Gene Page: SIM2

Summary
GeneID  6493
Symbol  SIM2
Synonyms  MGC119447|SIM|bHLHe15
Description  single-minded homolog 2 (Drosophila)
See related  HGNC:10883|MIM:600892|Ensembl:ENSG00000159263|HPRD:02935|
Locus tag  -
Gene type  protein-coding
Map location  21q22.2|21q22.13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
AFAP1L20.810.85
TMEM184B0.800.84
PER30.790.85
TOM1L20.790.81
CTSA0.790.84
SIRPA0.780.87
MAP3K50.780.84
SYT150.770.80
TSPAN70.770.81
SLC20A20.770.84
Top 10 negatively co-expressed genes
RPS13P2-0.54-0.63
RPL24-0.54-0.66
RPS23-0.53-0.64
RPS3AP47-0.53-0.63
RPL31-0.53-0.63
RPL27-0.52-0.62
RPS8-0.52-0.62
UXT-0.52-0.61
RPS27A-0.52-0.66
RPS6-0.52-0.63
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004871signal transducer activityIEA-
GO:0003700transcription factor activityTAS8661114 |9199934 
GO:0005515protein bindingIEA-
GO:0016564transcription repressor activityIEA-
GO:0046982protein heterodimerization activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentTASneurite (GO term level: 5)9199934 
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0007165signal transductionIEA-
GO:0009880embryonic pattern specificationIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
GO:0030324lung developmentIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARNTHIF-1beta | HIF1B | HIF1BETA | TANGO | bHLHe2aryl hydrocarbon receptor nuclear translocator-HPRD,BioGRID9020169 |9271372 
|11782478 
ARNT2KIAA0307 | bHLHe1aryl-hydrocarbon receptor nuclear translocator 2Two-hybridBioGRID14701734 
EPOEP | MGC138142erythropoietinSIM2 interacts with the hypoxia-inducible enhancer of the EPO gene. This interaction was modeled on a demonstrated interaction between mouse SIM2 and the human EPO enhancer.BIND11782478 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-138105910661A,m8hsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-141/200a10651071m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-1557377431Ahsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-18713719m8hsa-miR-18aUAAGGUGCAUCUAGUGCAGAUA
hsa-miR-18bUAAGGUGCAUCUAGUGCAGUUA
miR-25/32/92/363/3678939001A,m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-3657367421Ahsa-miR-365UAAUGCCCCUAAAAAUCCUUAU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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