Gene Page

Gene Page: SNX6

Summary

GeneID

58533

Symbol

SNX6

Synonyms

MGC3157|MSTP010|TFAF2

Description

sorting nexin 6

Locus tag

Gene type

protein-coding

Map location

14q13.2

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.2955

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005515

protein binding

IEA

GO:0005515

protein binding

IPI

11279102

GO:0042803

protein homodimerization activity

IPI

11279102

GO:0035091

phosphoinositide binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007175

negative regulation of epidermal growth factor receptor activity

NAS

11279102

GO:0007154

cell communication

IEA

GO:0006886

intracellular protein transport

NAS

11279102

GO:0016481

negative regulation of transcription

IDA

11279102

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

IDA

11279102

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005622

intracellular

NAS

11279102

GO:0005737

cytoplasm

IDA

11279102

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACVR2B	ACTRIIB \| ActR-IIB \| MGC116908	activin A receptor, type IIB	-	HPRD,BioGRID	11279102
ACVRL1	ACVRLK1 \| ALK-1 \| ALK1 \| HHT \| HHT2 \| ORW2 \| SKR3 \| TSR-I	activin A receptor type II-like 1	-	HPRD,BioGRID	11279102
BMPR1B	ALK-6 \| ALK6 \| CDw293	bone morphogenetic protein receptor, type IB	-	HPRD,BioGRID	11279102
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	-	HPRD,BioGRID	11279102
INSR	CD220 \| HHF5	insulin receptor	-	HPRD,BioGRID	11279102
LEPR	CD295 \| OBR	leptin receptor	-	HPRD,BioGRID	11279102
PDGFRA	CD140A \| MGC74795 \| PDGFR2 \| Rhe-PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	-	HPRD,BioGRID	11279102
PIM1	PIM	pim-1 oncogene	-	HPRD	11591366
PIM1	PIM	pim-1 oncogene	-	HPRD,BioGRID	11279102
SMAD1	BSP1 \| JV4-1 \| JV41 \| MADH1 \| MADR1	SMAD family member 1	-	HPRD	11279102
SNX1	HsT17379 \| MGC8664 \| SNX1A \| Vps5	sorting nexin 1	Affinity Capture-Western in vitro in vivo	BioGRID	11279102
SNX2	MGC5204 \| TRG-9	sorting nexin 2	-	HPRD,BioGRID	11279102
SNX4	-	sorting nexin 4	-	HPRD,BioGRID	11279102
TGFBR1	AAT5 \| ACVRLK4 \| ALK-5 \| ALK5 \| LDS1A \| LDS2A \| SKR4 \| TGFR-1	transforming growth factor, beta receptor 1	-	HPRD,BioGRID	11279102
TGFBR2	AAT3 \| FAA3 \| LDS1B \| LDS2B \| MFS2 \| RIIC \| TAAD2 \| TGFR-2 \| TGFbeta-RII	transforming growth factor, beta receptor II (70/80kDa)	-	HPRD,BioGRID	11279102

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	583	590	1A,m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	583	589	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	583	589	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-142-5p	537	543	1A	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-299-5p	601	607	1A	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-30-5p	1288	1295	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.