Gene Page: BMPR1B

Summary
GeneID  658
Symbol  BMPR1B
Synonyms  ALK-6|ALK6|CDw293
Description  bone morphogenetic protein receptor, type IB
See related  HGNC:1077|MIM:603248|Ensembl:ENSG00000138696|HPRD:04457|
Locus tag  -
Gene type  protein-coding
Map location  4q22-q24
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 2.4469 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ATP5C10.880.87
SUCLG10.850.85
MYL12B0.850.85
ZNHIT30.850.85
GLRX30.840.86
PSMA60.830.83
TOMM220.830.83
MRPL150.830.81
COMMD70.830.84
PSMB30.830.83
Top 10 negatively co-expressed genes
AF347015.26-0.65-0.63
AF347015.2-0.64-0.60
AF347015.15-0.62-0.58
AF347015.8-0.61-0.56
AF347015.18-0.60-0.59
MT-CYB-0.60-0.57
AF347015.33-0.58-0.56
MT-CO2-0.57-0.51
AF347015.27-0.57-0.56
FAM38A-0.56-0.55
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:0004872receptor activityIEA-
GO:0005025transforming growth factor beta receptor activity, type IIEA-
GO:0005524ATP bindingIDA12065756 
GO:0016740transferase activityIEA-
GO:0030145manganese ion bindingIEA-
GO:0046332SMAD bindingIDA12065756 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001550ovarian cumulus expansionISS-
GO:0001501skeletal system developmentIMP14523231 
GO:0001502cartilage condensationNAS14523231 
GO:0006468protein amino acid phosphorylationIDA12065756 
GO:0009953dorsal/ventral pattern formationIEA-
GO:0006954inflammatory responseIEA-
GO:0042698ovulation cycleISS-
GO:0030501positive regulation of bone mineralizationIMP18436533 
GO:0030509BMP signaling pathwayEXP15621726 
GO:0030509BMP signaling pathwayNAS10051328 
GO:0043010camera-type eye developmentIEA-
GO:0035108limb morphogenesisIMP14523231 
GO:0045669positive regulation of osteoblast differentiationIMP18436533 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043235receptor complexTASNeurotransmitter (GO term level: 4)14523231 
GO:0005886plasma membraneEXP17356069 
GO:0005887integral to plasma membraneIC14523231 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BMP2BMP2Abone morphogenetic protein 2Reconstituted ComplexBioGRID10712517 
-HPRD9872992 
BMP4BMP2B | BMP2B1 | MCOPS6 | ZYMEbone morphogenetic protein 4-HPRD7811286 |8702914 
|11282024 
Reconstituted ComplexBioGRID8006002 
BMP4 interacts with BMPR1B (BR). This interaction was modeled on a demonstrated interaction between BMP4 from an unspecified species and BMPR1B from an unspecified species.BIND15775969 
BMP6VGR | VGR1bone morphogenetic protein 6-HPRD10504300 |11401330 
BMP7OP-1bone morphogenetic protein 7-HPRD8605097 
Reconstituted ComplexBioGRID8006002 
BMPR1A10q23del | ACVRLK3 | ALK3 | CD292bone morphogenetic protein receptor, type IA-HPRD,BioGRID10712517 
BMPR1BALK-6 | ALK6 | CDw293bone morphogenetic protein receptor, type IB-HPRD,BioGRID10712517 
BMPR2BMPR-II | BMPR3 | BMR2 | BRK-3 | FLJ41585 | FLJ76945 | PPH1 | T-ALKbone morphogenetic protein receptor, type II (serine/threonine kinase)-HPRD,BioGRID10712517 
GDF5BMP14 | CDMP1 | LAP4 | SYNS2growth differentiation factor 5Reconstituted ComplexBioGRID9525338 
-HPRD11282024 
GDF6BMP13 | CDMP2 | KFS | KFSL | MGC158100 | MGC158101 | SGM1growth differentiation factor 6-HPRD,BioGRID9525338 
GDF9-growth differentiation factor 9-HPRD12135884 
RANARA24 | Gsp1 | TC4RAN, member RAS oncogene familyBMPR1B interacts with RAN. This interaction was modeled on a demonstrated interaction between human BMPR1B and mouse RAN.BIND15761153 
SNX6MGC3157 | MSTP010 | TFAF2sorting nexin 6-HPRD,BioGRID11279102 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_TGF_BETA_SIGNALING_PATHWAY 8664All SZGR genes in this pathway
PID_BMP_PATHWAY 4231All SZGR genes in this pathway
REACTOME_SIGNALING_BY_BMP 2315All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_DN 244147All SZGR genes in this pathway
DOANE_BREAST_CANCER_ESR1_UP 11272All SZGR genes in this pathway
WANG_RESPONSE_TO_ANDROGEN_UP 2921All SZGR genes in this pathway
WANG_RESPONSE_TO_FORSKOLIN_UP 2317All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_ADVANCED_VS_EARLY_UP 175120All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_DN 367220All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
FINETTI_BREAST_CANCERS_KINOME_BLUE 2116All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP 295149All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_UP 172109All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_UP 250168All SZGR genes in this pathway
SETLUR_PROSTATE_CANCER_TMPRSS2_ERG_FUSION_UP 6748All SZGR genes in this pathway
STAMBOLSKY_RESPONSE_TO_VITAMIN_D3_UP 8448All SZGR genes in this pathway
PANGAS_TUMOR_SUPPRESSION_BY_SMAD1_AND_SMAD5_DN 157106All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_C 9260All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_UP 344215All SZGR genes in this pathway
JUBAN_TARGETS_OF_SPI1_AND_FLI1_DN 9260All SZGR genes in this pathway


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