Gene Page: RLBP1
Summary ?
| GeneID | 6017 |
| Symbol | RLBP1 |
| Synonyms | CRALBP |
| Description | retinaldehyde binding protein 1 |
| Reference | MIM:180090|HGNC:HGNC:10024|Ensembl:ENSG00000140522|HPRD:01572|Vega:OTTHUMG00000172884 |
| Gene type | protein-coding |
| Map location | 15q26 |
| Pascal p-value | 0.002 |
| Sherlock p-value | 0.905 |
| eGene | Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs950540 | chr15 | 89754863 | RLBP1 | 6017 | 0.11 | cis | ||
| rs950541 | chr15 | 89754953 | RLBP1 | 6017 | 0.15 | cis | ||
| rs17228503 | chr15 | 89763205 | RLBP1 | 6017 | 0.01 | cis | ||
| rs10451012 | chr15 | 89769904 | RLBP1 | 6017 | 0.02 | cis | ||
| rs17228716 | chr15 | 89773504 | RLBP1 | 6017 | 0.19 | cis | ||
| rs2679774 | chr8 | 98390991 | RLBP1 | 6017 | 0.2 | trans | ||
| rs7193497 | chr16 | 89064018 | RLBP1 | 6017 | 0.14 | trans | ||
| rs17003861 | chrX | 101204311 | RLBP1 | 6017 | 0.09 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ANKRD42 | 0.90 | 0.89 |
| GCC2 | 0.89 | 0.89 |
| PDE8B | 0.89 | 0.84 |
| MFSD6 | 0.89 | 0.85 |
| CLIP4 | 0.89 | 0.87 |
| DDHD2 | 0.89 | 0.87 |
| NSF | 0.88 | 0.86 |
| NCOA7 | 0.88 | 0.87 |
| TAF4B | 0.88 | 0.86 |
| GPRASP1 | 0.88 | 0.87 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| BCL7C | -0.50 | -0.56 |
| RPL35 | -0.47 | -0.51 |
| RPL36 | -0.46 | -0.50 |
| RPLP1 | -0.45 | -0.48 |
| AC006276.2 | -0.44 | -0.41 |
| TBC1D10A | -0.43 | -0.34 |
| RPL27 | -0.43 | -0.43 |
| RPL18 | -0.42 | -0.49 |
| FAU | -0.42 | -0.41 |
| RPL31 | -0.42 | -0.42 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005488 | binding | TAS | 9326942 | |
| GO:0005502 | 11-cis retinal binding | IEA | - | |
| GO:0005215 | transporter activity | IEA | - | |
| GO:0019841 | retinol binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007601 | visual perception | TAS | 9326942 | |
| GO:0006810 | transport | IEA | - | |
| GO:0006776 | vitamin A metabolic process | TAS | 9326942 | |
| GO:0050896 | response to stimulus | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005622 | intracellular | IEA | - | |
| GO:0005625 | soluble fraction | TAS | 9326942 | |
| GO:0005737 | cytoplasm | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY E2F4 UNSTIMULATED | 728 | 415 | All SZGR 2.0 genes in this pathway |
| ZHENG GLIOBLASTOMA PLASTICITY UP | 250 | 168 | All SZGR 2.0 genes in this pathway |
| BEIER GLIOMA STEM CELL UP | 39 | 17 | All SZGR 2.0 genes in this pathway |