Gene Page: SPTA1

Summary
GeneID  6708
Symbol  SPTA1
Synonyms  EL2|SPTA
Description  spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
See related  HGNC:11272|MIM:182860|Ensembl:ENSG00000163554|HPRD:01685|
Locus tag  -
Gene type  protein-coding
Map location  1q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TCEB20.910.90
C22orf320.900.90
NDUFA110.890.84
EIF3K0.890.82
ATP5L0.890.87
RPS210.880.85
PFDN50.870.88
MRPL530.870.85
FAM96B0.870.85
AC009171.10.870.88
Top 10 negatively co-expressed genes
COBLL1-0.53-0.63
SYNM-0.53-0.68
Z83840.4-0.51-0.66
FLT1-0.51-0.64
MYH9-0.51-0.53
RRBP1-0.50-0.63
PTPRB-0.50-0.60
TRIM44-0.50-0.60
EPB41L2-0.49-0.64
PK4P-0.48-0.60
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIPI9593709 |12820899 
GO:0005200structural constituent of cytoskeletonTAS1634521 
GO:0051015actin filament bindingTAS1634521 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008360regulation of cell shapeIEA-
GO:0007015actin filament organizationTAS1634521 
GO:0051016barbed-end actin filament cappingIEA-
GO:0030097hemopoiesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005856cytoskeletonIEA-
GO:0005737cytoplasmIEA-
GO:0008091spectrinTAS1634521 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinaseAffinity Capture-Western
Reconstituted Complex		BioGRID9593709 
ADD1ADDA | MGC3339 | MGC44427adducin 1 (alpha)-HPRD,BioGRID3600811 |8626479 
ANK1ANK | SPH1 | SPH2ankyrin 1, erythrocyticReconstituted ComplexBioGRID2971657 
ERCC4RAD1 | XPFexcision repair cross-complementing rodent repair deficiency, complementation group 4Affinity Capture-WesternBioGRID12571280 
EZRCVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2ezrinAffinity Capture-MSBioGRID14625392 
FANCAFA | FA-H | FA1 | FAA | FACA | FAH | FANCH | MGC75158Fanconi anemia, complementation group AAffinity Capture-WesternBioGRID12571280 
FANCCFA3 | FAC | FACC | FLJ14675Fanconi anemia, complementation group C-HPRD10551855 
PLEC1EBS1 | EBSO | HD1 | PCN | PLEC1b | PLTNplectin 1, intermediate filament binding protein 500kDa-HPRD,BioGRID3027087 
SLC9A2NHE2solute carrier family 9 (sodium/hydrogen exchanger), member 2-HPRD,BioGRID10187839 
SPTBHSpTB1spectrin, beta, erythrocytic-HPRD,BioGRID1634521 
 


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