Gene Page: SLC30A6
Summary ?
| GeneID | 55676 |
| Symbol | SLC30A6 |
| Synonyms | MST103|MSTP103|ZNT6 |
| Description | solute carrier family 30 member 6 |
| Reference | MIM:611148|HGNC:HGNC:19305|Ensembl:ENSG00000152683|HPRD:15368|Vega:OTTHUMG00000128456 |
| Gene type | protein-coding |
| Map location | 2p22.3 |
| Pascal p-value | 0.433 |
| Fetal beta | 0.672 |
| DMG | 1 (# studies) |
| Support | ION BALANCE |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg22548000 | 2 | 32391035 | SLC30A6 | 3.42E-9 | -0.014 | 2.26E-6 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| TPI1 | 0.90 | 0.85 |
| ALKBH6 | 0.90 | 0.88 |
| RHBDL1 | 0.86 | 0.86 |
| MECR | 0.86 | 0.85 |
| ACOT8 | 0.86 | 0.84 |
| PGP | 0.85 | 0.86 |
| DHRS7B | 0.85 | 0.84 |
| FDX1L | 0.85 | 0.86 |
| SH3GLB2 | 0.84 | 0.81 |
| HAGH | 0.84 | 0.83 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| THOC2 | -0.57 | -0.60 |
| KIAA1949 | -0.56 | -0.54 |
| TUBB2B | -0.55 | -0.59 |
| SMURF2 | -0.54 | -0.53 |
| RBMX2 | -0.53 | -0.64 |
| SH3BP2 | -0.53 | -0.60 |
| ZNF551 | -0.53 | -0.45 |
| ZNF300 | -0.53 | -0.43 |
| TIGD1 | -0.53 | -0.48 |
| AC004017.1 | -0.53 | -0.46 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DODD NASOPHARYNGEAL CARCINOMA DN | 1375 | 806 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER UP | 181 | 108 | All SZGR 2.0 genes in this pathway |
| BROWN MYELOID CELL DEVELOPMENT UP | 165 | 100 | All SZGR 2.0 genes in this pathway |
| GRADE COLON AND RECTAL CANCER DN | 101 | 65 | All SZGR 2.0 genes in this pathway |
| ALONSO METASTASIS UP | 198 | 128 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA CHEMOTAXIS DN | 457 | 302 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA HAPTOTAXIS DN | 668 | 419 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE EARLY LATE | 317 | 190 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 AND SATB1 DN | 180 | 116 | All SZGR 2.0 genes in this pathway |