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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: PXN

Summary

GeneID

5829

Symbol

PXN

Synonyms

FLJ16691

Description

paxillin

Locus tag

hCG_1778014

Gene type

protein-coding

Map location

12q24.31

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0679

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

RAB11A

0.91

FBXO3

0.91

0.89

KIFAP3

0.91

CUL2

0.91

0.89

MED4

0.90

YWHAZ

0.90

0.89

RAB2A

0.90

0.88

PNMA1

0.90

0.89

DYNC1LI1

0.90

0.89

GLOD4

0.90

0.89

Top 10 negatively co-expressed genes

MT-CO2

-0.78

-0.76

FXYD1

-0.78

-0.77

AF347015.33

-0.77

-0.74

AF347015.31

-0.75

MT-CYB

-0.75

-0.74

AF347015.8

-0.74

-0.73

AF347015.2

-0.73

-0.74

AF347015.21

-0.72

-0.70

HIGD1B

-0.72

AF347015.27

-0.72

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005515

protein binding

IPI

14688263

GO:0008270

zinc ion binding

IEA

GO:0017166

vinculin binding

IPI

9054445

GO:0046872

metal ion binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007172

signal complex assembly

TAS

9054445

GO:0007160

cell-matrix adhesion

IEA

GO:0007155

cell adhesion

NAS

10840040

GO:0007165

signal transduction

TAS

7534286

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005856

cytoskeleton

IEA

GO:0005875

microtubule associated complex

TAS

10840040

GO:0005737

cytoplasm

IEA

GO:0005886

plasma membrane

EXP

15574420

GO:0030054

cell junction

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	-	HPRD	9603926
ARHGAP5	GFI2 \| RhoGAP5 \| p190-B	Rho GTPase activating protein 5	Affinity Capture-Western	BioGRID	10092539
ASAP1	AMAP1 \| CENTB4 \| DDEF1 \| KIAA1249 \| PAG2 \| PAP \| ZG14P	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	in vitro	BioGRID	12149250
ASAP2	AMAP2 \| CENTB3 \| DDEF2 \| FLJ42910 \| KIAA0400 \| PAG3 \| PAP \| Pap-alpha \| SHAG1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	in vitro Reconstituted Complex	BioGRID	10749932 \|12149250
ASAP2		ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	-	HPRD	10749932\|12149250
BCAR1	CAS \| CAS1 \| CASS1 \| CRKAS \| P130Cas	breast cancer anti-estrogen resistance 1	Affinity Capture-Western	BioGRID	8810278 \|11577104
BCR	ALL \| BCR-ABL1 \| BCR1 \| CML \| D22S11 \| D22S662 \| FLJ16453 \| PHL	breakpoint cluster region	Affinity Capture-Western Co-purification	BioGRID	7534286 \|8641358
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	Co-purification	BioGRID	8641358
CEACAM1	BGP \| BGP1 \| BGPI	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	-	HPRD,BioGRID	11035932
CRK	CRKII	v-crk sarcoma virus CT10 oncogene homolog (avian)	-	HPRD,BioGRID	12198159
CRKL	-	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	-	HPRD,BioGRID	7493940
CSK	MGC117393	c-src tyrosine kinase	-	HPRD,BioGRID	7529872
CTTN	EMS1 \| FLJ34459	cortactin	PXN (Paxillin) interacts with an unspecified isoform of CTTN (cortactin).	BIND	15719014
FYN	MGC45350 \| SLK \| SYN	FYN oncogene related to SRC, FGR, YES	-	HPRD,BioGRID	10804218
GIT1	-	G protein-coupled receptor kinase interacting ArfGAP 1	GIT1 interacts with Paxillin (PXN).	BIND	15793570
			Affinity Capture-Western	BioGRID	12629171
			-	HPRD	10896954 \|12153727 \|14523024
GIT2	CAT-2 \| DKFZp686G01261 \| KIAA0148 \| MGC760	G protein-coupled receptor kinase interacting ArfGAP 2	-	HPRD,BioGRID	11251077
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	Reconstituted Complex	BioGRID	10085298
GSN	DKFZp313L0718	gelsolin (amyloidosis, Finnish type)	-	HPRD,BioGRID	11577104
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	Affinity Capture-Western	BioGRID	10082579
ILK	DKFZp686F1765 \| P59	integrin-linked kinase	-	HPRD,BioGRID	11304546 \|11694518
ITGA4	CD49D \| IA4 \| MGC90518	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	-	HPRD,BioGRID	11533025 \|11919182
ITGA4	CD49D \| IA4 \| MGC90518		Paxillin (PXN) interacts with integrin alpha-4 (ITGA4).	BIND	10604475
ITGA6	CD49f \| DKFZp686J01244 \| FLJ18737 \| ITGA6B \| VLA-6	integrin, alpha 6	-	HPRD,BioGRID	12033289
ITGA9	ALPHA-RLC \| ITGA4L \| RLC	integrin, alpha 9	-	HPRD,BioGRID	11598204
ITGB1	CD29 \| FNRB \| GPIIA \| MDF2 \| MSK12 \| VLA-BETA \| VLAB	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	-	HPRD,BioGRID	7657702\|10804218
ITGB3	CD61 \| GP3A \| GPIIIa	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	Reconstituted Complex	BioGRID	11683411
LCK	YT16 \| p56lck \| pp58lck	lymphocyte-specific protein tyrosine kinase	-	HPRD,BioGRID	9488700
LIMK1	LIMK	LIM domain kinase 1	-	HPRD	15023529
MATK	CHK \| CTK \| DKFZp434N1212 \| HHYLTK \| HYL \| HYLTK \| Lsk \| MGC1708 \| MGC2101	megakaryocyte-associated tyrosine kinase	-	HPRD,BioGRID	10080957
NCK1	MGC12668 \| NCK \| NCKalpha	NCK adaptor protein 1	-	HPRD,BioGRID	10330411
NEDD9	CAS-L \| CAS2 \| CASL \| CASS2 \| HEF1 \| dJ49G10.2 \| dJ761I2.1	neural precursor cell expressed, developmentally down-regulated 9	-	HPRD,BioGRID	10455189
NF2	ACN \| BANF \| SCH	neurofibromin 2 (merlin)	-	HPRD,BioGRID	12118253
PABPC1	PAB1 \| PABP \| PABP1 \| PABPC2 \| PABPL1	poly(A) binding protein, cytoplasmic 1	-	HPRD,BioGRID	11704675
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	-	HPRD	10330411
PAK3	CDKN1A \| MRX30 \| MRX47 \| OPHN3 \| PAK3beta \| bPAK \| hPAK3	p21 protein (Cdc42/Rac)-activated kinase 3	-	HPRD	11096073
PARVA	FLJ10793 \| FLJ12254 \| MXRA2	parvin, alpha	-	HPRD	11134073
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	Co-purification	BioGRID	8641358
PKD1	PBP	polycystic kidney disease 1 (autosomal dominant)	-	HPRD	11113628
PKLR	PK1 \| PKL \| PKR \| PKRL \| RPK	pyruvate kinase, liver and RBC	Affinity Capture-Western	BioGRID	12006652
PPP2CA	PP2Ac \| PP2CA \| RP-C	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Affinity Capture-Western	BioGRID	10675325
PTEN	10q23del \| BZS \| MGC11227 \| MHAM \| MMAC1 \| PTEN1 \| TEP1	phosphatase and tensin homolog	-	HPRD,BioGRID	11857088
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	FAK interacts with paxillin.	BIND	11113628
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	-	HPRD,BioGRID	8922390
PTK2B	CADTK \| CAKB \| FADK2 \| FAK2 \| FRNK \| PKB \| PTK \| PYK2 \| RAFTK	PTK2B protein tyrosine kinase 2 beta	-	HPRD,BioGRID	9099734
PTPN11	BPTP3 \| CFC \| MGC14433 \| NS1 \| PTP-1D \| PTP2C \| SH-PTP2 \| SH-PTP3 \| SHP2	protein tyrosine phosphatase, non-receptor type 11	-	HPRD	8986614 \|10082579 \|10655584
PTPN12	PTP-PEST \| PTPG1	protein tyrosine phosphatase, non-receptor type 12	-	HPRD	10085298 \|10400685 \|10625692 \|11950600
PTPN12	PTP-PEST \| PTPG1	protein tyrosine phosphatase, non-receptor type 12	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	9497381 \|10400685 \|10625692
PTPRH	FLJ39938 \| MGC133058 \| MGC133059 \| SAP-1	protein tyrosine phosphatase, receptor type, H	-	HPRD,BioGRID	11278335
RAB8B	FLJ38125	RAB8B, member RAS oncogene family	Affinity Capture-Western	BioGRID	12639940
RASA1	CM-AVM \| CMAVM \| DKFZp434N071 \| GAP \| PKWS \| RASA \| RASGAP \| p120GAP \| p120RASGAP	RAS p21 protein activator (GTPase activating protein) 1	-	HPRD,BioGRID	10092539
REPS2	POB1	RALBP1 associated Eps domain containing 2	-	HPRD,BioGRID	12149250
SELE	CD62E \| ELAM \| ELAM1 \| ESEL \| LECAM2	selectin E	-	HPRD,BioGRID	8609175
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Reconstituted Complex	BioGRID	10085298
SRC	ASV \| SRC1 \| c-SRC \| p60-Src		-	HPRD	7534286
SYK	DKFZp313N1010 \| FLJ25043 \| FLJ37489	spleen tyrosine kinase	-	HPRD,BioGRID	9590268
TGFB1I1	ARA55 \| HIC-5 \| HIC5 \| TSC-5	transforming growth factor beta 1 induced transcript 1	Affinity Capture-Western	BioGRID	11463817
TLN1	ILWEQ \| KIAA1027 \| TLN	talin 1	-	HPRD,BioGRID	7534286
TRIP6	MGC10556 \| MGC10558 \| MGC29959 \| MGC3837 \| MGC4423 \| OIP1 \| ZRP-1	thyroid hormone receptor interactor 6	-	HPRD,BioGRID	14688263
TUBA1B	K-ALPHA-1	tubulin, alpha 1b	-	HPRD	10840040
TUBA3C	TUBA2 \| bA408E5.3	tubulin, alpha 3c	-	HPRD	10840040
TUBG1	TUBG \| TUBGCP1	tubulin, gamma 1	-	HPRD,BioGRID	10840040 \|11950600
TUBG2	MGC131994	tubulin, gamma 2	-	HPRD	10840040
VCL	CMD1W \| MVCL	vinculin	-	HPRD,BioGRID	9054445
VCL	CMD1W \| MVCL	vinculin	-	HPRD	7525621 \|7534286\|9054445

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-132/212	984	990	m8	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	984	990	m8	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-137	639	645	1A	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-145	102	109	1A,m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-199	314	321	1A,m8	hsa-miR-199a	CCCAGUGUUCAGACUACCUGUUC
miR-199	314	321	1A,m8	hsa-miR-199b	CCCAGUGUUUAGACUAUCUGUUC
miR-218	920	926	1A	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-326	1454	1460	m8	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.