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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: SH3GL2

Summary

GeneID

6456

Symbol

SH3GL2

Synonyms

CNSA2|EEN-B1|FLJ20276|FLJ25015|SH3D2A|SH3P4

Description

SH3-domain GRB2-like 2

Locus tag

Gene type

protein-coding

Map location

9p22

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]

Click to show detail

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.5624

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0008289

lipid binding

IEA

GO:0042802

identical protein binding

IPI

16115810

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007417

central nervous system development

TAS

Brain (GO term level: 6)

9169142

GO:0007165

signal transduction

TAS

9169142

GO:0006897

endocytosis

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005829

cytosol

EXP

10567358 |11894095 |12218189
|15962011

GO:0005737

cytoplasm

IEA

GO:0005886

plasma membrane

EXP

11157096

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTG1	ACT \| ACTG \| DFNA20 \| DFNA26	actin, gamma 1	Two-hybrid	BioGRID	16169070
ADAM12	MCMP \| MCMPMltna \| MLTN \| MLTNA	ADAM metallopeptidase domain 12	-	HPRD	10531379
ADAM15	MDC15	ADAM metallopeptidase domain 15	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10531379
ADAM19	FKSG34 \| MADDAM \| MLTNB	ADAM metallopeptidase domain 19 (meltrin beta)	Two-hybrid	BioGRID	10531379
ADAM9	KIAA0021 \| MCMP \| MDC9 \| Mltng	ADAM metallopeptidase domain 9 (meltrin gamma)	-	HPRD,BioGRID	10531379
ADRB1	ADRB1R \| B1AR \| BETA1AR \| RHR	adrenergic, beta-1-, receptor	Beta-1-AR interacts with SH3p4. This interaction was modeled on a demonstrated interaction between human Beta-1-AR and rat or cow SH3p4.	BIND	10535961
AMPH	AMPH1	amphiphysin	Reconstituted Complex	BioGRID	9341169 \|12456676
AMPH	AMPH1	amphiphysin	-	HPRD	9315708
BIN1	AMPH2 \| AMPHL \| DKFZp547F068 \| MGC10367 \| SH3P9	bridging integrator 1	-	HPRD	9315708
BIN1	AMPH2 \| AMPHL \| DKFZp547F068 \| MGC10367 \| SH3P9	bridging integrator 1	Reconstituted Complex	BioGRID	12456676
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	-	HPRD	11894096
CBL	C-CBL \| CBL2 \| RNF55		Affinity Capture-Western	BioGRID	11894095
DNM1	DNM	dynamin 1	Reconstituted Complex	BioGRID	9341169 \|12456676
			-	HPRD	11877424
			-	HPRD	9238017 \|11877424
EGFL6	DKFZp564P2063 \| MAEG \| W80	EGF-like-domain, multiple 6	Two-hybrid	BioGRID	16169070
EMD	EDMD \| LEMD5 \| STA	emerin	Two-hybrid	BioGRID	16169070
ERH	DROER \| FLJ27340	enhancer of rudimentary homolog (Drosophila)	Two-hybrid	BioGRID	16169070
HLA-DQA1	CD \| CELIAC1 \| DQ-A1 \| FLJ27088 \| FLJ27328 \| GSE \| HLA-DQA \| MGC149527	major histocompatibility complex, class II, DQ alpha 1	Two-hybrid	BioGRID	16169070
IL6	BSF2 \| HGF \| HSF \| IFNB2 \| IL-6	interleukin 6 (interferon, beta 2)	Two-hybrid	BioGRID	16169070
MAP4K3	GLK \| MAPKKKK3 \| RAB8IPL1	mitogen-activated protein kinase kinase kinase kinase 3	-	HPRD	11384986
PDCD6IP	AIP1 \| Alix \| DRIP4 \| HP95 \| MGC17003	programmed cell death 6 interacting protein	-	HPRD	12034747
SH3KBP1	CIN85 \| GIG10 \| MIG18	SH3-domain kinase binding protein 1	-	HPRD,BioGRID	12218189
SH3KBP1	CIN85 \| GIG10 \| MIG18	SH3-domain kinase binding protein 1	CIN85 interacts with endophilin A1. This interaction was modeled on a demonstrated interaction between human CIN85 and mouse endophilin A1.	BIND	11894095
SYN1	SYN1a \| SYN1b \| SYNI	synapsin I	Reconstituted Complex	BioGRID	12456676
SYNJ1	INPP5G	synaptojanin 1	Affinity Capture-Western Reconstituted Complex	BioGRID	9341169
SYNJ2	INPP5H \| KIAA0348 \| MGC44422	synaptojanin 2	Reconstituted Complex	BioGRID	12456676
TCEA2	TFIIS	transcription elongation factor A (SII), 2	Two-hybrid	BioGRID	16169070

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-133	1011	1017	1A	hsa-miR-133a	UUGGUCCCCUUCAACCAGCUGU
miR-133	1011	1017	1A	hsa-miR-133b	UUGGUCCCCUUCAACCAGCUA
miR-138	467	474	1A,m8	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-146	263	270	1A,m8	hsa-miR-146a	UGAGAACUGAAUUCCAUGGGUU
miR-146	263	270	1A,m8	hsa-miR-146b^brain	UGAGAACUGAAUUCCAUAGGCU
miR-15/16/195/424/497	1255	1261	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-330	56	62	m8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-448	1062	1069	1A,m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.