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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: PTPN2

Summary

GeneID

5771

Symbol

PTPN2

Synonyms

PTPT|TC-PTP|TCELLPTP|TCPTP

Description

protein tyrosine phosphatase, non-receptor type 2

Locus tag

Gene type

protein-coding

Map location

18p11.3-p11.2

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Expression

P value: 2.032

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

DOCK7

0.88

0.92

C1orf9

0.87

0.88

SMURF2

0.87

0.92

AC092436.3

0.87

0.86

BMPR1A

0.86

0.87

GNA13

0.86

0.88

F2R

0.86

QSER1

0.85

0.90

BTBD7

0.85

0.87

ARID2

0.85

0.87

Top 10 negatively co-expressed genes

C5orf53

-0.60

-0.69

CA4

-0.59

-0.69

HLA-F

-0.58

-0.63

MT-CO2

-0.57

-0.73

ASPHD1

-0.56

-0.57

AF347015.27

-0.56

-0.70

FBXO2

-0.56

-0.58

IFI27

-0.55

-0.72

MUSTN1

-0.55

-0.66

AF347015.31

-0.55

-0.70

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004872

receptor activity

IEA

GO:0005515

protein binding

IPI

12907755 |16293614

GO:0004725

protein tyrosine phosphatase activity

IEA

GO:0004725

protein tyrosine phosphatase activity

TAS

2546150

GO:0016787

hydrolase activity

IEA

GO:0016791

phosphatase activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006470

protein amino acid dephosphorylation

IEA

GO:0006470

protein amino acid dephosphorylation

TAS

2546150

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005737

cytoplasm

IEA

Interactions

Shown by Network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ITGA1	CD49a \| VLA1	integrin, alpha 1	Integrin-alpha-1 interacts with TCPTP.	BIND	15592458
SFN	YWHAS	stratifin	Affinity Capture-MS	BioGRID	15778465
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	PTPN2 (TCPTP) interacts with Src. This interaction was modelled on a demonstrated interaction between human PTPN2 and chicken Src.	BIND	15696169
STAT3	APRF \| FLJ20882 \| HIES \| MGC16063	signal transducer and activator of transcription 3 (acute-phase response factor)	-	HPRD,BioGRID	12359225
TRAF2	MGC:45012 \| TRAP \| TRAP3	TNF receptor-associated factor 2	PTPN2 (TCPTP) interacts with TRAF2.	BIND	15696169

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-130/301	27	33	1A	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-137	365	372	1A,m8	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-205	765	771	1A	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.