SZGR2

Summary ?

GeneID	60482
Symbol	SLC5A7
Synonyms	CHT\|CHT1\|HMN7A
Description	solute carrier family 5 member 7
Reference	MIM:608761\|HGNC:HGNC:14025\|Ensembl:ENSG00000115665\|HPRD:12294\|Vega:OTTHUMG00000130959
Gene type	protein-coding
Map location	2q12
Pascal p-value	0.156
DMG	1 (# studies)
eGene	Myers' cis & trans Meta
Support	CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
DNM:Fromer_2014	Whole Exome Sequencing analysis	This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I	Genome scan meta-analysis	Psr: 0.0004
GSMA_IIA	Genome scan meta-analysis (All samples)	Psr: 0.00755
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 4

Section I. Genetics and epigenetics annotation

DNM table

Gene	Chromosome	Position	Ref	Alt	Transcript	AA change	Mutation type	Sift	CG46	Trait	Study
SLC5A7	chr2	108626717	G	A	NM_021815	p.381M>I	missense			Schizophrenia	DNM:Fromer_2014

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg03983336	2	108602542	SLC5A7	3.572E-4	-0.472	0.042	DMG:Wockner_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs260675	chr2	109600118	SLC5A7	60482	8.89E-6	cis
rs734994	chr1	30796504	SLC5A7	60482	0.05	trans
rs17108402	chr1	53846252	SLC5A7	60482	0.12	trans
rs17091285	chr1	71957915	SLC5A7	60482	0.01	trans
rs11162132	chr1	76833107	SLC5A7	60482	0.06	trans
rs6688662	chr1	76842132	SLC5A7	60482	0	trans
rs11163032	chr1	80954584	SLC5A7	60482	0.11	trans
rs7539781	chr1	90856245	SLC5A7	60482	0.16	trans
rs421660	chr1	91633187	SLC5A7	60482	0.16	trans
rs12096089	chr1	112349065	SLC5A7	60482	0.08	trans
rs1891733	chr1	164807829	SLC5A7	60482	0	trans
rs12118136	chr1	164812580	SLC5A7	60482	0	trans
rs17392895	chr1	164814782	SLC5A7	60482	0	trans
rs512189	chr1	182632586	SLC5A7	60482	3.055E-4	trans
rs16823145	chr1	184397914	SLC5A7	60482	0.14	trans
rs2096444	chr1	187436241	SLC5A7	60482	0.18	trans
rs16849110	chr1	201567374	SLC5A7	60482	0	trans
rs7516762	chr1	202092579	SLC5A7	60482	0.16	trans
rs17163777	chr1	223468731	SLC5A7	60482	0.15	trans
rs6666913	chr1	237092144	SLC5A7	60482	8.445E-10	trans
rs16865199	chr2	6621910	SLC5A7	60482	0.01	trans
rs16865228	chr2	6629622	SLC5A7	60482	0.01	trans
rs16865230	chr2	6630187	SLC5A7	60482	0.01	trans
rs11691188	chr2	6631799	SLC5A7	60482	0.01	trans
rs10209546	chr2	53408320	SLC5A7	60482	7.336E-6	trans
rs3755119	chr2	53957339	SLC5A7	60482	0.01	trans
rs2303604	chr2	71828422	SLC5A7	60482	0.16	trans
rs13401483	chr2	84219167	SLC5A7	60482	0.05	trans
rs260675	chr2	109600118	SLC5A7	60482	0	trans
rs7596511	chr2	120010898	SLC5A7	60482	0.01	trans
rs7574824	chr2	130696073	SLC5A7	60482	0.02	trans
rs13403353	chr2	144067716	SLC5A7	60482	0.03	trans
rs10176716	chr2	151596595	SLC5A7	60482	0.02	trans
rs10195263	chr2	151725791	SLC5A7	60482	0.11	trans
rs12694629	chr2	157312146	SLC5A7	60482	0.01	trans
rs10515928	chr2	160074898	SLC5A7	60482	0	trans
rs9287785	chr2	160075008	SLC5A7	60482	0	trans
rs10490004	chr2	160076139	SLC5A7	60482	0	trans
rs11903200	chr2	160076308	SLC5A7	60482	0	trans
rs2241023	chr2	160081335	SLC5A7	60482	0	trans
rs10490003	chr2	160082889	SLC5A7	60482	0	trans
rs3815475	chr2	160114314	SLC5A7	60482	0.02	trans
rs10189317	chr2	160123106	SLC5A7	60482	0	trans
rs8179587	chr2	160187588	SLC5A7	60482	0.01	trans
rs3755433	chr2	160269002	SLC5A7	60482	0.04	trans
rs7589313	chr2	174771910	SLC5A7	60482	0.08	trans
rs11884423	chr2	189086098	SLC5A7	60482	0.15	trans
rs4453654	chr2	189185130	SLC5A7	60482	0.03	trans
rs7587596	chr2	189361401	SLC5A7	60482	0.09	trans
rs13413644	chr2	189475948	SLC5A7	60482	0.02	trans
rs13397537	chr2	189737534	SLC5A7	60482	0.18	trans
rs10510296	chr3	4697202	SLC5A7	60482	0.19	trans
rs17049214	chr3	8545477	SLC5A7	60482	0.09	trans
rs9855575	chr3	15514062	SLC5A7	60482	0.07	trans
rs17015415	chr3	24933888	SLC5A7	60482	0.02	trans
rs17038645	chr3	39304569	SLC5A7	60482	0.14	trans
rs7646474	chr3	46011068	SLC5A7	60482	0.01	trans
rs2109558	chr3	52501615	SLC5A7	60482	0.07	trans
rs11923953	chr3	64365756	SLC5A7	60482	0	trans
rs17342237	chr3	65072365	SLC5A7	60482	0.06	trans
snp_a-1952572		0	SLC5A7	60482	0.14	trans
rs6548978	chr3	68139529	SLC5A7	60482	0	trans
rs17011179	chr3	73501887	SLC5A7	60482	0.03	trans
rs6784863	chr3	73525073	SLC5A7	60482	0.15	trans
rs9880961	chr3	74573769	SLC5A7	60482	0.16	trans
rs7609917	chr3	76094301	SLC5A7	60482	5.502E-10	trans
rs2324466	chr3	76100753	SLC5A7	60482	1.914E-16	trans
rs17013713	chr3	76105150	SLC5A7	60482	2.987E-16	trans
rs17013722	chr3	76107656	SLC5A7	60482	1.914E-16	trans
rs17013724	chr3	76107684	SLC5A7	60482	1.914E-16	trans
rs13326424		0	SLC5A7	60482	0.09	trans
rs11127757	chr3	82043061	SLC5A7	60482	0.04	trans
rs1919561	chr3	82067572	SLC5A7	60482	0.08	trans
rs9876340	chr3	82074984	SLC5A7	60482	0.14	trans
rs7619146	chr3	82098527	SLC5A7	60482	0.03	trans
rs7622355	chr3	82107080	SLC5A7	60482	0.16	trans
rs2178316	chr3	82187874	SLC5A7	60482	0.05	trans
rs2705554	chr3	112273545	SLC5A7	60482	0.09	trans
rs7644174	chr3	112722325	SLC5A7	60482	0.08	trans
rs4312656	chr3	115157721	SLC5A7	60482	0.03	trans
rs16859029	chr3	146759514	SLC5A7	60482	0.07	trans
rs16854658	chr3	169674405	SLC5A7	60482	0.15	trans
rs16854694	chr3	169701831	SLC5A7	60482	0.05	trans
rs179852	chr3	172328734	SLC5A7	60482	0.09	trans
rs16831155	chr3	173574763	SLC5A7	60482	0	trans
rs9882442	chr3	173644484	SLC5A7	60482	0.04	trans
rs13351019		0	SLC5A7	60482	0.11	trans
rs10015205	chr4	26144278	SLC5A7	60482	0.11	trans
rs16991886	chr4	36048970	SLC5A7	60482	0	trans
rs12646252		0	SLC5A7	60482	0.03	trans
rs1389042	chr4	82973241	SLC5A7	60482	0.03	trans
rs11734196	chr4	102796071	SLC5A7	60482	0	trans
rs10212684	chr4	102822506	SLC5A7	60482	4.351E-4	trans
rs7656183	chr4	114600890	SLC5A7	60482	0.03	trans
rs17007390	chr4	124705927	SLC5A7	60482	0.01	trans
rs681601	chr4	137983010	SLC5A7	60482	0.13	trans
rs6858531	chr4	141053847	SLC5A7	60482	0.08	trans
rs11937178	chr4	148847598	SLC5A7	60482	0	trans
rs11934409	chr4	148848884	SLC5A7	60482	0	trans
rs17044232	chr4	164770343	SLC5A7	60482	0.08	trans
rs2605050	chr4	180362144	SLC5A7	60482	0	trans
rs4301163	chr4	187861271	SLC5A7	60482	0.01	trans
rs9986296	chr5	3199318	SLC5A7	60482	5.674E-6	trans
rs16876290	chr5	5790694	SLC5A7	60482	0.11	trans
rs2455248	chr5	36478729	SLC5A7	60482	0.11	trans
rs6897533	chr5	72660099	SLC5A7	60482	0.04	trans
rs12658469	chr5	72670113	SLC5A7	60482	0.03	trans
rs2007137	chr5	73094609	SLC5A7	60482	0.19	trans
rs10072756	chr5	112995774	SLC5A7	60482	0.19	trans
rs17502163	chr5	120026331	SLC5A7	60482	0.1	trans
rs17149372	chr5	121907416	SLC5A7	60482	0.19	trans
rs920385	chr5	124490714	SLC5A7	60482	0.01	trans
rs2895773	chr5	148114635	SLC5A7	60482	0	trans
rs10059267	chr5	168676624	SLC5A7	60482	0.02	trans
rs10078402	chr5	168678851	SLC5A7	60482	0.02	trans
rs17077791	chr5	176616523	SLC5A7	60482	0.07	trans
rs2281351	chr6	187343	SLC5A7	60482	0.01	trans
rs9396617	chr6	15924214	SLC5A7	60482	0.02	trans
rs199055	chr6	23490116	SLC5A7	60482	0.2	trans
rs726836	chr6	25843925	SLC5A7	60482	0.01	trans
rs7740062	chr6	27705597	SLC5A7	60482	0.01	trans
rs200470	chr6	27762186	SLC5A7	60482	0	trans
rs201005	chr6	27804159	SLC5A7	60482	0	trans
rs200955	chr6	27839311	SLC5A7	60482	0.01	trans
rs200959	chr6	27842046	SLC5A7	60482	0.01	trans
rs839777	chr6	27909656	SLC5A7	60482	0.01	trans
rs149898	chr6	27958071	SLC5A7	60482	0.01	trans
rs156741	chr6	27962383	SLC5A7	60482	0.09	trans
rs156742	chr6	27963191	SLC5A7	60482	0.01	trans
rs175955	chr6	28059733	SLC5A7	60482	0.01	trans
rs1225593	chr6	28150518	SLC5A7	60482	0.01	trans
rs16894180	chr6	28628465	SLC5A7	60482	0.18	trans
rs195749	chr6	37253745	SLC5A7	60482	1.134E-4	trans
rs4435942	chr6	37694937	SLC5A7	60482	0.03	trans
rs16896683	chr6	43687846	SLC5A7	60482	8.012E-4	trans
rs16884946	chr6	54056193	SLC5A7	60482	0.12	trans
rs6936385	chr6	85228895	SLC5A7	60482	0.18	trans
rs16875134	chr6	85489519	SLC5A7	60482	0	trans
rs16875178	chr6	85516099	SLC5A7	60482	0.01	trans
rs7762250	chr6	144475063	SLC5A7	60482	0.05	trans
rs11961018	chr6	145288413	SLC5A7	60482	0.12	trans
rs9497157	chr6	145288521	SLC5A7	60482	0.05	trans
rs3735131	chr7	2962292	SLC5A7	60482	0.19	trans
rs7808764	chr7	10297264	SLC5A7	60482	0.17	trans
rs1005524	chr7	20596813	SLC5A7	60482	0.01	trans
rs17145334	chr7	21808409	SLC5A7	60482	0	trans
rs17148638	chr7	24065071	SLC5A7	60482	0.08	trans
rs895578	chr7	35410694	SLC5A7	60482	0.02	trans
rs2013491	chr7	91946015	SLC5A7	60482	0.04	trans
rs992435	chr7	97050802	SLC5A7	60482	9.471E-4	trans
rs7810149	chr7	111899363	SLC5A7	60482	0.15	trans
rs17159863	chr7	112311225	SLC5A7	60482	0.07	trans
rs10488380	chr7	131922414	SLC5A7	60482	0.17	trans
rs12532261	chr7	132264028	SLC5A7	60482	0.03	trans
rs12533690	chr7	132265977	SLC5A7	60482	0.01	trans
rs952827	chr7	150176106	SLC5A7	60482	0.1	trans
rs7810706	chr7	150831288	SLC5A7	60482	0.13	trans
rs8190856	chr8	18079123	SLC5A7	60482	0.06	trans
rs1017329	chr8	40281396	SLC5A7	60482	0.02	trans
rs16920368	chr8	55392852	SLC5A7	60482	1.679E-5	trans
rs997574	chr8	61098557	SLC5A7	60482	0.2	trans
rs10086973	chr8	61105602	SLC5A7	60482	0.04	trans
rs16927318	chr8	62365911	SLC5A7	60482	2.398E-6	trans
rs348150	chr8	73371619	SLC5A7	60482	3.728E-4	trans
rs16938220	chr8	73377940	SLC5A7	60482	4.224E-4	trans
rs7843769	chr8	83608406	SLC5A7	60482	0	trans
rs7830923	chr8	83608478	SLC5A7	60482	0	trans
rs16910790	chr8	83621808	SLC5A7	60482	0	trans
rs16910793	chr8	83621841	SLC5A7	60482	0	trans
rs16910802	chr8	83622265	SLC5A7	60482	0	trans
rs16910804	chr8	83622540	SLC5A7	60482	0	trans
rs1969215	chr8	108644706	SLC5A7	60482	0.02	trans
rs1448721	chr8	136924784	SLC5A7	60482	0.12	trans
rs16908622	chr8	139231604	SLC5A7	60482	0.01	trans
rs4545144	chr8	139689307	SLC5A7	60482	9.126E-4	trans
rs10815658	chr9	7709422	SLC5A7	60482	0	trans
rs16910463	chr9	26444298	SLC5A7	60482	0.15	trans
rs1410387	chr9	89359203	SLC5A7	60482	0.19	trans
rs180038	chr9	101514415	SLC5A7	60482	0	trans
rs4742740	chr9	101524552	SLC5A7	60482	0	trans
rs4743277	chr9	101557528	SLC5A7	60482	0	trans
rs10119434	chr9	110944789	SLC5A7	60482	3.665E-4	trans
rs10983187	chr9	119238934	SLC5A7	60482	0.01	trans
rs11251091	chr10	2249852	SLC5A7	60482	0.01	trans
rs17274849	chr10	2738293	SLC5A7	60482	0.03	trans
rs11007809	chr10	30209705	SLC5A7	60482	0.05	trans
rs11190152	chr10	101325914	SLC5A7	60482	0.17	trans
rs11193467	chr10	109217296	SLC5A7	60482	0.03	trans
rs11193944	chr10	109948063	SLC5A7	60482	0.16	trans
rs7920992	chr10	130402940	SLC5A7	60482	0.02	trans
rs17233214	chr11	21367388	SLC5A7	60482	0.03	trans
rs16911034	chr11	23302320	SLC5A7	60482	0	trans
rs10734372	chr11	26090747	SLC5A7	60482	0.15	trans
rs17309677	chr11	27139906	SLC5A7	60482	0.16	trans
rs3802783	chr11	27150261	SLC5A7	60482	0.14	trans
rs17309691	chr11	27183494	SLC5A7	60482	0.15	trans
rs12224887	chr11	37400374	SLC5A7	60482	0.03	trans
rs1002405	chr11	85572958	SLC5A7	60482	0	trans
rs17148600	chr11	85628826	SLC5A7	60482	0.08	trans
rs11219646	chr11	124279239	SLC5A7	60482	0.16	trans
rs956959	chr11	124400687	SLC5A7	60482	0.01	trans
rs11569358	chr12	6553503	SLC5A7	60482	0.07	trans
rs7311343	chr12	21228780	SLC5A7	60482	0.01	trans
rs11177887	chr12	41093631	SLC5A7	60482	0.02	trans
rs12305552	chr12	41797385	SLC5A7	60482	0.18	trans
rs2069410	chr12	56364644	SLC5A7	60482	8.49E-14	trans
rs17120736	chr12	58785277	SLC5A7	60482	0.09	trans
rs11115597	chr12	83509142	SLC5A7	60482	6.26E-4	trans
rs10746278	chr12	83789575	SLC5A7	60482	0	trans
rs7979024	chr12	84506011	SLC5A7	60482	0.02	trans
rs11105124	chr12	89375908	SLC5A7	60482	0	trans
rs17837122	chr12	92660211	SLC5A7	60482	0.01	trans
rs7972610	chr12	93486183	SLC5A7	60482	0.17	trans
rs17021407	chr12	94013807	SLC5A7	60482	0.01	trans
rs17031683	chr12	102005385	SLC5A7	60482	0.09	trans
rs825045	chr12	102045030	SLC5A7	60482	0.04	trans
rs6539020	chr12	102308189	SLC5A7	60482	0.03	trans
rs4770243	chr13	22662276	SLC5A7	60482	0.02	trans
rs1885898	chr13	22676828	SLC5A7	60482	0.11	trans
rs1885900	chr13	22676939	SLC5A7	60482	0.11	trans
rs1125957	chr13	22693170	SLC5A7	60482	0.11	trans
rs17078563	chr13	23864835	SLC5A7	60482	0.02	trans
rs9670212	chr13	29070572	SLC5A7	60482	0	trans
rs17834315	chr13	37991091	SLC5A7	60482	2.928E-9	trans
rs17055627	chr13	38019666	SLC5A7	60482	0.06	trans
rs17072833	chr13	49914392	SLC5A7	60482	0.01	trans
rs575555	chr13	52437620	SLC5A7	60482	0.01	trans
rs11841288	chr13	60215833	SLC5A7	60482	0	trans
rs987035	chr13	106274330	SLC5A7	60482	0.01	trans
rs16967008	chr13	106287437	SLC5A7	60482	0.02	trans
rs16975617	chr13	110867407	SLC5A7	60482	0	trans
rs17110779	chr14	26599617	SLC5A7	60482	0.11	trans
rs10498433	chr14	52289530	SLC5A7	60482	0	trans
rs17091014	chr14	56562713	SLC5A7	60482	0	trans
rs10483833	chr14	71165243	SLC5A7	60482	0.03	trans
rs2533045	chr14	72320904	SLC5A7	60482	0.16	trans
rs1642278	chr14	87273027	SLC5A7	60482	0.16	trans
rs1743505	chr14	96143407	SLC5A7	60482	4.771E-4	trans
rs6576402	chr15	25310439	SLC5A7	60482	0.15	trans
rs16939821	chr15	58449860	SLC5A7	60482	0	trans
rs16946329	chr15	63324362	SLC5A7	60482	7.838E-4	trans
rs16946913	chr15	63653889	SLC5A7	60482	0	trans
rs7174517	chr15	87256320	SLC5A7	60482	0.08	trans
rs17694187	chr15	91881259	SLC5A7	60482	0.02	trans
rs1036529	chr15	97071598	SLC5A7	60482	0.12	trans
rs920567	chr15	98248480	SLC5A7	60482	0.06	trans
rs931891	chr15	98293206	SLC5A7	60482	0.07	trans
rs6598553	chr15	99339208	SLC5A7	60482	0.07	trans
rs962253	chr15	99339832	SLC5A7	60482	0.08	trans
rs2684763	chr15	99365485	SLC5A7	60482	0.08	trans
rs17634236	chr16	5067148	SLC5A7	60482	0.04	trans
rs4786811	chr16	6132786	SLC5A7	60482	0.05	trans
rs17142983	chr16	7294508	SLC5A7	60482	6.958E-4	trans
rs7196563	chr16	7333407	SLC5A7	60482	0.01	trans
rs7191914	chr16	7333464	SLC5A7	60482	0.01	trans
rs11865410	chr16	7333565	SLC5A7	60482	0.01	trans
rs8056710	chr16	7447629	SLC5A7	60482	0	trans
rs16972025	chr16	19461881	SLC5A7	60482	0.03	trans
rs1557515	chr16	19462965	SLC5A7	60482	0.15	trans
rs12596831	chr16	23385256	SLC5A7	60482	0.12	trans
snp_a-4250222		0	SLC5A7	60482	0.05	trans
rs7195151	chr16	61082370	SLC5A7	60482	0.07	trans
rs6499075	chr16	66387395	SLC5A7	60482	0.03	trans
rs17666993	chr16	72146665	SLC5A7	60482	0.1	trans
rs17667053	chr16	72147430	SLC5A7	60482	0.15	trans
rs7192551	chr16	74750141	SLC5A7	60482	0.14	trans
rs8051077	chr16	75036432	SLC5A7	60482	0.05	trans
rs11648264	chr16	79085004	SLC5A7	60482	0.18	trans
rs519507	chr16	88963599	SLC5A7	60482	0.14	trans
rs1391765	chr17	8297465	SLC5A7	60482	0.02	trans
rs17798004	chr18	70665382	SLC5A7	60482	0.01	trans
rs17736134	chr18	70665805	SLC5A7	60482	4.865E-4	trans
rs2469060	chr18	70673106	SLC5A7	60482	4.865E-4	trans
rs2469009	chr18	70713334	SLC5A7	60482	2.864E-4	trans
rs9962412	chr18	73427437	SLC5A7	60482	0.04	trans
rs9965745	chr18	73429162	SLC5A7	60482	0.05	trans
rs1943200	chr18	73462540	SLC5A7	60482	0.05	trans
rs8110995	chr19	40863841	SLC5A7	60482	0.17	trans
rs2288529	chr19	55665688	SLC5A7	60482	0.12	trans
rs12461195	chr19	55688575	SLC5A7	60482	0.11	trans
rs7344216		0	SLC5A7	60482	0.01	trans
rs6042548	chr20	14125226	SLC5A7	60482	0.04	trans
rs4814288	chr20	14186386	SLC5A7	60482	0.01	trans
rs6514759		0	SLC5A7	60482	0	trans
rs16979534	chr20	18713087	SLC5A7	60482	0.09	trans
rs409642	chr20	54250273	SLC5A7	60482	8.373E-5	trans
snp_a-2019049		0	SLC5A7	60482	0.02	trans
rs7275460	chr21	41447057	SLC5A7	60482	0.01	trans
rs2837496	chr21	41576838	SLC5A7	60482	0.07	trans
rs2837506	chr21	41581683	SLC5A7	60482	0.07	trans
rs17809705	chr22	18552661	SLC5A7	60482	0.12	trans
rs16993271	chr22	34307850	SLC5A7	60482	0.03	trans
rs17003586	chr22	43667457	SLC5A7	60482	2.765E-4	trans
rs2269667	chr22	43699291	SLC5A7	60482	0	trans
rs6007794	chr22	46685016	SLC5A7	60482	0.01	trans
rs7290732	chr22	46691902	SLC5A7	60482	0	trans
rs929048	chr22	47851756	SLC5A7	60482	0.09	trans
rs6008234	chr22	47882762	SLC5A7	60482	0.12	trans
rs5960312	chrX	54576348	SLC5A7	60482	0.05	trans
rs11091332		0	SLC5A7	60482	0.02	trans
rs5961111	chrX	54659538	SLC5A7	60482	0.01	trans
rs7055735	chrX	85687566	SLC5A7	60482	0.13	trans
rs5920627	chrX	97385064	SLC5A7	60482	0.02	trans
snp_a-2027825		0	SLC5A7	60482	6.897E-4	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005307	choline:sodium symporter activity	IMP		12237312
GO:0005215	transporter activity	IEA		-
GO:0015293	symporter activity	IEA		-
GO:0031402	sodium ion binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007274	neuromuscular synaptic transmission	IEA	neuron, Synap (GO term level: 7)	-
GO:0007271	synaptic transmission, cholinergic	IEA	neuron, Cholinergic, Synap, Neurotransmitter (GO term level: 7)	-
GO:0008292	acetylcholine biosynthetic process	IMP	Neurotransmitter (GO term level: 10)	11068039
GO:0015871	choline transport	IEA	Neurotransmitter (GO term level: 6)	-
GO:0006814	sodium ion transport	IEA		-
GO:0006811	ion transport	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0016021	integral to membrane	IDA		11027560
GO:0005886	plasma membrane	IDA		12237312

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	186	155	All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM	279	221	All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RELEASE CYCLE	34	30	All SZGR 2.0 genes in this pathway
REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	10	9	All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES	413	270	All SZGR 2.0 genes in this pathway
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT	241	157	All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	89	54	All SZGR 2.0 genes in this pathway
REACTOME AMINE COMPOUND SLC TRANSPORTERS	27	16	All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS E UP	97	60	All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP	390	236	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D	882	506	All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM A	182	108	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-135	1203	1209	m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	1203	1209	m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-19	138	144	1A	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	138	144	1A	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: SLC5A7