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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: DOK4

Summary

GeneID

55715

Symbol

DOK4

Synonyms

FLJ10488

Description

docking protein 4

Locus tag

Gene type

protein-coding

Map location

16q13

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

ZNF212

0.92

0.90

INTS9

0.92

0.91

RPIA

0.92

0.89

RBM15B

0.91

0.90

DAXX

0.91

0.90

RBM10

0.91

0.89

HDAC3

0.91

0.90

EHMT2

0.91

RAF1

0.91

SSRP1

0.91

Top 10 negatively co-expressed genes

AF347015.31

-0.77

-0.88

MT-CO2

-0.76

-0.88

AF347015.27

-0.76

-0.87

AF347015.33

-0.74

-0.85

AF347015.8

-0.74

-0.88

MT-CYB

-0.74

-0.86

AF347015.15

-0.72

-0.87

AIFM3

-0.72

-0.77

IFI27

-0.71

-0.82

FXYD1

-0.70

-0.82

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005066

transmembrane receptor protein tyrosine kinase signaling protein activity

IEA

GO:0005158

insulin receptor binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007399

nervous system development

IEA

neurite (GO term level: 5)

GO:0000165

MAPKKK cascade

IEA

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

IEA

Interactions

Shown by Network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CRK	CRKII	v-crk sarcoma virus CT10 oncogene homolog (avian)	-	HPRD	12730241
CRK	CRKII	v-crk sarcoma virus CT10 oncogene homolog (avian)	IRS5/DOK4 interacts with Crk. This interaction was modelled on a demonstrated interaction between human IRS5/DOK4 and hamster Crk.	BIND	12730241
FYN	MGC45350 \| SLK \| SYN	FYN oncogene related to SRC, FGR, YES	IRS5/DOK4 interacts with Fyn. This interaction was modelled on a demonstrated interaction between human IRS5/DOK4 and hamster Fyn.	BIND	12730241
FYN	MGC45350 \| SLK \| SYN	FYN oncogene related to SRC, FGR, YES	-	HPRD	12730241
RASA1	CM-AVM \| CMAVM \| DKFZp434N071 \| GAP \| PKWS \| RASA \| RASGAP \| p120GAP \| p120RASGAP	RAS p21 protein activator (GTPase activating protein) 1	-	HPRD	12730241
RASA1		RAS p21 protein activator (GTPase activating protein) 1	IRS5/DOK4 interacts with RasGAP. This interaction was modelled on a demonstrated interaction between human IRS5/DOK4 and hamster RasGAP.	BIND	12730241
RET	CDHF12 \| HSCR1 \| MEN2A \| MEN2B \| MTC1 \| PTC \| RET-ELE1 \| RET51	ret proto-oncogene	-	HPRD,BioGRID	11470823
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD	12730241
SRC	ASV \| SRC1 \| c-SRC \| p60-Src		IRS5/DOK4 interacts with Src. This interaction was modelled on a demonstrated interaction between human IRS5/DOK4 and hamster Src.	BIND	12730241

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-182	1389	1396	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-205	1362	1369	1A,m8	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
miR-214	962	968	m8	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
miR-214	962	968	m8	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
miR-216	1368	1374	1A	hsa-miR-216	UAAUCUCAGCUGGCAACUGUG
miR-33	969	976	1A,m8	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
miR-33	969	976	1A,m8	hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-491	940	947	1A,m8	hsa-miR-491^brain	AGUGGGGAACCCUUCCAUGAGGA
miR-544	1020	1026	m8	hsa-miR-544	AUUCUGCAUUUUUAGCAAGU
miR-96	1390	1396	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.