Gene Page: SLC7A4
Summary ?
| GeneID | 6545 |
| Symbol | SLC7A4 |
| Synonyms | CAT-4|CAT4|HCAT3|VH |
| Description | solute carrier family 7 member 4 |
| Reference | MIM:603752|HGNC:HGNC:11062|Ensembl:ENSG00000099960|HPRD:04780|Vega:OTTHUMG00000150896 |
| Gene type | protein-coding |
| Map location | 22q11.21 |
| Pascal p-value | 0.301 |
| Sherlock p-value | 0.578 |
| Fetal beta | -0.96 |
| eGene | Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CNV:YES | Copy number variation studies | Manual curation | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.031 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SLC22A8 | 0.75 | 0.63 |
| OMD | 0.65 | 0.52 |
| SLC6A20 | 0.61 | 0.54 |
| OGN | 0.61 | 0.69 |
| SERPIND1 | 0.56 | 0.58 |
| SLC22A6 | 0.52 | 0.60 |
| CFH | 0.52 | 0.56 |
| CES1 | 0.51 | 0.52 |
| GJB2 | 0.50 | 0.50 |
| CPZ | 0.50 | 0.63 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| LZTS2 | -0.19 | -0.21 |
| PDE6B | -0.18 | -0.22 |
| NBR2 | -0.18 | -0.20 |
| KIAA0195 | -0.17 | -0.13 |
| SFRS16 | -0.17 | -0.25 |
| PLXNB1 | -0.17 | -0.21 |
| AC026468.2 | -0.17 | -0.26 |
| LIME1 | -0.17 | -0.15 |
| KCNH8 | -0.17 | -0.27 |
| SREBF1 | -0.16 | -0.16 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0015174 | basic amino acid transmembrane transporter activity | TAS | 9598310 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006520 | amino acid metabolic process | TAS | 9598310 | |
| GO:0006810 | transport | TAS | 9598310 | |
| GO:0006865 | amino acid transport | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0016020 | membrane | IEA | - | |
| GO:0016021 | integral to membrane | TAS | 9598310 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |
| SERVITJA LIVER HNF1A TARGETS UP | 135 | 96 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY LUMINAL MATURE UP | 116 | 65 | All SZGR 2.0 genes in this pathway |