Gene Page: GLT8D1

Summary ?
GeneID55830
SymbolGLT8D1
SynonymsAD-017|MSTP139
Descriptionglycosyltransferase 8 domain containing 1
ReferenceHGNC:HGNC:24870|Ensembl:ENSG00000016864|HPRD:12423|Vega:OTTHUMG00000158759
Gene typeprotein-coding
Map location3p21.1
Pascal p-value1.631E-7
Sherlock p-value1.106E-6
Fetal beta0.558
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWAScatGenome-wide Association StudiesThis data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
LK:YESGenome-wide Association StudyThis data set included 99 genes mapped to the 22 regions. The 24 leading SNPs were also included in CV:Ripke_2013
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs352169chr352236761GLT8D1558303.609E-5cis
rs352167chr352238655GLT8D1558300cis
rs352166chr352238676GLT8D1558301.477E-4cis
rs11712164chr352244050GLT8D1558304.831E-9cis
rs6445528chr352572446GLT8D1558301.745E-7cis
rs2878628chr352584714GLT8D1558305.91E-11cis
rs2251219chr352584786GLT8D1558301.291E-10cis
rs1961958chr352585989GLT8D1558306.363E-13cis
rs6778844chr352596397GLT8D1558302.932E-12cis
rs12487591chr352642935GLT8D1558302.187E-11cis
rs3755806chr352643684GLT8D1558304.695E-11cis
rs1561337chr352659962GLT8D1558302.187E-11cis
rs2289250chr352682945GLT8D1558302.336E-9cis
rs2289247chr352727256GLT8D1558302.716E-11cis
rs12635140chr352738164GLT8D1558309.134E-11cis
rs2072390chr352780508GLT8D1558302.534E-10cis
rs2336545chr352787602GLT8D1558303.301E-11cis
rs2240920chr352831008GLT8D1558303.317E-10cis
rs2256332chr352855864GLT8D1558300.01cis
rs2276817chr352860935GLT8D1558300.01cis
rs3733047chr352871928GLT8D1558306.838E-5cis
rs6803519chr352889770GLT8D1558306.741E-4cis
rs6795646chr352922620GLT8D1558300cis
rs2581815chr352982158GLT8D1558308.82E-4cis
rs2336669chr352994137GLT8D1558309.718E-4cis
rs4519686chr352997870GLT8D1558309.312E-4cis
rs9823697chr353002149GLT8D1558300.04cis
rs17304995chr353070754GLT8D1558306.679E-4cis
rs352169chr352236761GLT8D1558300trans
rs352167chr352238655GLT8D1558300.09trans
rs352166chr352238676GLT8D1558300.01trans
rs11712164chr352244050GLT8D1558301.185E-6trans
rs6445528chr352572446GLT8D1558303.783E-5trans
rs2878628chr352584714GLT8D1558301.531E-8trans
rs2251219chr352584786GLT8D1558303.298E-8trans
rs1961958chr352585989GLT8D1558301.596E-10trans
rs6778844chr352596397GLT8D1558307.25E-10trans
rs12487591chr352642935GLT8D1558305.729E-9trans
rs2289247chr352727256GLT8D1558307.145E-9trans
rs12635140chr352738164GLT8D1558302.356E-8trans
rs2072390chr352780508GLT8D1558306.25E-8trans
rs2336545chr352787602GLT8D1558308.707E-9trans
rs2240920chr352831008GLT8D1558308.149E-8trans
snp_a-22880260GLT8D1558300.02trans
rs3733047chr352871928GLT8D1558300.01trans
rs6803519chr352889770GLT8D1558300.05trans
rs6795646chr352922620GLT8D1558300.14trans
rs2581815chr352982158GLT8D1558300.06trans
rs2336669chr352994137GLT8D1558300.07trans
rs4519686chr352997870GLT8D1558300.07trans
rs17304995chr353070754GLT8D1558300.05trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TTBK10.920.94
AC115090.10.910.92
MGAT30.910.94
EPB41L10.900.92
ABR0.890.91
HTT0.890.91
AL117209.10.880.92
KIF1A0.880.90
PHLPP20.870.90
C11orf410.870.90
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.59-0.62
GNG11-0.59-0.65
C1orf54-0.59-0.70
AF347015.31-0.56-0.57
AL139819.3-0.56-0.62
MT-CO2-0.54-0.56
HIGD1B-0.54-0.56
SYCP3-0.54-0.64
PLA2G5-0.54-0.54
DBI-0.53-0.62

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
ZHOU INFLAMMATORY RESPONSE LIVE DN 384220All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA DN 284156All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459276All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800473All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH VS LOW UP 66All SZGR 2.0 genes in this pathway
CEBALLOS TARGETS OF TP53 AND MYC DN 3831All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED MODERATELY VS POORLY UP 12171All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI DN 172107All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371218All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298200All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN 318220All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN 373196All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
ROSS LEUKEMIA WITH MLL FUSIONS 7849All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351238All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253192All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841431All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB 14583All SZGR 2.0 genes in this pathway
THILLAINADESAN ZNF217 TARGETS UP 4422All SZGR 2.0 genes in this pathway