Gene Page: MIOX
Summary ?
| GeneID | 55586 |
| Symbol | MIOX |
| Synonyms | ALDRL6 |
| Description | myo-inositol oxygenase |
| Reference | MIM:606774|HGNC:HGNC:14522|Ensembl:ENSG00000100253|HPRD:12443|Vega:OTTHUMG00000150207 |
| Gene type | protein-coding |
| Map location | 22q13.3 |
| Pascal p-value | 0.02 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| Expression | Meta-analysis of gene expression | P value: 1.648 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PIPOX | 0.74 | 0.79 |
| SUCLG2 | 0.74 | 0.73 |
| ADHFE1 | 0.73 | 0.78 |
| PBXIP1 | 0.73 | 0.79 |
| HADHB | 0.73 | 0.76 |
| MLC1 | 0.72 | 0.79 |
| ACOX2 | 0.71 | 0.75 |
| FAH | 0.71 | 0.78 |
| DECR1 | 0.71 | 0.73 |
| PHKG1 | 0.71 | 0.70 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| FAM131B | -0.60 | -0.65 |
| FAM49A | -0.59 | -0.65 |
| MYT1L | -0.59 | -0.65 |
| POLR3A | -0.59 | -0.63 |
| KIF3C | -0.59 | -0.63 |
| NMNAT2 | -0.58 | -0.63 |
| PAK7 | -0.58 | -0.66 |
| NOL4 | -0.58 | -0.64 |
| C6orf168 | -0.58 | -0.63 |
| MARK1 | -0.58 | -0.63 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004033 | aldo-keto reductase activity | ISS | - | |
| GO:0005506 | iron ion binding | IEA | - | |
| GO:0016651 | oxidoreductase activity, acting on NADH or NADPH | IEA | - | |
| GO:0050113 | inositol oxygenase activity | IEA | - | |
| GO:0046872 | metal ion binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0019310 | inositol catabolic process | ISS | - | |
| GO:0055114 | oxidation reduction | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005737 | cytoplasm | ISS | - | |
| GO:0016234 | inclusion body | ISS | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG ASCORBATE AND ALDARATE METABOLISM | 25 | 17 | All SZGR 2.0 genes in this pathway |
| KEGG INOSITOL PHOSPHATE METABOLISM | 54 | 42 | All SZGR 2.0 genes in this pathway |
| SHETH LIVER CANCER VS TXNIP LOSS PAM2 | 153 | 102 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF ICP WITH H3K27ME3 | 206 | 108 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN IPS ICP WITH H3K4ME3 AND H327ME3 | 126 | 83 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES ICP WITH H3K4ME3 | 718 | 401 | All SZGR 2.0 genes in this pathway |
| WANG NFKB TARGETS | 25 | 15 | All SZGR 2.0 genes in this pathway |