Gene Page: STAT5B

Summary
GeneID  6777
Symbol  STAT5B
Synonyms  STAT5
Description  signal transducer and activator of transcription 5B
See related  HGNC:11367|MIM:604260|Ensembl:ENSG00000173757|HPRD:05037|
Locus tag  -
Gene type  protein-coding
Map location  17q11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.2058 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SHISA40.870.85
RHBDL10.850.86
CA110.840.82
C5orf320.830.82
EGFL70.830.79
KLHDC90.830.80
MARCH20.830.72
GCAT0.820.78
C12orf620.820.78
CISD30.820.79
Top 10 negatively co-expressed genes
THOC2-0.57-0.64
PHF14-0.55-0.63
ZNF326-0.55-0.59
TOP2B-0.55-0.55
ZBTB10-0.55-0.58
KIAA1949-0.55-0.56
SFRS12-0.54-0.59
FNBP1L-0.54-0.55
HNRNPU-0.54-0.57
TUBB2B-0.54-0.59
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004871signal transducer activityIEA-
GO:0003700transcription factor activityTAS8631883 
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIPI9989503 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001553luteinizationIEA-
GO:0001779natural killer cell differentiationIEA-
GO:0007259JAK-STAT cascadeTAS8631883 
GO:0007165signal transductionIEA-
GO:0008284positive regulation of cell proliferationIEA-
GO:0019915sequestering of lipidIEA-
GO:0007595lactationIEA-
GO:0007565female pregnancyIEA-
GO:0042448progesterone metabolic processIEA-
GO:0043066negative regulation of apoptosisIEA-
GO:0030155regulation of cell adhesionIEA-
GO:0042104positive regulation of activated T cell proliferationIEA-
GO:0040018positive regulation of multicellular organism growthIEA-
GO:0030856regulation of epithelial cell differentiationIEA-
GO:0019218regulation of steroid metabolic processIEA-
GO:0019221cytokine-mediated signaling pathwayIEA-
GO:0043029T cell homeostasisIEA-
GO:0045579positive regulation of B cell differentiationIEA-
GO:0045647negative regulation of erythrocyte differentiationIEA-
GO:0045885positive regulation of survival gene product expressionIEA-
GO:0045931positive regulation of mitotic cell cycleIEA-
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
GO:0050729positive regulation of inflammatory responseIEA-
GO:0045086positive regulation of interleukin-2 biosynthetic processIEA-
GO:0046543development of secondary female sexual characteristicsIEA-
GO:0046544development of secondary male sexual characteristicsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CCR5CC-CKR-5 | CCCKR5 | CD195 | CKR-5 | CKR5 | CMKBR5chemokine (C-C motif) receptor 5Affinity Capture-WesternBioGRID11350939 
CD247CD3-ZETA | CD3H | CD3Q | CD3Z | T3Z | TCRZCD247 molecule-HPRD,BioGRID9880255 
CENPJBM032 | CPAP | LAP | LIP1 | MCPH6 | MGC131581 | MGC131582 | MGC142222 | MGC142224centromere protein J-HPRD12198240 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD,BioGRID10558875 
ELP2FLJ10879 | SHINC-2 | STATIP1 | StIPelongation protein 2 homolog (S. cerevisiae)-HPRD,BioGRID10954736 
GHRGHBPgrowth hormone receptor-HPRD,BioGRID8923468 
IL2RACD25 | IDDM10 | IL2R | TCGFRinterleukin 2 receptor, alpha-HPRD10602027 
IL2RBCD122 | P70-75interleukin 2 receptor, beta-HPRD,BioGRID10602027 
JAK1JAK1A | JAK1B | JTK3Janus kinase 1 (a protein tyrosine kinase)Affinity Capture-Western
Two-hybrid		BioGRID9047382 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)Affinity Capture-Western
Two-hybrid		BioGRID9047382 |9575217 
JAK3JAK-3 | JAK3_HUMAN | JAKL | L-JAK | LJAKJanus kinase 3 (a protein tyrosine kinase, leukocyte)Two-hybridBioGRID9047382 
MAPK1ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapkmitogen-activated protein kinase 1-HPRD10996427 
NCOR2CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1nuclear receptor co-repressor 2-HPRD11726519 
NMI-N-myc (and STAT) interactorNmi interacts with Stat5bBIND9989503 
-HPRD,BioGRID9989503 
NR3C1GCCR | GCR | GR | GRLnuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)-HPRD,BioGRID8878484 |9528750 
|11158330 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11Biochemical Activity
Reconstituted Complex		BioGRID10617656 
PTPN6HCP | HCPH | HPTP1C | PTP-1C | SH-PTP1 | SHP-1 | SHP-1L | SHP1protein tyrosine phosphatase, non-receptor type 6-HPRD,BioGRID9211920 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1Affinity Capture-WesternBioGRID10996427 
STAT5AMGF | STAT5signal transducer and activator of transcription 5A-HPRD9528750 
STAT5BSTAT5signal transducer and activator of transcription 5BPhosphorylated STAT5b interacts with phosphorylated STAT5b to form a dimer.BIND10594041 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-129-5p311317m8hsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-141/200a15431549m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-19218224m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-194253325391Ahsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-21712231229m8hsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-231041111A,m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-3231031101A,m8hsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-3633093151Ahsa-miR-363AUUGCACGGUAUCCAUCUGUAA
miR-4503113171Ahsa-miR-450UUUUUGCGAUGUGUUCCUAAUA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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