Gene Page

Gene Page: SPARC

Summary

GeneID

6678

Symbol

SPARC

Synonyms

Description

secreted protein, acidic, cysteine-rich (osteonectin)

Locus tag

Gene type

protein-coding

Map location

5q31.3-q32

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.0032

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.00459

GSMA_IIE

genome scan meta-analysis (European-ancestry samples)

Psr: 0.01718

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005507

copper ion binding

IEA

GO:0005509

calcium ion binding

TAS

7034958

GO:0005518

collagen binding

TAS

7034958

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0001503

ossification

TAS

7034958

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

NAS

15609325

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005576

extracellular region

EXP

1737102

GO:0005576

extracellular region

NAS

14718574

GO:0005604

basement membrane

IEA

GO:0031093

platelet alpha granule lumen

EXP

1737102

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
COL13A1	COLXIIIA1 \| FLJ42485	collagen, type XIII, alpha 1	-	HPRD,BioGRID	11956183
COL1A1	OI4	collagen, type I, alpha 1	-	HPRD	7034958
COL1A1	OI4	collagen, type I, alpha 1	Reconstituted Complex	BioGRID	2745554
COL1A2	OI4	collagen, type I, alpha 2	-	HPRD	7034958
COL2A1	ANFH \| AOM \| COL11A3 \| MGC131516 \| SEDC	collagen, type II, alpha 1	-	HPRD	2745554
COL3A1	EDS4A \| FLJ34534	collagen, type III, alpha 1	Reconstituted Complex	BioGRID	2745554
COL5A1	-	collagen, type V, alpha 1	Reconstituted Complex	BioGRID	2745554
HSPG2	PLC \| PRCAN \| SJA \| SJS \| SJS1	heparan sulfate proteoglycan 2	-	HPRD	2745554
PDGFB	FLJ12858 \| PDGF2 \| SIS \| SSV \| c-sis	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	Reconstituted Complex	BioGRID	1311092
PLAT	DKFZp686I03148 \| T-PA \| TPA	plasminogen activator, tissue	-	HPRD	2745554
PLG	DKFZp779M0222	plasminogen	-	HPRD,BioGRID	2745554 \|7982919
SDC2	HSPG \| HSPG1 \| SYND2	syndecan 2	-	HPRD	2745554
SPARC	ON	secreted protein, acidic, cysteine-rich (osteonectin)	-	HPRD	9233787
TGFB1	CED \| DPD1 \| TGFB \| TGFbeta	transforming growth factor, beta 1	-	HPRD	15034927
TGM2	G-ALPHA-h \| GNAH \| TG2 \| TGC	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	-	HPRD	7730416
THBS1	THBS \| TSP \| TSP1	thrombospondin 1	-	HPRD	2745554 \|3402455
VEGFA	MGC70609 \| VEGF \| VEGF-A \| VPF	vascular endothelial growth factor A	-	HPRD,BioGRID	9792673

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-203.1	1033	1039	1A	hsa-miR-203	UGAAAUGUUUAGGACCACUAG
miR-29	104	110	1A	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
				hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-339	1301	1307	1A	hsa-miR-339	UCCCUGUCCUCCAGGAGCUCA
miR-433-3p	1037	1043	1A	hsa-miR-433^brain	AUCAUGAUGGGCUCCUCGGUGU
miR-452	1241	1248	1A,m8	hsa-miR-452	UGUUUGCAGAGGAAACUGAGAC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.