Gene Page: PRPS1

Summary
GeneID  5631
Symbol  PRPS1
Synonyms  ARTS|CMTX5|KIAA0967|PPRibP|PRSI
Description  phosphoribosyl pyrophosphate synthetase 1
See related  HGNC:9462|MIM:311850|Ensembl:ENSG00000147224|HPRD:02413|
Locus tag  RP11-540N4.1
Gene type  protein-coding
Map location  Xq21.32-q24
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
FAM108B10.910.91
KIAA01960.860.87
PTK20.860.87
SCARB20.860.90
FOXN20.860.89
TMEM87A0.860.86
NBR10.860.87
DIP2B0.850.89
ZDHHC90.850.87
FMNL20.840.85
Top 10 negatively co-expressed genes
AF347015.21-0.62-0.61
IL32-0.59-0.58
MT-CO2-0.57-0.58
CXCL14-0.57-0.61
PLA2G5-0.56-0.62
IFI27-0.56-0.58
C1orf54-0.55-0.58
AF347015.31-0.55-0.57
HIGD1B-0.55-0.56
FXYD1-0.55-0.58
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000287magnesium ion bindingIEA-
GO:0005524ATP bindingIDA16939420 
GO:0004749ribose phosphate diphosphokinase activityEXP4328836 
GO:0004749ribose phosphate diphosphokinase activityIDA16939420 |17701900 
GO:0004749ribose phosphate diphosphokinase activityIEA-
GO:0016740transferase activityIEA-
GO:0016301kinase activityIEA-
GO:0042803protein homodimerization activityIPI16939420 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentTASneurite (GO term level: 5)8253776 
GO:0009116nucleoside metabolic processIEA-
GO:0006144purine base metabolic processTAS8253776 
GO:0009156ribonucleoside monophosphate biosynthetic processIEA-
GO:0009165nucleotide biosynthetic processIEA-
GO:0007605sensory perception of soundIEA-
GO:0044249cellular biosynthetic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP4328836 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GORASP2DKFZp434D156 | FLJ13139 | GOLPH6 | GRASP55 | GRS2 | p59golgi reassembly stacking protein 2, 55kDaTwo-hybridBioGRID16189514 
PRPS1ARTS | CMTX5 | KIAA0967 | PPRibP | PRSIphosphoribosyl pyrophosphate synthetase 1Two-hybridBioGRID16189514 
PRPSAP1PAP39phosphoribosyl pyrophosphate synthetase-associated protein 1-HPRD,BioGRID9366267 
SPG21ACP33 | BM-019 | GL010 | MASPARDIN | MASTspastic paraplegia 21 (autosomal recessive, Mast syndrome)Two-hybridBioGRID16189514 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124/506848854m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-233323381Ahsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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