Gene Page: BAD

Summary
GeneID  572
Symbol  BAD
Synonyms  BBC2|BCL2L8
Description  BCL2-associated agonist of cell death
See related  HGNC:936|MIM:603167|Ensembl:ENSG00000002330|HPRD:04409|
Locus tag  -
Gene type  protein-coding
Map location  11q13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.144 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CASKIN10.710.72
C19orf260.680.66
COL20A10.680.74
C15orf590.680.66
HHIPL10.680.70
ZBTB470.670.68
BEGAIN0.660.62
KIFC20.650.61
BZRAP10.650.65
AL355987.10.640.64
Top 10 negatively co-expressed genes
ALG5-0.48-0.49
C8orf59-0.47-0.47
RPS7-0.46-0.47
TPT1-0.46-0.49
RPS27L-0.46-0.44
FUNDC2-0.45-0.45
FAM96A-0.44-0.46
PPP2R3C-0.44-0.46
RPL24-0.43-0.48
CNIH4-0.42-0.41
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI9973195 |10949025 
GO:0005515protein bindingNAS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006007glucose catabolic processIEA-
GO:0008633activation of pro-apoptotic gene productsEXP15231831 
GO:0008624induction of apoptosis by extracellular signalsIEA-
GO:0042593glucose homeostasisIEA-
GO:0019221cytokine-mediated signaling pathwayIEA-
GO:0043281regulation of caspase activityIEA-
GO:0045579positive regulation of B cell differentiationIEA-
GO:0045582positive regulation of T cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP9381178 |10195903 |12657644 
|15183529 
GO:0005737cytoplasmNAS-
GO:0005739mitochondrionIEA-
GO:0005741mitochondrial outer membraneEXP10195903 
GO:0005741mitochondrial outer membraneNAS-
GO:0016020membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKT1AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHAv-akt murine thymoma viral oncogene homolog 1Reconstituted ComplexBioGRID11500364 
BCL2Bcl-2B-cell CLL/lymphoma 2Bcl-2 interacts with Bad.BIND9130713 
-HPRD,BioGRID7834748 
Bad interacts with Bcl-2.BIND15694340 
Bad interacts with Bcl-2.BIND15574335 
BCL2A1ACC-1 | ACC-2 | BCL2L5 | BFL1 | GRS | HBPA1BCL2-related protein A1Bad interacts with A1. This interaction was modelled on a demonstrated interaction between human Bad and mouse A1.BIND15694340 
-HPRD10381646 |11483855 
Protein-peptide
Reconstituted Complex
Two-hybrid		BioGRID11483855 |15694340 
BCL2L1BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xSBCL2-like 1-HPRD7834748 |9305851 
|9388232 |11483855 
|11494146 |11583631 
Bcl-XL interacts with Bad. This interaction was modelled on a demonstrated interaction between Bcl-XL from an unspecified species and human Bad.BIND15721256 
Affinity Capture-Western
Protein-peptide
Reconstituted Complex
Two-hybrid		BioGRID7834748 |9824152 
|10620799 |11206074 
|11494146 |12115603 
|12137781 |15694340 
|15705582 
Bad interacts with Bcl-XL.BIND15694340 
-HPRD7834748 |11494146|11206074 
Bad interacts with Bcl-xL.BIND15574335 
BCL2L10BCL-B | Boo | Diva | MGC129810 | MGC129811BCL2-like 10 (apoptosis facilitator)-HPRD11278245 
BCL2L2BCL-W | BCLW | KIAA0271BCL2-like 2-HPRD,BioGRID11483855 |12115603 
Bad interacts with Bcl-w.BIND15694340 
EWSR1EWSEwing sarcoma breakpoint region 1Two-hybridBioGRID16189514 
MCL1BCL2L3 | EAT | MCL1L | MCL1S | MGC104264 | MGC1839 | TMmyeloid cell leukemia sequence 1 (BCL2-related)-HPRD10579309 |10837489 
Protein-peptide
Reconstituted Complex
Two-hybrid		BioGRID11483855 |15694340 
PIM2-pim-2 oncogene-HPRD,BioGRID12954615 
PPP1CAMGC15877 | MGC1674 | PP-1A | PPP1Aprotein phosphatase 1, catalytic subunit, alpha isoform-HPRD10811615 
PRKACAMGC102831 | MGC48865 | PKACAprotein kinase, cAMP-dependent, catalytic, alphaReconstituted ComplexBioGRID11500364 
PRKCIDXS1179E | MGC26534 | PKCI | nPKC-iotaprotein kinase C, iotaReconstituted ComplexBioGRID15705582 
RPS6KA1HU-1 | MAPKAPK1A | RSK | RSK1ribosomal protein S6 kinase, 90kDa, polypeptide 1Reconstituted ComplexBioGRID11500364 
RPS6KA5MGC1911 | MSK1 | MSPK1 | RLPKribosomal protein S6 kinase, 90kDa, polypeptide 5Reconstituted ComplexBioGRID11500364 
S100A1042C | ANX2L | ANX2LG | CAL1L | CLP11 | Ca[1] | GP11 | MGC111133 | P11 | p10S100 calcium binding protein A10-HPRD,BioGRID9369453 
SFNYWHASstratifinTwo-hybridBioGRID16189514 
SNCAMGC110988 | NACP | PARK1 | PARK4 | PD1synuclein, alpha (non A4 component of amyloid precursor)Reconstituted ComplexBioGRID11742726 
-HPRD10407019 
YWHABGW128 | HS1 | KCIP-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide-HPRD,BioGRID9369453 
YWHAE14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDStyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide-HPRD,BioGRID9369453 
YWHAHYWHA1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide-HPRD,BioGRID9369453 
YWHAQ14-3-3 | 1C5 | HS1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide-HPRD,BioGRID9369453 
YWHAZKCIP-1 | MGC111427 | MGC126532 | MGC138156tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide-HPRD,BioGRID11410287 
 


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