Gene Page: RYK

Summary
GeneID  6259
Symbol  RYK
Synonyms  D3S3195|JTK5|JTK5A|RYK1
Description  RYK receptor-like tyrosine kinase
See related  HGNC:10481|MIM:600524|Ensembl:ENSG00000163785|HPRD:02751|
Locus tag  -
Gene type  protein-coding
Map location  3q22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
EIF2AK10.880.79
SEC23B0.870.82
COPA0.870.82
FTSJD20.870.79
HDLBP0.860.78
ARFGAP20.860.79
WBP110.860.81
COPG0.860.83
IMMT0.860.77
USP110.860.81
Top 10 negatively co-expressed genes
AF347015.21-0.82-0.70
MT-CO2-0.77-0.68
AF347015.31-0.75-0.68
HIGD1B-0.73-0.65
AF347015.8-0.73-0.65
AF347015.33-0.71-0.65
MT-CYB-0.71-0.63
IFI27-0.70-0.60
AF347015.2-0.70-0.64
C1orf54-0.69-0.62
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004714transmembrane receptor protein tyrosine kinase activityTASneurite (GO term level: 8)8386829 
GO:0000166nucleotide bindingIEA-
GO:0004872receptor activityIEA-
GO:0005524ATP bindingIEA-
GO:0004713protein tyrosine kinase activityIEA-
GO:0016740transferase activityIEA-
GO:0042813Wnt receptor activityIEA-
GO:0017147Wnt-protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007409axonogenesisIEAneuron, axon, neurite (GO term level: 12)-
GO:0006468protein amino acid phosphorylationIEA-
GO:0006468protein amino acid phosphorylationNAS8726462 
GO:0007165signal transductionTAS8386829 
GO:0048705skeletal system morphogenesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005624membrane fractionIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS8386829 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EPHB2CAPB | DRT | EPHT3 | ERK | Hek5 | MGC87492 | PCBC | Tyro5EPH receptor B2-HPRD,BioGRID11956217 
EPHB3ETK2 | HEK2 | TYRO6EPH receptor B3-HPRD,BioGRID11956217 
FZD8FZ-8 | hFZ8frizzled homolog 8 (Drosophila)Frizzled-8 interacts with Ryk. This interaction was modeled on a demonstrated interaction between Frizzled-8 and Ryk from unspecified species.BIND15454084 
WNT1INT1wingless-type MMTV integration site family, member 1Ryk interacts with Wnt-1. This interaction was modeled on a demonstrated interaction between Ryk and Wnt-1 from unspecified species.BIND15454084 
WNT3AMGC119418 | MGC119419 | MGC119420wingless-type MMTV integration site family, member 3ARyk interacts with Wnt-3a. This interaction was modeled on a demonstrated interaction between Ryk and Wnt-3a from unspecified species.BIND15454084 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-269899951Ahsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-96346352m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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