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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: BMPR2

Summary

GeneID

659

Symbol

BMPR2

Synonyms

BMPR-II|BMPR3|BMR2|BRK-3|FLJ41585|FLJ76945|PPH1|T-ALK

Description

bone morphogenetic protein receptor, type II (serine/threonine kinase)

Locus tag

Gene type

protein-coding

Map location

2q33-q34

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.1099

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

C1orf9

0.89

0.91

TOPORS

0.89

SMURF2

0.89

0.90

USP47

0.89

0.90

ADAM17

0.88

0.90

WRN

0.88

0.91

C14orf135

0.88

0.90

RBL2

0.88

0.90

DENND4C

0.88

0.91

CXorf38

0.88

0.87

Top 10 negatively co-expressed genes

IFI27

-0.65

-0.75

MT-CO2

-0.65

-0.74

AF347015.31

-0.64

-0.73

FXYD1

-0.63

-0.73

AF347015.27

-0.63

-0.71

CA4

-0.63

-0.69

MYL3

-0.63

-0.73

AF347015.33

-0.61

-0.70

AF347015.21

-0.61

-0.74

CXCL14

-0.60

-0.71

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0000287

magnesium ion binding

IEA

GO:0005024

transforming growth factor beta receptor activity

IEA

GO:0004872

receptor activity

IEA

GO:0005515

protein binding

IPI

15188402

GO:0005524

ATP binding

IEA

GO:0004672

protein kinase activity

IEA

GO:0004674

protein serine/threonine kinase activity

IEA

GO:0016740

transferase activity

IEA

GO:0030145

manganese ion binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0001707

mesoderm formation

IEA

GO:0001707

mesoderm formation

ISS

GO:0003085

negative regulation of systemic arterial blood pressure

IMP

18364108

GO:0007178

transmembrane receptor protein serine/threonine kinase signaling pathway

IEA

GO:0006468

protein amino acid phosphorylation

IEA

GO:0006366

transcription from RNA polymerase II promoter

IMP

12045205

GO:0009952

anterior/posterior pattern formation

IEA

GO:0009952

anterior/posterior pattern formation

ISS

GO:0048010

vascular endothelial growth factor receptor signaling pathway

ISS

GO:0014916

regulation of lung blood pressure

IMP

18364108

GO:0014916

regulation of lung blood pressure

ISS

GO:0042127

regulation of cell proliferation

IMP

11502704

GO:0030501

positive regulation of bone mineralization

IMP

18436533

GO:0030509

BMP signaling pathway

EXP

15621726

GO:0030509

BMP signaling pathway

IDA

18436533

GO:0030509

BMP signaling pathway

IMP

12045205

GO:0030509

BMP signaling pathway

ISS

GO:0048286

alveolus development

ISS

GO:0045906

negative regulation of vasoconstriction

ISS

GO:0045669

positive regulation of osteoblast differentiation

IMP

18436533

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0016020

membrane

IEA

GO:0009986

cell surface

IEA

GO:0009986

cell surface

ISS

GO:0005886

plasma membrane

EXP

17356069

GO:0005887

integral to plasma membrane

IDA

12045205

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACVR1	ACTRI \| ACVR1A \| ACVRLK2 \| ALK2 \| FOP \| SKR1 \| TSRI	activin A receptor, type I	Affinity Capture-Western Two-hybrid	BioGRID	7791754
ACVR1B	ACTRIB \| ACVRLK4 \| ALK4 \| SKR2	activin A receptor, type IB	Two-hybrid	BioGRID	7791754
BMP2	BMP2A	bone morphogenetic protein 2	-	HPRD,BioGRID	10880444
BMP4	BMP2B \| BMP2B1 \| MCOPS6 \| ZYME	bone morphogenetic protein 4	-	HPRD,BioGRID	7644468 \|8702914
BMP6	VGR \| VGR1	bone morphogenetic protein 6	Affinity Capture-Western	BioGRID	10504300
BMP6	VGR \| VGR1	bone morphogenetic protein 6	-	HPRD	11401330
BMP7	OP-1	bone morphogenetic protein 7	-	HPRD,BioGRID	7791754
BMPR1A	10q23del \| ACVRLK3 \| ALK3 \| CD292	bone morphogenetic protein receptor, type IA	-	HPRD,BioGRID	10712517
BMPR1B	ALK-6 \| ALK6 \| CDw293	bone morphogenetic protein receptor, type IB	-	HPRD,BioGRID	10712517
BMPR2	BMPR-II \| BMPR3 \| BMR2 \| BRK-3 \| FLJ41585 \| FLJ76945 \| PPH1 \| T-ALK	bone morphogenetic protein receptor, type II (serine/threonine kinase)	-	HPRD,BioGRID	10712517
CES3	ES31 \| FLJ21736	carboxylesterase 3	Affinity Capture-MS	BioGRID	15188402
CRYAB	CRYA2 \| CTPP2 \| HSPB5	crystallin, alpha B	Affinity Capture-MS	BioGRID	15188402
DYNLT1	CW-1 \| MGC111571 \| TCTEL1 \| tctex-1	dynein, light chain, Tctex-type 1	-	HPRD	14583445
FRS3	FRS2B \| FRS2beta \| MGC17167 \| SNT-2 \| SNT2	fibroblast growth factor receptor substrate 3	Affinity Capture-MS	BioGRID	15188402
GCGR	GGR \| MGC138246	glucagon receptor	Affinity Capture-MS	BioGRID	15188402
GDF5	BMP14 \| CDMP1 \| LAP4 \| SYNS2	growth differentiation factor 5	-	HPRD,BioGRID	9525338
GDF6	BMP13 \| CDMP2 \| KFS \| KFSL \| MGC158100 \| MGC158101 \| SGM1	growth differentiation factor 6	-	HPRD,BioGRID	9525338
GDF9	-	growth differentiation factor 9	-	HPRD,BioGRID	12135884
LIMK1	LIMK	LIM domain kinase 1	-	HPRD,BioGRID	12963706
LSM10	MGC15749 \| MST074 \| MSTP074	LSM10, U7 small nuclear RNA associated	-	HPRD	15188402
NOL5A	NOP56	nucleolar protein 5A (56kDa with KKE/D repeat)	-	HPRD	15188402
PDZRN3	LNX3 \| SEMACAP3	PDZ domain containing ring finger 3	-	HPRD	15188402
TGFBR1	AAT5 \| ACVRLK4 \| ALK-5 \| ALK5 \| LDS1A \| LDS2A \| SKR4 \| TGFR-1	transforming growth factor, beta receptor 1	Two-hybrid	BioGRID	7791754
TRPC1	HTRP-1 \| MGC133334 \| MGC133335 \| TRP1	transient receptor potential cation channel, subfamily C, member 1	-	HPRD	15188402
TSR1	FLJ10534 \| KIAA1401 \| MGC131829	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)	Two-hybrid	BioGRID	7791754
TWF1	A6 \| MGC23788 \| MGC41876 \| PTK9	twinfilin, actin-binding protein, homolog 1 (Drosophila)	-	HPRD	15188402

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-125/351	6326	6332	m8	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	6326	6332	m8	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-129-5p	310	316	m8	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
miR-129-5p	310	316	m8	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-130/301	204	210	m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-135	5613	5619	m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	5613	5619	m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-136	692	698	1A	hsa-miR-136	ACUCCAUUUGUUUUGAUGAUGGA
miR-137	6380	6386	m8	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-153	148	154	m8	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-17-5p/20/93.mr/106/519.d	206	212	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-181	503	509	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-186	7732	7738	1A	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-19	203	209	m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	203	209	m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-25/32/92/363/367	508	515	1A,m8	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-329	7419	7425	m8	hsa-miR-329^brain	AACACACCUGGUUAACCUCUUU
miR-33	5737	5743	1A	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
miR-33	5737	5743	1A	hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-330	7657	7664	1A,m8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-342	7546	7552	m8	hsa-miR-342^brain	UCUCACACAGAAAUCGCACCCGUC
miR-361	327	333	1A	hsa-miR-361^brain	UUAUCAGAAUCUCCAGGGGUAC
miR-369-3p	7582	7588	m8	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-376	7601	7607	1A	hsa-miR-376a	AUCAUAGAGGAAAAUCCACGU
miR-376	7601	7607	1A	hsa-miR-376b	AUCAUAGAGGAAAAUCCAUGUU
miR-384	2473	2479	1A	hsa-miR-384	AUUCCUAGAAAUUGUUCAUA
miR-450	310	316	1A	hsa-miR-450	UUUUUGCGAUGUGUUCCUAAUA
miR-494	6432	6439	1A,m8	hsa-miR-494^brain	UGAAACAUACACGGGAAACCUCUU
miR-544	50	56	m8	hsa-miR-544	AUUCUGCAUUUUUAGCAAGU
miR-544	50	56	m8	hsa-miR-544	AUUCUGCAUUUUUAGCAAGU
miR-7	572	578	1A	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG
miR-99/100	7403	7409	1A	hsa-miR-99a^brain	AACCCGUAGAUCCGAUCUUGUG
				hsa-miR-100^brain	AACCCGUAGAUCCGAACUUGUG
				hsa-miR-99b^brain	CACCCGUAGAACCGACCUUGCG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.