411axon guidanceIEAaxon (GO term level: 13)-
GO:0021860pyramidal neuron developmentIEAneuron, Brain (GO term level: 12)-
GO:0048843negative regulation of axon extension involved in axon guidanceIEAaxon (GO term level: 16)-
GO:0007165signal transductionIEA-
GO:0007275multicellular organismal developmentTAS8570614 
GO:0050919negative chemotaxisIEA-
GO:0021766hippocampus developmentIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0016020membraneTAS8570614 
GO:0016021integral to membraneIEA-
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_CRMPS_IN_SEMA3A_SIGNALING 1414All SZGR genes in this pathway
REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION 1514All SZGR genes in this pathway
REACTOME_SEMAPHORIN_INTERACTIONS 6853All SZGR genes in this pathway
REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION 139All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_UP 380215All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP 450256All SZGR genes in this pathway
LOPEZ_MESOTELIOMA_SURVIVAL_TIME_UP 148All SZGR genes in this pathway
LOPEZ_MESOTHELIOMA_SURVIVAL_WORST_VS_BEST_UP 1410All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_TTD_UP 6439All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP 309199All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_UP 244151All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G1 6741All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
HELLER_HDAC_TARGETS_UP 317208All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
SYED_ESTRADIOL_RESPONSE 1915All SZGR genes in this pathway
LOPEZ_MESOTHELIOMA_SURVIVAL_OVERALL_DN 168All SZGR genes in this pathway
LOPEZ_MESOTHELIOMA_SURVIVAL_DN 126All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_UP 217131All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_GROUP1 13676All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
NABA_ECM_AFFILIATED 17189All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.1811817m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5068108171A,m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-1372262321Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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