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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: BMP2

Summary

GeneID

650

Symbol

BMP2

Synonyms

BMP2A

Description

bone morphogenetic protein 2

Locus tag

Gene type

protein-coding

Map location

20p12

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

CXCL12

0.74

0.70

FLVCR2

0.68

0.55

COL6A2

0.67

0.57

VCL

0.67

0.63

OLFML3

0.67

0.54

AL137026.3

0.66

0.51

COL5A1

0.66

0.57

ADAMTS12

0.65

0.46

ISLR

0.64

0.68

NID1

0.64

0.47

Top 10 negatively co-expressed genes

SYCP3

-0.26

C11orf51

-0.25

-0.35

MT1G

-0.25

-0.05

CLEC2B

-0.23

-0.07

S100A13

-0.23

-0.01

NDUFB1

-0.23

-0.28

ZBTB8OS

-0.22

-0.29

AL022328.1

-0.22

-0.18

AL353354.3

-0.22

-0.28

RP9P

-0.22

-0.43

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005125

cytokine activity

IEA

GO:0008083

growth factor activity

IEA

GO:0016566

specific transcriptional repressor activity

IDA

15254224

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0048711

positive regulation of astrocyte differentiation

IEA

astrocyte, Glial (GO term level: 12)

GO:0001658

ureteric bud branching

IEA

GO:0001837

epithelial to mesenchymal transition

IDA

15110716

GO:0007267

cell-cell signaling

TAS

2315314

GO:0009887

organ morphogenesis

IEA

GO:0008285

negative regulation of cell proliferation

IEA

GO:0009790

embryonic development

IEA

GO:0006954

inflammatory response

IEA

GO:0042475

odontogenesis of dentine-containing tooth

IEA

GO:0030501

positive regulation of bone mineralization

IDA

18436533

GO:0030509

BMP signaling pathway

EXP

15621726

GO:0030509

BMP signaling pathway

IEA

GO:0051216

cartilage development

IEA

GO:0035051

cardiac cell differentiation

IDA

15110716

GO:0032582

negative regulation of gene-specific transcription

IDA

15254224

GO:0040007

growth

IEA

GO:0045165

cell fate commitment

IEA

GO:0045941

positive regulation of transcription

IDA

16049014

GO:0045786

negative regulation of cell cycle

IDA

11502704

GO:0045669

positive regulation of osteoblast differentiation

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005576

extracellular region

EXP

17029022 |17356069

GO:0005576

extracellular region

IEA

GO:0005615

extracellular space

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTR2	ARP2	ARP2 actin-related protein 2 homolog (yeast)	Reconstituted Complex	BioGRID	10880444
ACVR1	ACTRI \| ACVR1A \| ACVRLK2 \| ALK2 \| FOP \| SKR1 \| TSRI	activin A receptor, type I	-	HPRD	8006002
ASCL1	ASH1 \| HASH1 \| MASH1 \| bHLHa46	achaete-scute complex homolog 1 (Drosophila)	-	HPRD	9197246
BMPER	CRIM3 \| CV-2 \| CV2	BMP binding endothelial regulator	-	HPRD	12897139
BMPR1A	10q23del \| ACVRLK3 \| ALK3 \| CD292	bone morphogenetic protein receptor, type IA	Co-crystal Structure Reconstituted Complex	BioGRID	10692589 \|10712517 \|10880444 \|11263668
BMPR1A	10q23del \| ACVRLK3 \| ALK3 \| CD292	bone morphogenetic protein receptor, type IA	-	HPRD	10692589 \|10881198 \|11263668\|11263668
BMPR1B	ALK-6 \| ALK6 \| CDw293	bone morphogenetic protein receptor, type IB	Reconstituted Complex	BioGRID	10712517
BMPR1B	ALK-6 \| ALK6 \| CDw293	bone morphogenetic protein receptor, type IB	-	HPRD	9872992
BMPR2	BMPR-II \| BMPR3 \| BMR2 \| BRK-3 \| FLJ41585 \| FLJ76945 \| PPH1 \| T-ALK	bone morphogenetic protein receptor, type II (serine/threonine kinase)	-	HPRD,BioGRID	10880444
COL2A1	ANFH \| AOM \| COL11A3 \| MGC131516 \| SEDC	collagen, type II, alpha 1	-	HPRD,BioGRID	10085302
ENG	CD105 \| END \| FLJ41744 \| HHT1 \| ORW \| ORW1	endoglin	-	HPRD,BioGRID	9872992
MGP	GIG36 \| MGLAP \| NTI	matrix Gla protein	-	HPRD,BioGRID	11741887
NOG	SYM1 \| SYNS1	noggin	-	HPRD	10657699
SOSTDC1	CDA019 \| DKFZp564D206 \| ECTODIN \| USAG1	sclerostin domain containing 1	-	HPRD,BioGRID	14623234 \|15020244
TGFB1	CED \| DPD1 \| TGFB \| TGFbeta	transforming growth factor, beta 1	-	HPRD	11456401
TGFB2	MGC116892 \| TGF-beta2	transforming growth factor, beta 2	-	HPRD	9493905

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-142-5p	116	122	m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-17-5p/20/93.mr/106/519.d	93	99	1A	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-329	425	431	1A	hsa-miR-329^brain	AACACACCUGGUUAACCUCUUU
miR-369-3p	317	323	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	317	324	1A,m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-378	589	595	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-543	1115	1121	1A	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-543	1115	1121	1A	hsa-miR-543	AAACAUUCGCGGUGCACUUCU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.