Gene Page: TFE3

Summary
GeneID  7030
Symbol  TFE3
Synonyms  RCCP2|TFEA|bHLHe33
Description  transcription factor binding to IGHM enhancer 3
See related  HGNC:11752|MIM:314310|Ensembl:ENSG00000068323|HPRD:02439|
Locus tag  -
Gene type  protein-coding
Map location  Xp11.22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0587 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SF3B10.940.95
BRD80.930.93
ZNF6150.920.93
GPBP10.920.92
C17orf800.910.94
C10orf1370.910.93
UHRF20.910.94
KIAA09070.910.92
ZC3H140.910.92
CDC70.910.92
Top 10 negatively co-expressed genes
AF347015.31-0.80-0.87
MT-CO2-0.80-0.86
MT-CYB-0.78-0.84
AF347015.27-0.78-0.85
AF347015.8-0.77-0.85
AF347015.33-0.77-0.83
AF347015.2-0.75-0.84
AF347015.15-0.75-0.84
HIGD1B-0.75-0.84
IFI27-0.74-0.84
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003700transcription factor activityNAS1685140 
GO:0005515protein bindingIPI17353931 
GO:0005524ATP bindingIEA-
GO:0004812aminoacyl-tRNA ligase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006418tRNA aminoacylation for protein translationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACLYACL | ATPCL | CLATPATP citrate lyaseAffinity Capture-MSBioGRID17353931 
AKR1B1ADR | ALDR1 | ALR2 | AR | MGC1804aldo-keto reductase family 1, member B1 (aldose reductase)Affinity Capture-MSBioGRID17353931 
CLTCCHC | CHC17 | CLH-17 | CLTCL2 | Hc | KIAA0034clathrin, heavy chain (Hc)Affinity Capture-MSBioGRID17353931 
CUL2MGC131970cullin 2Affinity Capture-MSBioGRID17353931 
E2F3DKFZp686C18211 | E2F-3 | KIAA0075 | MGC104598E2F transcription factor 3-HPRD,BioGRID12748276 
EIF3AEIF3 | EIF3S10 | KIAA0139 | P167 | TIF32 | eIF3-p170 | eIF3-theta | p180 | p185eukaryotic translation initiation factor 3, subunit AAffinity Capture-MSBioGRID17353931 
EPRSDKFZp313B047 | EARS | GLUPRORS | PARS | PIG32 | QARS | QPRSglutamyl-prolyl-tRNA synthetaseAffinity Capture-MSBioGRID17353931 
MITFMI | WS2A | bHLHe32microphthalmia-associated transcription factor-HPRD,BioGRID11930005 
NEDD8FLJ43224 | MGC104393 | MGC125896 | MGC125897 | Nedd-8neural precursor cell expressed, developmentally down-regulated 8Affinity Capture-MSBioGRID17353931 
PFASFGAMS | FGARAT | KIAA0361 | PURLphosphoribosylformylglycinamidine synthaseAffinity Capture-MSBioGRID17353931 
PHB2BAP | BCAP37 | Bap37 | MGC117268 | PNAS-141 | REA | p22prohibitin 2Affinity Capture-MSBioGRID17353931 
RPA3REPA3replication protein A3, 14kDaAffinity Capture-MSBioGRID17353931 
RPL38-ribosomal protein L38Affinity Capture-MSBioGRID17353931 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3-HPRD10557285 |10973944 
|12551947 
Reconstituted ComplexBioGRID10557285 |12551947 
SMAD4DPC4 | JIP | MADH4SMAD family member 4-HPRD,BioGRID10557285 
SMARCE1BAF57SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1Reconstituted ComplexBioGRID11018012 
TFE3RCCP2 | TFEA | bHLHe33transcription factor binding to IGHM enhancer 3-HPRD,BioGRID2044953 
TFEBAlphaTFEB | TCFEB | bHLHe35transcription factor EB-HPRD,BioGRID9806910 
TFECTCFEC | TFECL | bHLHe34transcription factor EC-HPRD,BioGRID8336698 |11467950 
TRIM28FLJ29029 | KAP1 | RNF96 | TF1B | TIF1Btripartite motif-containing 28Affinity Capture-MSBioGRID17353931 
VARSG7A | VARS1 | VARS2valyl-tRNA synthetaseAffinity Capture-MSBioGRID17353931 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/2067477531Ahsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-32013201326m8hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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