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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: SNCB

Summary

GeneID

6620

Symbol

SNCB

Synonyms

Description

synuclein, beta

Locus tag

Gene type

protein-coding

Map location

5q35

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.0276

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 2

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

XPR1

0.95

0.93

NFIB

0.95

0.94

PELI2

0.94

0.85

ITSN1

0.92

0.91

USP6NL

0.92

TBR1

0.91

0.87

AFF3

0.90

0.94

NPR3

0.90

0.89

RBPSUH

0.90

0.82

MYO5B

0.89

0.86

Top 10 negatively co-expressed genes

SERPINB6

-0.57

-0.76

TNFSF12

-0.53

-0.62

SLC9A3R2

-0.51

-0.48

HDDC2

-0.51

-0.55

LHPP

-0.51

-0.60

SLC16A11

-0.51

-0.64

C19orf66

-0.51

-0.39

TMEM54

-0.50

-0.56

AC007405.8

-0.50

-0.65

BAMBI

-0.50

-0.58

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004859

phospholipase inhibitor activity

TAS

9806846

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0042417

dopamine metabolic process

IEA

Neurotransmitter, dopamine (GO term level: 8)

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0019717

synaptosome

IEA

Synap, Brain (GO term level: 7)

GO:0005737

cytoplasm

IEA

GO:0005739

mitochondrion

IEA

Interactions

Shown by Network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
APP	AAA \| ABETA \| ABPP \| AD1 \| APPI \| CTFgamma \| CVAP \| PN2	amyloid beta (A4) precursor protein	-	HPRD,BioGRID	9163350
GRK1	GPRK1 \| RHOK \| RK	G protein-coupled receptor kinase 1	Biochemical Activity	BioGRID	10852916
GRK5	GPRK5	G protein-coupled receptor kinase 5	Biochemical Activity	BioGRID	10852916
GRK6	FLJ32135 \| GPRK6	G protein-coupled receptor kinase 6	Biochemical Activity	BioGRID	10852916
SEPT4	ARTS \| BRADEION \| CE5B3 \| H5 \| MART \| PNUTL2 \| SEP4 \| hCDCREL-2 \| hucep-7	septin 4	-	HPRD	12695511
SNCA	MGC110988 \| NACP \| PARK1 \| PARK4 \| PD1	synuclein, alpha (non A4 component of amyloid precursor)	-	HPRD,BioGRID	11683992

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-136	510	516	1A	hsa-miR-136	ACUCCAUUUGUUUUGAUGAUGGA
miR-138	18	25	1A,m8	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-149	61	67	m8	hsa-miR-149^brain	UCUGGCUCCGUGUCUUCACUCC
miR-149	61	67	m8	hsa-miR-149^brain	UCUGGCUCCGUGUCUUCACUCC
miR-183	439	445	m8	hsa-miR-183	UAUGGCACUGGUAGAAUUCACUG
miR-218	25	31	1A	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-221/222	273	280	1A,m8	hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
miR-221/222	273	280	1A,m8	hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
miR-326	57	63	m8	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
miR-376c	284	290	m8	hsa-miR-376c	AACAUAGAGGAAAUUCCACG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.