Gene Page: SIX1

Summary
GeneID  6495
Symbol  SIX1
Synonyms  BOS3|DFNA23|TIP39
Description  SIX homeobox 1
See related  HGNC:10887|MIM:601205|Ensembl:ENSG00000126778|HPRD:03125|
Locus tag  -
Gene type  protein-coding
Map location  14q23.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIEA-
GO:0005515protein bindingIPI16189514 
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0045664regulation of neuron differentiationIEAneuron, neurogenesis (GO term level: 9)-
GO:0007519skeletal muscle developmentIEAneuron (GO term level: 8)-
GO:0001657ureteric bud developmentIEA-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0007517muscle developmentTAS8617500 
GO:0007605sensory perception of soundIEA-
GO:0007389pattern specification processIEA-
GO:0030855epithelial cell differentiationIEA-
GO:0042472inner ear morphogenesisIEA-
GO:0030878thyroid gland developmentIEA-
GO:0048538thymus developmentIEA-
GO:0048704embryonic skeletal system morphogenesisIEA-
GO:0051451myoblast migrationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005667transcription factor complexIEA-
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AESAES-1 | AES-2 | ESP1 | GRG | GRG5 | TLE5amino-terminal enhancer of splitSIX1 interacts with AES.BIND12441302 
CCDC85BDIPAcoiled-coil domain containing 85BTwo-hybridBioGRID16189514 
DACH1DACH | FLJ10138dachshund homolog 1 (Drosophila)-HPRD14628042 
EYA1BOP | BOR | MGC141875eyes absent homolog 1 (Drosophila)-HPRD,BioGRID11734542 |12874121 
EYA2EAB1 | MGC10614eyes absent homolog 2 (Drosophila)-HPRD,BioGRID10906137 
EYA3DKFZp686C132eyes absent homolog 3 (Drosophila)-HPRD12215533 
MDFII-MF | I-mfaMyoD family inhibitorAffinity Capture-Western
Two-hybrid		BioGRID16189514 
SIX1BOS3 | DFNA23 | TIP39SIX homeobox 1-HPRD11734542 
TLE1ESG | ESG1 | GRG1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)SIX1 interacts with TLE1.BIND12441302 
 


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