Gene Page: TCP11
Summary ?
| GeneID | 6954 |
| Symbol | TCP11 |
| Synonyms | D6S230E|FPPR |
| Description | t-complex 11 |
| Reference | MIM:186982|HGNC:HGNC:11658|Ensembl:ENSG00000124678|HPRD:01749|Vega:OTTHUMG00000014560 |
| Gene type | protein-coding |
| Map location | 6p21.31 |
| Pascal p-value | 0.019 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.033 | |
| GSMA_IIE | Genome scan meta-analysis (European-ancestry samples) | Psr: 0.04433 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SUV420H1 | 0.95 | 0.95 |
| BIVM | 0.94 | 0.95 |
| AC092490.2 | 0.94 | 0.93 |
| PDIK1L | 0.93 | 0.95 |
| ZNF599 | 0.93 | 0.90 |
| ZNF45 | 0.93 | 0.94 |
| ADNP | 0.93 | 0.95 |
| C6orf174 | 0.93 | 0.94 |
| ZFP28 | 0.93 | 0.95 |
| TGS1 | 0.93 | 0.95 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| HLA-F | -0.75 | -0.80 |
| AIFM3 | -0.75 | -0.79 |
| TSC22D4 | -0.73 | -0.81 |
| ALDOC | -0.73 | -0.73 |
| AF347015.31 | -0.73 | -0.88 |
| AF347015.27 | -0.72 | -0.87 |
| S100B | -0.72 | -0.83 |
| MT-CO2 | -0.72 | -0.90 |
| FBXO2 | -0.72 | -0.68 |
| CLU | -0.72 | -0.73 |
Section III. Gene Ontology annotation
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0007283 | spermatogenesis | IEA | - | |
| GO:0007275 | multicellular organismal development | IEA | - | |
| GO:0030154 | cell differentiation | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0016020 | membrane | IEA | - | |
| GO:0016021 | integral to membrane | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| MCCLUNG COCAIN REWARD 4WK | 75 | 47 | All SZGR 2.0 genes in this pathway |
| WEBER METHYLATED HCP IN FIBROBLAST DN | 42 | 22 | All SZGR 2.0 genes in this pathway |
| WEBER METHYLATED HCP IN SPERM UP | 20 | 13 | All SZGR 2.0 genes in this pathway |
| MEISSNER BRAIN HCP WITH H3K4ME2 AND H3K27ME3 | 59 | 35 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 6 DN | 38 | 19 | All SZGR 2.0 genes in this pathway |
| DELACROIX RAR BOUND ES | 462 | 273 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |