Gene Page: DHX32
Summary ?
| GeneID | 55760 |
| Symbol | DHX32 |
| Synonyms | DDX32|DHLP1 |
| Description | DEAH-box helicase 32 (putative) |
| Reference | MIM:607960|HGNC:HGNC:16717|Ensembl:ENSG00000089876|HPRD:06411|Vega:OTTHUMG00000019238 |
| Gene type | protein-coding |
| Map location | 10q26.2 |
| Pascal p-value | 0.013 |
| Sherlock p-value | 0.002 |
| Fetal beta | -0.22 |
| Support | Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.03487 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PPP1R1A | 0.62 | 0.51 |
| ALK | 0.61 | 0.61 |
| DMKN | 0.61 | 0.61 |
| NECAB2 | 0.60 | 0.76 |
| RSPO4 | 0.60 | 0.62 |
| MYH7 | 0.58 | 0.62 |
| SHD | 0.57 | 0.63 |
| IRF5 | 0.56 | 0.52 |
| FAM43B | 0.56 | 0.59 |
| RASSF7 | 0.56 | 0.50 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ZNF238 | -0.41 | -0.44 |
| DPP4 | -0.41 | -0.48 |
| NEUROD6 | -0.41 | -0.53 |
| MPPED1 | -0.41 | -0.45 |
| SLA | -0.40 | -0.38 |
| KLHL1 | -0.40 | -0.40 |
| ZEB2 | -0.40 | -0.43 |
| SNX7 | -0.39 | -0.41 |
| NEUROD2 | -0.39 | -0.46 |
| TMEM108 | -0.39 | -0.37 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | - | |
| GO:0005524 | ATP binding | IEA | - | |
| GO:0004386 | helicase activity | IEA | - | |
| GO:0016787 | hydrolase activity | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005634 | nucleus | IEA | - | |
| GO:0005739 | mitochondrion | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| ROVERSI GLIOMA COPY NUMBER DN | 54 | 37 | All SZGR 2.0 genes in this pathway |
| RAMPON ENRICHED LEARNING ENVIRONMENT LATE UP | 22 | 16 | All SZGR 2.0 genes in this pathway |
| ACEVEDO METHYLATED IN LIVER CANCER DN | 940 | 425 | All SZGR 2.0 genes in this pathway |
| COULOUARN TEMPORAL TGFB1 SIGNATURE UP | 109 | 68 | All SZGR 2.0 genes in this pathway |
| KOINUMA TARGETS OF SMAD2 OR SMAD3 | 824 | 528 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY STEM CELL DN | 428 | 246 | All SZGR 2.0 genes in this pathway |