Gene Page: RIT2

Summary ?
GeneID6014
SymbolRIT2
SynonymsRIBA|RIN|ROC2
DescriptionRas-like without CAAX 2
ReferenceMIM:609592|HGNC:HGNC:10017|Ensembl:ENSG00000152214|HPRD:15253|Vega:OTTHUMG00000132611
Gene typeprotein-coding
Map location18q12.3
Pascal p-value0.212
Sherlock p-value0.542
Fetal beta-1.173
eGeneAnterior cingulate cortex BA24

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs4380121839929420RIT2ENSG00000152214.83.477E-60766237gtex_brain_ba24
rs3713571839937973RIT2ENSG00000152214.82.756E-60757684gtex_brain_ba24
rs1731991839948111RIT2ENSG00000152214.82.756E-60747546gtex_brain_ba24
rs11565421839953034RIT2ENSG00000152214.82.756E-60742623gtex_brain_ba24
rs14426481839954248RIT2ENSG00000152214.82.756E-60741409gtex_brain_ba24
rs72384851839955648RIT2ENSG00000152214.88.572E-70740009gtex_brain_ba24
rs782720311839956300RIT2ENSG00000152214.82.563E-60739357gtex_brain_ba24
rs18222641839957067RIT2ENSG00000152214.88.572E-70738590gtex_brain_ba24
rs13727621839962759RIT2ENSG00000152214.82.756E-60732898gtex_brain_ba24
rs13727631839962875RIT2ENSG00000152214.82.756E-60732782gtex_brain_ba24
rs287603991839964365RIT2ENSG00000152214.82.756E-60731292gtex_brain_ba24
rs21657141839965570RIT2ENSG00000152214.83.616E-70730087gtex_brain_ba24
rs65074761839968491RIT2ENSG00000152214.82.756E-60727166gtex_brain_ba24
rs93042711839969314RIT2ENSG00000152214.83.616E-70726343gtex_brain_ba24
rs3980794141839969448RIT2ENSG00000152214.81.281E-60726209gtex_brain_ba24
rs93042721839970428RIT2ENSG00000152214.82.756E-60725229gtex_brain_ba24
rs610544611839970791RIT2ENSG00000152214.84.513E-70724866gtex_brain_ba24
rs72339241839970828RIT2ENSG00000152214.88.542E-80724829gtex_brain_ba24
rs3462711839972779RIT2ENSG00000152214.82.756E-60722878gtex_brain_ba24
rs1445885251839973904RIT2ENSG00000152214.83.616E-70721753gtex_brain_ba24
rs770130351839973905RIT2ENSG00000152214.81.304E-60721752gtex_brain_ba24
rs1808321839974236RIT2ENSG00000152214.82.756E-60721421gtex_brain_ba24
rs1893901839974593RIT2ENSG00000152214.88.572E-70721064gtex_brain_ba24
rs3462421839976421RIT2ENSG00000152214.82.142E-60719236gtex_brain_ba24
rs61462821839977236RIT2ENSG00000152214.83.392E-70718421gtex_brain_ba24
rs3462441839977576RIT2ENSG00000152214.82.756E-60718081gtex_brain_ba24
rs3462451839977967RIT2ENSG00000152214.88.572E-70717690gtex_brain_ba24
rs3462461839978690RIT2ENSG00000152214.82.756E-60716967gtex_brain_ba24
rs4456171839979396RIT2ENSG00000152214.88.572E-70716261gtex_brain_ba24
rs3462471839981520RIT2ENSG00000152214.82.756E-60714137gtex_brain_ba24
rs3462481839981791RIT2ENSG00000152214.82.756E-60713866gtex_brain_ba24
rs3462491839982232RIT2ENSG00000152214.83.616E-70713425gtex_brain_ba24
rs3462511839985171RIT2ENSG00000152214.82.756E-60710486gtex_brain_ba24
rs3462521839986589RIT2ENSG00000152214.82.756E-60709068gtex_brain_ba24
rs3462531839986664RIT2ENSG00000152214.82.756E-60708993gtex_brain_ba24
rs3462541839986724RIT2ENSG00000152214.82.756E-60708933gtex_brain_ba24
rs3462551839987217RIT2ENSG00000152214.82.756E-60708440gtex_brain_ba24
rs3462561839987515RIT2ENSG00000152214.82.756E-60708142gtex_brain_ba24
rs3462571839987876RIT2ENSG00000152214.82.756E-60707781gtex_brain_ba24
rs3462581839988049RIT2ENSG00000152214.82.756E-60707608gtex_brain_ba24
rs3462591839988232RIT2ENSG00000152214.82.756E-60707425gtex_brain_ba24
rs3462601839988367RIT2ENSG00000152214.82.756E-60707290gtex_brain_ba24
rs3462611839988884RIT2ENSG00000152214.82.88E-60706773gtex_brain_ba24
rs711740991839988962RIT2ENSG00000152214.82.797E-60706695gtex_brain_ba24
rs3462631839989221RIT2ENSG00000152214.82.756E-60706436gtex_brain_ba24
rs3462641839989228RIT2ENSG00000152214.82.756E-60706429gtex_brain_ba24
rs3462651839989431RIT2ENSG00000152214.82.756E-60706226gtex_brain_ba24
rs1893891839990442RIT2ENSG00000152214.82.756E-60705215gtex_brain_ba24
rs4453641839991820RIT2ENSG00000152214.82.756E-60703837gtex_brain_ba24
rs3462661839992444RIT2ENSG00000152214.82.756E-60703213gtex_brain_ba24
rs3462671839992969RIT2ENSG00000152214.82.756E-60702688gtex_brain_ba24
rs3462681839993094RIT2ENSG00000152214.82.756E-60702563gtex_brain_ba24
rs3462691839993389RIT2ENSG00000152214.83.616E-70702268gtex_brain_ba24
rs4516421839993631RIT2ENSG00000152214.82.701E-60702026gtex_brain_ba24
rs3462701839993663RIT2ENSG00000152214.82.756E-60701994gtex_brain_ba24
rs1808301839993924RIT2ENSG00000152214.82.756E-60701733gtex_brain_ba24
rs1808311839994772RIT2ENSG00000152214.82.756E-60700885gtex_brain_ba24
rs1731961839995744RIT2ENSG00000152214.83.616E-70699913gtex_brain_ba24
rs25847981839996101RIT2ENSG00000152214.82.756E-60699556gtex_brain_ba24
rs6751371839996712RIT2ENSG00000152214.82.756E-60698945gtex_brain_ba24
rs4179131839997582RIT2ENSG00000152214.81.281E-60698075gtex_brain_ba24
rs4105551839997911RIT2ENSG00000152214.82.361E-60697746gtex_brain_ba24
rs4378231839998037RIT2ENSG00000152214.81.281E-60697620gtex_brain_ba24
rs3978140491839998578RIT2ENSG00000152214.81.241E-60697079gtex_brain_ba24
rs25677341839999207RIT2ENSG00000152214.82.756E-60696450gtex_brain_ba24
rs3461791840000484RIT2ENSG00000152214.82.756E-60695173gtex_brain_ba24
rs1731951840000500RIT2ENSG00000152214.82.756E-60695157gtex_brain_ba24
rs3461781840000852RIT2ENSG00000152214.83.665E-70694805gtex_brain_ba24
rs25677301840003693RIT2ENSG00000152214.82.756E-60691964gtex_brain_ba24
rs25677291840003812RIT2ENSG00000152214.82.756E-60691845gtex_brain_ba24
rs3461811840008452RIT2ENSG00000152214.82.756E-60687205gtex_brain_ba24
rs3461801840008628RIT2ENSG00000152214.81.281E-60687029gtex_brain_ba24
rs3461991840009943RIT2ENSG00000152214.82.756E-60685714gtex_brain_ba24
rs3462001840011018RIT2ENSG00000152214.81.281E-60684639gtex_brain_ba24
rs3462011840011957RIT2ENSG00000152214.82.756E-60683700gtex_brain_ba24
rs3462021840012078RIT2ENSG00000152214.81.281E-60683579gtex_brain_ba24
rs3462041840013669RIT2ENSG00000152214.81.281E-60681988gtex_brain_ba24
rs3462061840013858RIT2ENSG00000152214.81.281E-60681799gtex_brain_ba24
rs3462081840014493RIT2ENSG00000152214.82.756E-60681164gtex_brain_ba24
rs1711191840014887RIT2ENSG00000152214.82.756E-60680770gtex_brain_ba24
rs1849251840015179RIT2ENSG00000152214.82.756E-60680478gtex_brain_ba24
rs3462091840016600RIT2ENSG00000152214.82.756E-60679057gtex_brain_ba24
rs3462121840017917RIT2ENSG00000152214.88.572E-70677740gtex_brain_ba24
rs3462131840018447RIT2ENSG00000152214.88.572E-70677210gtex_brain_ba24
rs3462141840018754RIT2ENSG00000152214.82.733E-60676903gtex_brain_ba24
rs3462181840022060RIT2ENSG00000152214.81.038E-60673597gtex_brain_ba24
rs3462221840024675RIT2ENSG00000152214.82.756E-60670982gtex_brain_ba24
rs3462231840024947RIT2ENSG00000152214.88.572E-70670710gtex_brain_ba24
rs58244281840026912RIT2ENSG00000152214.83.6E-60668745gtex_brain_ba24
rs3462241840028311RIT2ENSG00000152214.82.756E-60667346gtex_brain_ba24
rs3462251840028359RIT2ENSG00000152214.82.756E-60667298gtex_brain_ba24
rs575526261840030718RIT2ENSG00000152214.82.756E-60664939gtex_brain_ba24
rs14318341840030890RIT2ENSG00000152214.82.756E-60664767gtex_brain_ba24
rs3461821840031333RIT2ENSG00000152214.82.756E-60664324gtex_brain_ba24
rs3461831840031488RIT2ENSG00000152214.82.756E-60664169gtex_brain_ba24
rs2379701840031936RIT2ENSG00000152214.82.756E-60663721gtex_brain_ba24
rs3461841840032691RIT2ENSG00000152214.82.756E-60662966gtex_brain_ba24
rs1683001840032866RIT2ENSG00000152214.82.756E-60662791gtex_brain_ba24
rs3461851840033310RIT2ENSG00000152214.82.756E-60662347gtex_brain_ba24
rs3461861840033369RIT2ENSG00000152214.82.756E-60662288gtex_brain_ba24
rs3461871840034530RIT2ENSG00000152214.82.756E-60661127gtex_brain_ba24
rs3461881840035147RIT2ENSG00000152214.82.756E-60660510gtex_brain_ba24
rs3461891840035275RIT2ENSG00000152214.82.756E-60660382gtex_brain_ba24
rs3461901840035793RIT2ENSG00000152214.82.756E-60659864gtex_brain_ba24
rs3461911840035917RIT2ENSG00000152214.82.756E-60659740gtex_brain_ba24
rs3461921840036138RIT2ENSG00000152214.82.796E-60659519gtex_brain_ba24
rs3756149661840036171RIT2ENSG00000152214.82.774E-60659486gtex_brain_ba24
rs9712931840036223RIT2ENSG00000152214.82.828E-60659434gtex_brain_ba24
rs4000641840036313RIT2ENSG00000152214.82.931E-60659344gtex_brain_ba24
rs3461931840037280RIT2ENSG00000152214.82.151E-60658377gtex_brain_ba24
rs3461941840037616RIT2ENSG00000152214.85.213E-90658041gtex_brain_ba24
rs728935691840092256RIT2ENSG00000152214.83.347E-60603401gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RNASEN0.920.92
WDR50.920.93
SFRS140.920.93
PRCC0.920.92
TACC20.920.94
UBAP2L0.910.92
LSM14B0.910.93
MSL10.910.92
SETD50.910.93
TOPBP10.910.92
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.86-0.89
MT-CO2-0.85-0.88
AF347015.33-0.82-0.85
AF347015.27-0.82-0.86
MT-CYB-0.82-0.85
AF347015.8-0.81-0.87
HIGD1B-0.80-0.86
AF347015.21-0.79-0.89
AF347015.2-0.79-0.86
FXYD1-0.79-0.84

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003924GTPase activityNAS8824319 
GO:0005516calmodulin bindingTAS8824319 
GO:0005525GTP bindingTAS8824319 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)8918462 
GO:0007165signal transductionTAS8918462 
GO:0007264small GTPase mediated signal transductionEXP10712923 
GO:0007264small GTPase mediated signal transductionNAS8824319 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005886plasma membraneTAS8824319 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID TRKR PATHWAY 6248All SZGR 2.0 genes in this pathway
PID MAPK TRK PATHWAY 3431All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217167All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137105All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO ERKS 3630All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO P38 VIA RIT AND RIN 1514All SZGR 2.0 genes in this pathway
SILIGAN BOUND BY EWS FLT1 FUSION 4734All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 24HR DN 3321All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL SHORT TERM 3215All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA RADIATION 8159All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP 226164All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K9ME3 UP 14175All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422277All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548370All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/2062502571A,m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC