Gene Page

Gene Page: PTPN4

Summary

GeneID

5775

Symbol

PTPN4

Synonyms

PTPMEG|PTPMEG1

Description

protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)

Locus tag

Gene type

protein-coding

Map location

2q14.2

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.023

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.00755

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004726

non-membrane spanning protein tyrosine phosphatase activity

TAS

1648233

GO:0016787

hydrolase activity

IEA

GO:0005198

structural molecule activity

IEA

GO:0008092

cytoskeletal protein binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006470

protein amino acid dephosphorylation

TAS

1648233

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005856

cytoskeleton

IEA

GO:0005737

cytoplasm

TAS

1648233

GO:0005886

plasma membrane

IEA

GO:0019898

extrinsic to membrane

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ATRX	ATR2 \| MGC2094 \| MRXHF1 \| RAD54 \| RAD54L \| SFM1 \| SHS \| XH2 \| XNP \| ZNF-HX	alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)	Two-hybrid	BioGRID	16169070
EEF1A1	CCS-3 \| CCS3 \| EEF-1 \| EEF1A \| EF-Tu \| EF1A \| FLJ25721 \| GRAF-1EF \| HNGC:16303 \| LENG7 \| MGC102687 \| MGC131894 \| MGC16224 \| PTI1 \| eEF1A-1	eukaryotic translation elongation factor 1 alpha 1	Two-hybrid	BioGRID	16169070
EEF1G	EF1G \| GIG35	eukaryotic translation elongation factor 1 gamma	Two-hybrid	BioGRID	16169070
GRID2	MGC117022 \| MGC117023 \| MGC117024	glutamate receptor, ionotropic, delta 2	-	HPRD,BioGRID	10748123
GRIN2A	NMDAR2A \| NR2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	-	HPRD,BioGRID	10748123
KAT5	ESA1 \| HTATIP \| HTATIP1 \| PLIP \| TIP \| TIP60 \| cPLA2	K(lysine) acetyltransferase 5	Two-hybrid	BioGRID	16169070
LPL	HDLCQ11 \| LIPD	lipoprotein lipase	Two-hybrid	BioGRID	16169070
ZZEF1	FLJ10821 \| FLJ23789 \| FLJ45574 \| KIAA0399 \| MGC166929 \| ZZZ4	zinc finger, ZZ-type with EF-hand domain 1	Two-hybrid	BioGRID	16169070

Pathway annotation

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-128	52	58	m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	52	58	m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-142-5p	143	149	m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-143	329	335	m8	hsa-miR-143^brain	UGAGAUGAAGCACUGUAGCUCA
miR-17-5p/20/93.mr/106/519.d	141	148	1A,m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-183	56	63	1A,m8	hsa-miR-183	UAUGGCACUGGUAGAAUUCACUG
miR-330	208	214	m8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.