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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: SIX3

Summary

GeneID

6496

Symbol

SIX3

Synonyms

HPE2

Description

SIX homeobox 3

Locus tag

Gene type

protein-coding

Map location

2p16-p21

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

COL1A2

0.86

0.46

OGN

0.85

0.45

COL1A1

0.85

0.47

COL3A1

0.85

0.47

OSR1

0.84

0.42

COL6A3

0.84

0.47

BNC2

0.83

0.35

SCARA5

0.82

0.39

GJB2

0.81

0.33

ALX4

0.81

0.43

Top 10 negatively co-expressed genes

LHPP

-0.27

-0.16

C5orf53

-0.25

-0.27

REEP6

-0.25

-0.14

HLA-C

-0.25

-0.20

HEPN1

-0.24

-0.19

AF347015.33

-0.24

-0.27

MT-CO2

-0.24

-0.29

AF347015.31

-0.24

-0.28

TSC22D4

-0.24

-0.20

MRPL41

-0.24

-0.17

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003705

RNA polymerase II transcription factor activity, enhancer binding

IEA

GO:0005515

protein binding

IEA

GO:0016564

transcription repressor activity

IEA

GO:0043565

sequence-specific DNA binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007420

brain development

TAS

Brain (GO term level: 7)

10369266

GO:0006355

regulation of transcription, DNA-dependent

IEA

GO:0007601

visual perception

TAS

10369266

GO:0007275

multicellular organismal development

IEA

GO:0016481

negative regulation of transcription

IEA

GO:0030178

negative regulation of Wnt receptor signaling pathway

IEA

GO:0043010

camera-type eye development

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AES	AES-1 \| AES-2 \| ESP1 \| GRG \| GRG5 \| TLE5	amino-terminal enhancer of split	Reconstituted Complex Two-hybrid	BioGRID	12441302
			-	HPRD	12050133
			SIX3 interacts with AES.	BIND	12441302
EYA1	BOP \| BOR \| MGC141875	eyes absent homolog 1 (Drosophila)	-	HPRD	10490620
GMNN	Gem \| RP3-369A17.3	geminin, DNA replication inhibitor	geminin interacts with Six3	BIND	14973488
NR4A3	CHN \| CSMF \| MINOR \| NOR1 \| TEC	nuclear receptor subfamily 4, group A, member 3	-	HPRD,BioGRID	11173923 \|12543801
PAX6	AN \| AN2 \| D11S812E \| MGC17209 \| MGDA \| WAGR	paired box 6	-	HPRD,BioGRID	11069920
TLE1	ESG \| ESG1 \| GRG1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	SIX3 interacts with TLE1.	BIND	12441302
TLE1	ESG \| ESG1 \| GRG1		-	HPRD,BioGRID	12441302
TLE3	ESG \| ESG3 \| FLJ39460 \| GRG3 \| HsT18976 \| KIAA1547	transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)	SIX3 interacts with TLE3.	BIND	12441302

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-375	109	115	1A	hsa-miR-375	UUUGUUCGUUCGGCUCGCGUGA
miR-381	330	336	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-488	411	417	m8	hsa-miR-488	CCCAGAUAAUGGCACUCUCAA
miR-544	305	311	1A	hsa-miR-544	AUUCUGCAUUUUUAGCAAGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.