Gene Page: BMPR1B

Summary ?
GeneID658
SymbolBMPR1B
SynonymsALK-6|ALK6|AMDD|BDA1D|BDA2|CDw293
Descriptionbone morphogenetic protein receptor type 1B
ReferenceMIM:603248|HGNC:HGNC:1077|Ensembl:ENSG00000138696|HPRD:04457|Vega:OTTHUMG00000130991
Gene typeprotein-coding
Map location4q22-q24
Pascal p-value0.004
Fetal beta-1.213
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
CV:PheWASPhenome-wide association studies (PheWAS)157 SNPs associated with schizophrenia 1
DMG:Montano_2016Genome-wide DNA methylation analysisThis dataset includes 172 replicated associations between CpGs with schizophrenia. 1
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 2.4469 

Section I. Genetics and epigenetics annotation

@CV:PheWAS

SNP IDChromosomePositionAllelePFunctionGeneUp/Down Distance
rs1002130340null1.669BMPR1Bnull

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg21746997495679381BMPR1B1.96E-4-0.0070.155DMG:Montano_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ATP5C10.880.87
SUCLG10.850.85
MYL12B0.850.85
ZNHIT30.850.85
GLRX30.840.86
PSMA60.830.83
TOMM220.830.83
MRPL150.830.81
COMMD70.830.84
PSMB30.830.83
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.26-0.65-0.63
AF347015.2-0.64-0.60
AF347015.15-0.62-0.58
AF347015.8-0.61-0.56
AF347015.18-0.60-0.59
MT-CYB-0.60-0.57
AF347015.33-0.58-0.56
MT-CO2-0.57-0.51
AF347015.27-0.57-0.56
FAM38A-0.56-0.55

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:0004872receptor activityIEA-
GO:0005025transforming growth factor beta receptor activity, type IIEA-
GO:0005524ATP bindingIDA12065756 
GO:0016740transferase activityIEA-
GO:0030145manganese ion bindingIEA-
GO:0046332SMAD bindingIDA12065756 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001550ovarian cumulus expansionISS-
GO:0001501skeletal system developmentIMP14523231 
GO:0001502cartilage condensationNAS14523231 
GO:0006468protein amino acid phosphorylationIDA12065756 
GO:0009953dorsal/ventral pattern formationIEA-
GO:0006954inflammatory responseIEA-
GO:0042698ovulation cycleISS-
GO:0030501positive regulation of bone mineralizationIMP18436533 
GO:0030509BMP signaling pathwayEXP15621726 
GO:0030509BMP signaling pathwayNAS10051328 
GO:0043010camera-type eye developmentIEA-
GO:0035108limb morphogenesisIMP14523231 
GO:0045669positive regulation of osteoblast differentiationIMP18436533 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043235receptor complexTASNeurotransmitter (GO term level: 4)14523231 
GO:0005886plasma membraneEXP17356069 
GO:0005887integral to plasma membraneIC14523231 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BMP2BMP2Abone morphogenetic protein 2Reconstituted ComplexBioGRID10712517 
BMP2BMP2Abone morphogenetic protein 2-HPRD9872992 
BMP4BMP2B | BMP2B1 | MCOPS6 | ZYMEbone morphogenetic protein 4-HPRD7811286 |8702914 
|11282024 
BMP4BMP2B | BMP2B1 | MCOPS6 | ZYMEbone morphogenetic protein 4Reconstituted ComplexBioGRID8006002 
BMP4BMP2B | BMP2B1 | MCOPS6 | ZYMEbone morphogenetic protein 4BMP4 interacts with BMPR1B (BR). This interaction was modeled on a demonstrated interaction between BMP4 from an unspecified species and BMPR1B from an unspecified species.BIND15775969 
BMP6VGR | VGR1bone morphogenetic protein 6-HPRD10504300 |11401330 
BMP7OP-1bone morphogenetic protein 7-HPRD8605097 
BMP7OP-1bone morphogenetic protein 7Reconstituted ComplexBioGRID8006002 
BMPR1A10q23del | ACVRLK3 | ALK3 | CD292bone morphogenetic protein receptor, type IA-HPRD,BioGRID10712517 
BMPR1BALK-6 | ALK6 | CDw293bone morphogenetic protein receptor, type IB-HPRD,BioGRID10712517 
BMPR2BMPR-II | BMPR3 | BMR2 | BRK-3 | FLJ41585 | FLJ76945 | PPH1 | T-ALKbone morphogenetic protein receptor, type II (serine/threonine kinase)-HPRD,BioGRID10712517 
GDF5BMP14 | CDMP1 | LAP4 | SYNS2growth differentiation factor 5Reconstituted ComplexBioGRID9525338 
GDF5BMP14 | CDMP1 | LAP4 | SYNS2growth differentiation factor 5-HPRD11282024 
GDF6BMP13 | CDMP2 | KFS | KFSL | MGC158100 | MGC158101 | SGM1growth differentiation factor 6-HPRD,BioGRID9525338 
GDF9-growth differentiation factor 9-HPRD12135884 
RANARA24 | Gsp1 | TC4RAN, member RAS oncogene familyBMPR1B interacts with RAN. This interaction was modeled on a demonstrated interaction between human BMPR1B and mouse RAN.BIND15761153 
SNX6MGC3157 | MSTP010 | TFAF2sorting nexin 6-HPRD,BioGRID11279102 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267161All SZGR 2.0 genes in this pathway
KEGG TGF BETA SIGNALING PATHWAY 8664All SZGR 2.0 genes in this pathway
PID BMP PATHWAY 4231All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY BMP 2315All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE DN 244147All SZGR 2.0 genes in this pathway
DOANE BREAST CANCER ESR1 UP 11272All SZGR 2.0 genes in this pathway
WANG RESPONSE TO ANDROGEN UP 2921All SZGR 2.0 genes in this pathway
WANG RESPONSE TO FORSKOLIN UP 2317All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER ADVANCED VS EARLY UP 175120All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367220All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781465All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
FINETTI BREAST CANCERS KINOME BLUE 2116All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 UP 295149All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B UP 172109All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY UP 250168All SZGR 2.0 genes in this pathway
SETLUR PROSTATE CANCER TMPRSS2 ERG FUSION UP 6748All SZGR 2.0 genes in this pathway
STAMBOLSKY RESPONSE TO VITAMIN D3 UP 8448All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN 157106All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP C 9260All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 UP 344215All SZGR 2.0 genes in this pathway
JUBAN TARGETS OF SPI1 AND FLI1 DN 9260All SZGR 2.0 genes in this pathway