Gene Page: BCL3

Summary
GeneID  602
Symbol  BCL3
Synonyms  BCL4|D19S37
Description  B-cell CLL/lymphoma 3
See related  HGNC:998|MIM:109560|Ensembl:ENSG00000069399|HPRD:00179|
Locus tag  -
Gene type  protein-coding
Map location  19q13.1-q13.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
KDM2B0.960.98
MYCN0.960.94
TBC1D140.950.95
BRD30.950.95
TMEM570.950.96
GMEB10.950.95
KDM4A0.950.95
AP006289.10.950.95
NCK20.940.95
SRGAP20.940.96
Top 10 negatively co-expressed genes
AIFM3-0.73-0.82
HLA-F-0.73-0.80
TSC22D4-0.72-0.83
C5orf53-0.72-0.77
HEPN1-0.71-0.79
AF347015.31-0.71-0.93
SERPINB6-0.71-0.76
HSD17B14-0.71-0.83
ALDOC-0.71-0.75
S100B-0.71-0.87
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008134transcription factor bindingIPI8196632 |11387332 |16108830 
|16306601 
GO:0030674protein binding, bridgingTAS16306601 
GO:0030528transcription regulator activityIDA16306601 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002268follicular dendritic cell differentiationIEAdendrite (GO term level: 5)-
GO:0000060protein import into nucleus, translocationIMP16280327 
GO:0002315marginal zone B cell differentiationIEA-
GO:0002455humoral immune response mediated by circulating immunoglobulinIEA-
GO:0002467germinal center formationIEA-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0010225response to UV-CIDA16384933 
GO:0009615response to virusIDA16306601 
GO:0006974response to DNA damage stimulusIDA16384933 
GO:0007249I-kappaB kinase/NF-kappaB cascadeIDA8196632 
GO:0019730antimicrobial humoral responseIEA-
GO:0043066negative regulation of apoptosisIDA16384933 
GO:0042345regulation of NF-kappaB import into nucleusIEP8196632 
GO:0016481negative regulation of transcriptionIDA16306601 
GO:0051101regulation of DNA bindingIEP9407099 
GO:0042771DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosisIMP16384933 
GO:0042742defense response to bacteriumIEA-
GO:0042832defense response to protozoanIEA-
GO:0032729positive regulation of interferon-gamma productionIEA-
GO:0042088T-helper 1 type immune responseIEA-
GO:0042536negative regulation of tumor necrosis factor biosynthetic processIEA-
GO:0030198extracellular matrix organizationIEA-
GO:0045941positive regulation of transcriptionIDA16384933 
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
GO:0045727positive regulation of translationIMP16384933 
GO:0045082positive regulation of interleukin-10 biosynthetic processIEA-
GO:0045064T-helper 2 cell differentiationIEA-
GO:0048536spleen developmentIEA-
GO:0045415negative regulation of interleukin-8 biosynthetic processIMP16306601 
GO:0051457maintenance of protein location in nucleusNAS8196632 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA8196632 |16280327 |16306601 
GO:0005737cytoplasmIDA11387332 
GO:0033257Bcl3/NF-kappaB2 complexIDA9407099 
GO:0032996Bcl3-Bcl10 complexIDA16280327 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BARD1-BRCA1 associated RING domain 1-HPRD,BioGRID10362352 
CD824F9 | C33 | GR15 | IA4 | KAI1 | R2 | SAR2 | ST6 | TSPAN27CD82 moleculeBCL3 interacts with the CD82 (KAI1) promoter.BIND15829968 
COPS5CSN5 | JAB1 | MGC3149 | MOV-34 | SGN5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)-HPRD,BioGRID10362352 
CREBBPCBP | KAT3A | RSTSCREB binding protein-HPRD10497212 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDaCTNNB1 (beta-catenin) interacts with BCL3.BIND15829968 
EP300KAT3B | p300E1A binding protein p300Reconstituted Complex
Two-hybrid		BioGRID10497212 
FOSAP-1 | C-FOSv-fos FBJ murine osteosarcoma viral oncogene homolog-HPRD,BioGRID10497212 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD,BioGRID9576921 
GSK3ADKFZp686D0638glycogen synthase kinase 3 alphaGSK3-alpha interacts with BCL-3.BIND15469820 
GSK3B-glycogen synthase kinase 3 betaGSK3-beta interacts with and phosphorylates BCL-3.BIND15469820 
GTF2A1MGC129969 | MGC129970 | TF2A1 | TFIIAgeneral transcription factor IIA, 1, 19/37kDa-HPRD,BioGRID9812988 
GTF2BTF2B | TFIIBgeneral transcription factor IIBReconstituted ComplexBioGRID9812988 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1HDAC1 interacts with BCL-3.BIND15469820 
HDAC3HD3 | RPD3 | RPD3-2histone deacetylase 3HDAC3 interacts with BCL-3.BIND15469820 
HDAC6FLJ16239 | HD6 | JM21histone deacetylase 6HDAC6 interacts with BCL-3. This interaction was modelled on a demonstrated interaction between HDAC6 from an unspecified species and human BCL-3.BIND15469820 
JUNAP-1 | AP1 | c-Junjun oncogene-HPRD,BioGRID10497212 
KAT5ESA1 | HTATIP | HTATIP1 | PLIP | TIP | TIP60 | cPLA2K(lysine) acetyltransferase 5-HPRD,BioGRID10362352 
HTATIP (Tip60) interacts with BCL3.BIND15829968 
MAPK3ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3mitogen-activated protein kinase 3Erk1 interacts with and phosphorylates BCL-3.BIND15469820 
N4BP2B3BP | FLJ10680 | KIAA1413NEDD4 binding protein 2-HPRD,BioGRID12730195 
NCOA1F-SRC-1 | KAT13A | MGC129719 | MGC129720 | NCoA-1 | RIP160 | SRC-1 | SRC1 | bHLHe42nuclear receptor coactivator 1-HPRD,BioGRID10497212 
NCOA6AIB3 | ANTP | ASC2 | HOX1.1 | HOXA7 | KIAA0181 | NRC | PRIP | RAP250 | TRBPnuclear receptor coactivator 6Reconstituted ComplexBioGRID10497212 
NFKB1DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105nuclear factor of kappa light polypeptide gene enhancer in B-cells 1p50 interacts with BCL-3. This interaction was modelled on a demonstrated interaction between p50 from an unspecified species and human BCL-3.BIND15469820 
-HPRD10362352 
Affinity Capture-Western
Co-localization
Co-purification
Reconstituted Complex		BioGRID8428580 |10469655 
|14678988 
NFKB1 (p50) interacts with BCL3.BIND15829968 
NFKB2LYT-10 | LYT10nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)p52 interacts with BCL-3. This interaction was modelled on a demonstrated interaction between p52 from an unspecified species and human BCL-3.BIND15469820 
-HPRD8453667 |11707390 
Co-localization
Reconstituted Complex		BioGRID8453667 |14678988 
PIR-pirin (iron-binding nuclear protein)Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID10362352 
RAB9ARAB9RAB9A, member RAS oncogene family-HPRD11485202 |11707390 
RELBI-REL | IRELv-rel reticuloendotheliosis viral oncogene homolog BCo-localizationBioGRID14678988 
RUVBL2CGI-46 | ECP51 | INO80J | REPTIN | RVB2 | TIH2 | TIP48 | TIP49BRuvB-like 2 (E. coli)RUVBL2 (reptin) interacts with BCL3.BIND15829968 
RXRAFLJ00280 | FLJ00318 | FLJ16020 | FLJ16733 | MGC102720 | NR2B1retinoid X receptor, alpha-HPRD,BioGRID9812988 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD11707390 
TBPGTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIIDTATA box binding protein-HPRD,BioGRID9812988 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-12873791Ahsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-191211281A,m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-2773801A,m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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