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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: RPS6KB1

Summary

GeneID

6198

Symbol

RPS6KB1

Synonyms

PS6K|S6K|S6K1|STK14A|p70(S6K)-alpha|p70-S6K|p70-alpha

Description

ribosomal protein S6 kinase, 70kDa, polypeptide 1

Locus tag

Gene type

protein-coding

Map location

17q23.1

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0493

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

TRUB2

0.60

0.54

ATP5G1

0.59

0.53

GPX4

0.59

0.50

ACY1

0.58

0.52

SLC2A11

0.58

0.53

CYC1

0.58

0.48

ABHD14A

0.57

0.53

FAM58A

0.57

0.51

MTX1

0.57

0.52

ERI3

0.57

0.50

Top 10 negatively co-expressed genes

SEC62

-0.30

-0.35

EIF5B

-0.29

-0.31

AF347015.18

-0.26

-0.24

ZNHIT6

-0.26

-0.22

MT-ATP8

-0.26

-0.22

GIMAP8

-0.26

SFRS12

-0.25

-0.22

MYO6

-0.25

-0.22

CALD1

-0.24

-0.22

AC016705.1

-0.22

-0.16

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0005524

ATP binding

IEA

GO:0004672

protein kinase activity

IEA

GO:0004674

protein serine/threonine kinase activity

IEA

GO:0016740

transferase activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006468

protein amino acid phosphorylation

IEA

GO:0007281

germ cell development

IEA

GO:0007165

signal transduction

IEA

GO:0007165

signal transduction

TAS

1922062

GO:0043491

protein kinase B signaling cascade

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0019717

synaptosome

IEA

Synap, Brain (GO term level: 7)

GO:0045202

synapse

IEA

neuron, Synap, Neurotransmitter, Glial (GO term level: 2)

GO:0005829

cytosol

EXP

15314020 |15809305

GO:0005840

ribosome

IEA

GO:0005737

cytoplasm

IEA

GO:0030054

cell junction

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTA1	ACTA \| ASMA \| CFTD \| CFTD1 \| CFTDM \| MPFD \| NEM1 \| NEM2 \| NEM3	actin, alpha 1, skeletal muscle	Reconstituted Complex	BioGRID	15149849
AKT1	AKT \| MGC99656 \| PKB \| PKB-ALPHA \| PRKBA \| RAC \| RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1	-	HPRD	11438723
AKT1	AKT \| MGC99656 \| PKB \| PKB-ALPHA \| PRKBA \| RAC \| RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1	Co-purification	BioGRID	15149849
BTK	AGMX1 \| AT \| ATK \| BPK \| IMD1 \| MGC126261 \| MGC126262 \| PSCTK1 \| XLA	Bruton agammaglobulinemia tyrosine kinase	Biochemical Activity	BioGRID	16640565
CDC42	CDC42Hs \| G25K	cell division cycle 42 (GTP binding protein, 25kDa)	-	HPRD	11438723
COASY	DPCK \| FLJ35179 \| NBP \| PPAT \| UKR1 \| pOV-2	Coenzyme A synthase	Affinity Capture-Western Reconstituted Complex	BioGRID	15589845
CSNK2A1	CK2A1 \| CKII	casein kinase 2, alpha 1 polypeptide	Reconstituted Complex	BioGRID	16895915
CSNK2B	CK2B \| CK2N \| CSK2B \| G5A \| MGC138222 \| MGC138224	casein kinase 2, beta polypeptide	Affinity Capture-Western Reconstituted Complex	BioGRID	16895915
EEF2K	HSU93850 \| MGC45041 \| eEF-2K	eukaryotic elongation factor-2 kinase	Reconstituted Complex	BioGRID	11500364
EIF3B	EIF3-ETA \| EIF3-P110 \| EIF3-P116 \| EIF3S9 \| MGC104664 \| MGC131875 \| PRT1	eukaryotic translation initiation factor 3, subunit B	Affinity Capture-Western	BioGRID	16286006
EIF3C	EIF3S8 \| FLJ78287 \| MGC189744 \| eIF3-p110	eukaryotic translation initiation factor 3, subunit C	Affinity Capture-Western	BioGRID	16286006
EIF3F	EIF3S5 \| eIF3-p47	eukaryotic translation initiation factor 3, subunit F	Affinity Capture-MS	BioGRID	16286006
EIF4EBP1	4E-BP1 \| 4EBP1 \| BP-1 \| MGC4316 \| PHAS-I	eukaryotic translation initiation factor 4E binding protein 1	-	HPRD	11438723
FRAP1	FLJ44809 \| FRAP \| FRAP2 \| MTOR \| RAFT1 \| RAPT1	FK506 binding protein 12-rapamycin associated protein 1	Affinity Capture-Western Biochemical Activity Reconstituted Complex	BioGRID	9465032 \|10567431 \|10971657 \|11914378 \|12150925 \|12150926 \|12604610 \|14679009 \|15809305 \|15854902 \|15896331 \|15899889 \|15905173 \|16183647 \|16922504
GDI2P	-	GDP dissociation inhibitor 2 pseudogene	Biochemical Activity Reconstituted Complex	BioGRID	15249583 \|16914728
KIAA1303	-	raptor	Affinity Capture-Western Reconstituted Complex	BioGRID	12150926 \|12604610 \|15809305 \|16837165
LYN	FLJ26625 \| JTK8	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	Biochemical Activity	BioGRID	16640565
NCBP1	CBP80 \| MGC2087 \| NCBP	nuclear cap binding protein subunit 1, 80kDa	-	HPRD	10973943
PDK1	-	pyruvate dehydrogenase kinase, isozyme 1	Reconstituted Complex	BioGRID	11733037
PDPK1	MGC20087 \| MGC35290 \| PDK1 \| PRO0461	3-phosphoinositide dependent protein kinase-1	-	HPRD	11438723
POLDIP3	KIAA1649 \| PDIP46 \| SKAR	polymerase (DNA-directed), delta interacting protein 3	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	15341740
PPP1R9A	FLJ20068 \| KIAA1222 \| NRB1 \| NRBI \| Neurabin-I	protein phosphatase 1, regulatory (inhibitor) subunit 9A	-	HPRD	12052877
PPP2CA	PP2Ac \| PP2CA \| RP-C	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	-	HPRD	11438723
PPP2R2A	B55-ALPHA \| B55A \| FLJ26613 \| MGC52248 \| PR52A \| PR55A	protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform	Affinity Capture-Western	BioGRID	10200280 \|16899564
PRKCZ	PKC-ZETA \| PKC2	protein kinase C, zeta	Affinity Capture-Western	BioGRID	16931574
RAC1	MGC111543 \| MIG5 \| TC-25 \| p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	-	HPRD	11438723
RICTOR	DKFZp686B11164 \| KIAA1999 \| MGC39830 \| mAVO3	rapamycin-insensitive companion of mTOR	Reconstituted Complex	BioGRID	15809305
RPS6	-	ribosomal protein S6	RPS6KB1 (S6K1) interacts with and phosphorylates RPS6.	BIND	12586835
RPS6	-	ribosomal protein S6	-	HPRD	11438723
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Biochemical Activity	BioGRID	16640565
SYK	DKFZp313N1010 \| FLJ25043 \| FLJ37489	spleen tyrosine kinase	Biochemical Activity	BioGRID	16640565
TERT	EST2 \| TCS1 \| TP2 \| TRT \| hEST2	telomerase reverse transcriptase	Affinity Capture-Western	BioGRID	15843522
TRAF4	CART1 \| MLN62 \| RNF83	TNF receptor-associated factor 4	-	HPRD,BioGRID	12801526
XPO1	CRM1 \| DKFZp686B1823	exportin 1 (CRM1 homolog, yeast)	Affinity Capture-Western	BioGRID	16895915

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	1405	1412	1A,m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124.1	1405	1412	1A,m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	1405	1411	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
				hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
				hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
				hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-128	2220	2227	1A,m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
				hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
				hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
				hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-129-5p	172	179	1A,m8	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
miR-129-5p	172	179	1A,m8	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-135	1667	1674	1A,m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	1667	1674	1A,m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-140	672	678	1A	hsa-miR-140^brain	AGUGGUUUUACCCUAUGGUAG
miR-142-5p	1464	1470	1A	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-145	888	894	1A	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-153	2503	2510	1A,m8	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-181	3596	3603	1A,m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
				hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-186	1677	1684	1A,m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-186	1677	1684	1A,m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-199	887	893	1A	hsa-miR-199a	CCCAGUGUUCAGACUACCUGUUC
miR-199	887	893	1A	hsa-miR-199b	CCCAGUGUUUAGACUAUCUGUUC
miR-200bc/429	291	298	1A,m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
				hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
				hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-218	2493	2499	m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-218	2493	2499	m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-223	285	292	1A,m8	hsa-miR-223	UGUCAGUUUGUCAAAUACCCC
miR-24*	366	372	1A	hsa-miR-189	GUGCCUACUGAGCUGAUAUCAGU
miR-25/32/92/363/367	2506	2512	1A	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
				hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-27	2450	2457	1A,m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
				hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
				hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
				hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-299-5p	2799	2805	1A	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-320	1462	1468	1A	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-33	652	658	1A	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
miR-33	652	658	1A	hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-342	51	57	m8	hsa-miR-342^brain	UCUCACACAGAAAUCGCACCCGUC
miR-34b	2146	2152	m8	hsa-miR-34b	UAGGCAGUGUCAUUAGCUGAUUG
miR-363	489	496	1A,m8	hsa-miR-363	AUUGCACGGUAUCCAUCUGUAA
miR-363	489	496	1A,m8	hsa-miR-363	AUUGCACGGUAUCCAUCUGUAA
miR-369-3p	3377	3383	m8	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-377	50	56	m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-377	50	56	m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-381	3556	3562	m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-384	1290	1296	1A	hsa-miR-384	AUUCCUAGAAAUUGUUCAUA
miR-409-3p	2999	3005	m8	hsa-miR-409-3p	CGAAUGUUGCUCGGUGAACCCCU
miR-410	514	520	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-448	2504	2510	1A	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-450	172	178	1A	hsa-miR-450	UUUUUGCGAUGUGUUCCUAAUA
miR-452	491	498	1A,m8	hsa-miR-452	UGUUUGCAGAGGAAACUGAGAC
miR-496	3599	3605	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-500	169	175	1A	hsa-miR-500	AUGCACCUGGGCAAGGAUUCUG
miR-505	3169	3175	1A	hsa-miR-505	GUCAACACUUGCUGGUUUCCUC
miR-542-3p	3301	3307	1A	hsa-miR-542-3p	UGUGACAGAUUGAUAACUGAAA
miR-542-3p	3301	3307	1A	hsa-miR-542-3p	UGUGACAGAUUGAUAACUGAAA
miR-7	1255	1262	1A,m8	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.