Gene Page: SCNN1B

Summary
GeneID  6338
Symbol  SCNN1B
Synonyms  ENaCb|ENaCbeta|SCNEB
Description  sodium channel, nonvoltage-gated 1, beta
See related  HGNC:10600|MIM:600760|Ensembl:ENSG00000168447|HPRD:02861|
Locus tag  hCG_23853
Gene type  protein-coding
Map location  16p12.2-p12.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
EDNRB0.660.52
IGSF10.630.53
KCNJ160.620.58
BBOX10.610.53
AQP40.610.57
MAOA0.600.56
FIBIN0.600.48
GJA10.600.53
BCHE0.590.45
TMEM1000.590.50
Top 10 negatively co-expressed genes
RTF1-0.34-0.36
ARL4D-0.32-0.32
PLEKHO1-0.31-0.31
BZW2-0.30-0.35
PABPN1-0.30-0.37
ZBTB8A-0.30-0.26
NOL4-0.30-0.29
GMEB1-0.30-0.28
BCL7A-0.30-0.30
ZNF589-0.30-0.28
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI11244092 
GO:0005216ion channel activityIEA-
GO:0015280amiloride-sensitive sodium channel activityTAS9118951 
GO:0031402sodium ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007588excretionTAS9118951 
GO:0006814sodium ion transportTAS8521520 
GO:0006811ion transportIEA-
GO:0050896response to stimulusIEA-
GO:0050909sensory perception of tasteIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
GO:0016324apical plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CNTN1F3 | GP135contactin 1-HPRD11567041 |14761957 
HECW1KIAA0322 | NEDL1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1Far WesternBioGRID11244092 
ITCHAIF4 | AIP4 | NAPP1 | dJ468O1.1itchy E3 ubiquitin protein ligase homolog (mouse)Far WesternBioGRID11244092 
NEDD4KIAA0093 | MGC176705 | NEDD4-1 | RPF1neural precursor cell expressed, developmentally down-regulated 4-HPRD10212229 |10642508 
|11359767|10642508 
-HPRD,BioGRID10642508 
NEDD4LFLJ33870 | KIAA0439 | NEDD4-2 | RSP5 | hNedd4-2neural precursor cell expressed, developmentally down-regulated 4-like-HPRD,BioGRID11244092 
SCNN1AENaCa | ENaCalpha | FLJ21883 | SCNEA | SCNN1sodium channel, nonvoltage-gated 1 alpha-HPRD8986818 
SCNN1DENaCd | ENaCdelta | MGC149710 | MGC149711 | SCNED | dNaChsodium channel, nonvoltage-gated 1, delta-HPRD7499195 
SCNN1GENaCg | ENaCgamma | PHA1 | SCNEGsodium channel, nonvoltage-gated 1, gamma-HPRD8986818 
STX1AHPC-1 | STX1 | p35-1syntaxin 1A (brain)Affinity Capture-WesternBioGRID14996668 
-HPRD11845306 
WWP2AIP2 | WWp2-likeWW domain containing E3 ubiquitin protein ligase 2-HPRD,BioGRID12167593 
 


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