Gene Page: TGFBR1

Summary
GeneID  7046
Symbol  TGFBR1
Synonyms  AAT5|ACVRLK4|ALK-5|ALK5|LDS1A|LDS2A|SKR4|TGFR-1
Description  transforming growth factor, beta receptor 1
See related  HGNC:11772|MIM:190181|Ensembl:ENSG00000106799|HPRD:01822|
Locus tag  -
Gene type  protein-coding
Map location  9q22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 8.9081 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
EXOC3L0.790.75
PTP4A30.740.73
RGL20.740.71
KRTCAP30.730.51
NKD20.730.73
RARA0.730.72
GALK10.730.66
CCDC1570.720.80
NNAT0.710.75
AC005544.10.710.67
Top 10 negatively co-expressed genes
AF347015.27-0.49-0.67
AF347015.31-0.49-0.66
MT-CO2-0.49-0.66
MT-CYB-0.47-0.65
AF347015.33-0.47-0.63
AF347015.8-0.46-0.66
AF347015.15-0.45-0.64
AF347015.2-0.44-0.63
COX4I2-0.44-0.58
AF347015.21-0.43-0.67
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:0005024transforming growth factor beta receptor activityIEA-
GO:0004872receptor activityIEA-
GO:0005114type II transforming growth factor beta receptor bindingIDA11157754 
GO:0005025transforming growth factor beta receptor activity, type ITAS8242743 
GO:0005524ATP bindingIDA12065756 
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
GO:0030145manganese ion bindingIEA-
GO:0046332SMAD bindingIDA12065756 
GO:0050431transforming growth factor beta bindingIDA14633705 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0048663neuron fate commitmentIEAneuron (GO term level: 9)-
GO:0001701in utero embryonic developmentIEA-
GO:0001822kidney developmentIEA-
GO:0007181transforming growth factor beta receptor complex assemblyTAS8242743 
GO:0007178transmembrane receptor protein serine/threonine kinase signaling pathwayIEA-
GO:0006468protein amino acid phosphorylationIDA12065756 
GO:0006468protein amino acid phosphorylationIEA-
GO:0009952anterior/posterior pattern formationIEA-
GO:0007165signal transductionIDA14633705 
GO:0008284positive regulation of cell proliferationIMP14633705 
GO:0008354germ cell migrationIEA-
GO:0009790embryonic developmentIEA-
GO:0007507heart developmentIEA-
GO:0043066negative regulation of apoptosisIEA-
GO:0060037pharyngeal system developmentIEA-
GO:0060017parathyroid gland developmentIEA-
GO:0030199collagen fibril organizationIEA-
GO:0048538thymus developmentIEA-
GO:0048705skeletal system morphogenesisIEA-
GO:0045449regulation of transcriptionIDA14517293 
GO:0045449regulation of transcriptionIMP15702480 
GO:0048844artery morphogenesisIEA-
GO:0060021palate developmentIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043235receptor complexIDANeurotransmitter (GO term level: 4)8774881 
GO:0016020membraneIEA-
GO:0005886plasma membraneEXP9865696 |11100470 
GO:0005887integral to plasma membraneTAS8242743 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AP2B1ADTB2 | AP105B | AP2-BETA | CLAPB1 | DKFZp781K0743adaptor-related protein complex 2, beta 1 subunit-HPRD,BioGRID12429842 
ARHGEF6COOL2 | Cool-2 | KIAA0006 | MRX46 | PIXA | alpha-PIX | alphaPIXRac/Cdc42 guanine nucleotide exchange factor (GEF) 6T-beta-RI interacts with alpha-PIX. This interaction was modeled on a demonstrated interaction between human T-beta-RI and mouse alpha-PIX.BIND15761153 
BMPR2BMPR-II | BMPR3 | BMR2 | BRK-3 | FLJ41585 | FLJ76945 | PPH1 | T-ALKbone morphogenetic protein receptor, type II (serine/threonine kinase)Two-hybridBioGRID7791754 
CAV1CAV | MSTP085 | VIP21caveolin 1, caveolae protein, 22kDa-HPRD,BioGRID11102446 
CD44CDW44 | CSPG8 | ECMR-III | HCELL | IN | LHR | MC56 | MDU2 | MDU3 | MGC10468 | MIC4 | MUTCH-I | Pgp1CD44 molecule (Indian blood group)-HPRD,BioGRID12145287 
CLUAAG4 | APOJ | CLI | KUB1 | MGC24903 | SGP-2 | SGP2 | SP-40 | TRPM-2 | TRPM2clusterin-HPRD,BioGRID8555189 
ApoJ interacts with TGFBR1.BIND8555189 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDa-HPRD12000714 
DAB2DOC-2 | DOC2 | FLJ26626disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)-HPRD,BioGRID11387212 
ENGCD105 | END | FLJ41744 | HHT1 | ORW | ORW1endoglin-HPRD,BioGRID12015308 
FKBP1AFKBP-12 | FKBP1 | FKBP12 | FKBP12C | PKC12 | PKCI2 | PPIASEFK506 binding protein 1A, 12kDa-HPRD,BioGRID7518616 
T-beta-R1 interacts with FKBP12. This interaction was modeled on a demonstrated interaction between T-beta-R1 and FKBP12 both from unspecified species.BIND15761148 
FNTAFPTA | MGC99680 | PGGT1A | PTAR2farnesyltransferase, CAAX box, alpha-HPRD,BioGRID8530343 
KCNK18K2p18.1 | TRESK | TRESK-2 | TRESK2 | TRIKpotassium channel, subfamily K, member 18T-beta-RI interacts with TRIK. This interaction was modeled on a demonstrated interaction between human T-beta-RI and TRIK from an unspecified species.BIND15761153 
OSR1ODDodd-skipped related 1 (Drosophila)T-beta-RI interacts with OSR1. This interaction was modeled on a demonstrated interaction between human T-beta-RI and mouse OSR1.BIND15761153 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD,BioGRID9435577 
PIK3R2P85B | p85 | p85-BETAphosphoinositide-3-kinase, regulatory subunit 2 (beta)-HPRD,BioGRID9435577 
PMLMYL | PP8675 | RNF71 | TRIM19promyelocytic leukemia-HPRD15356634 
cPML interacts with T-beta-RI.BIND15356634 
PPP1CAMGC15877 | MGC1674 | PP-1A | PPP1Aprotein phosphatase 1, catalytic subunit, alpha isoformT-beta-RI interacts with an unspecific isoform of PPP1C. This interaction was modeled on a demonstrated interaction between human T-beta-RI and mouse PPP1C.BIND15761153 
PPP2R2AB55-ALPHA | B55A | FLJ26613 | MGC52248 | PR52A | PR55Aprotein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoformAffinity Capture-Western
Reconstituted Complex		BioGRID9774674 
PPP2R2BB55-BETA | FLJ95686 | MGC24888 | PP2A-B55BETA | PP2A-PR55B | PP2AB-BETA | PP2APR55-BETA | PR2AB-BETA | PR2AB55-BETA | PR2APR55-BETA | PR52B | PR55-BETA | SCA12protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoformTGF-beta-RI interacts with an unspecified isoform of PPP2R2B. This interaction was modeled on a demonstrated interaction between human TGF-beta-RI and mouse PPP2R2B.BIND15761153 
RANARA24 | Gsp1 | TC4RAN, member RAS oncogene familyTGF-beta-RI interacts with RAN. This interaction was modeled on a demonstrated interaction between human TGF-beta-RI and mouse RAN.BIND15761153 
SCRIBCRIB1 | SCRB1 | SCRIB1 | Vartulscribbled homolog (Drosophila)T-beta-RI interacts with an unspecified isoform of CRIB. This was modeled interaction on a demonstrated interaction between human T-beta-RI and mouse CRIB.BIND15761153 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2-HPRD9525694 
Co-fractionationBioGRID11102446 
T-beta-RI interacts with Smad2.BIND15761153 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3-HPRD9311995 
T-beta-RI phosphorylates hMAD-3. This interaction was modeled on a demonstrated interaction between T-beta-RI from an unspecified species and human hMAD-3.BIND8774881 
SMAD4DPC4 | JIP | MADH4SMAD family member 4T-beta-RI phosphorylates hMAD-4. This interaction was modeled on a demonstrated interaction between T-beta-RI from an unspecified species and human hMAD-4.BIND8774881 
Co-fractionationBioGRID11102446 
SMAD7CRCS3 | FLJ16482 | MADH7 | MADH8SMAD family member 7-HPRD,BioGRID9215638 
SMURF1KIAA1625SMAD specific E3 ubiquitin protein ligase 1Affinity Capture-WesternBioGRID14657019 
SMURF2DKFZp686F0270 | MGC138150SMAD specific E3 ubiquitin protein ligase 2-HPRD,BioGRID11163210 |14722617 
SNX6MGC3157 | MSTP010 | TFAF2sorting nexin 6-HPRD,BioGRID11279102 
STRAPMAWD | PT-WD | UNRIPserine/threonine kinase receptor associated proteinT-beta-R1 interacts with STRAP. This interaction was modeled on a demonstrated interaction between T-beta-R1 and STRAP both from unspecified species.BIND15761148 
-HPRD,BioGRID9856985 
TGFB1CED | DPD1 | TGFB | TGFbetatransforming growth factor, beta 1TGF-beta-1 interacts with TGF-beta-R-I. This interaction was modeled on a demonstrated interaction between TGF-beta-1 from an unspecified species and human TGF-beta-R-I.BIND7852346 
-HPRD,BioGRID8235612 
TGFB2MGC116892 | TGF-beta2transforming growth factor, beta 2-HPRD11157754 
TGFB3ARVD | FLJ16571 | TGF-beta3transforming growth factor, beta 3TGF-beta-3 interacts with TGF-beta-R-I. This interaction was modeled on a demonstrated interaction between TGF-beta-3 from an unspecified species and human TGF-beta-R-I.BIND7852346 
-HPRD11850637 |12060054 
|12607775 
TGFBR1AAT5 | ACVRLK4 | ALK-5 | ALK5 | LDS1A | LDS2A | SKR4 | TGFR-1transforming growth factor, beta receptor 1TGF-beta-R-I phosphorylates TGF-beta-R-I. This interaction was modeled on a demonstrated interaction between TGF-beta-R-Is from an unspecified species.BIND8576253 
T-beta-R1 interacts with itself. This interaction was modeled on a demonstrated interaction between T-beta-R1s from unspecified species.BIND15761148 
TGFBR2AAT3 | FAA3 | LDS1B | LDS2B | MFS2 | RIIC | TAAD2 | TGFR-2 | TGFbeta-RIItransforming growth factor, beta receptor II (70/80kDa)-HPRD,BioGRID7890683 
T-beta-R1 interacts with T-beta-R2. This interaction was modeled on a demonstrated interaction between mouse T-beta-R1 and mouse T-beta-R2.BIND14612425 
TGFBR3BGCAN | betaglycantransforming growth factor, beta receptor III-HPRD8106553 |11323414 
TGFBRAP1TRAP-1 | TRAP1transforming growth factor, beta receptor associated protein 1-HPRD11278302 
TSSK1BFKSG81 | SPOGA4 | STK22D | TSSK1testis-specific serine kinase 1BT-beta-RI interacts with STK22D. This interaction was modeled on a demonstrated interaction between human T-beta-RI and mouse STK22D.BIND15761153 
WDR33FLJ11294 | WDC146WD repeat domain 33TGF-beta-RI interacts with FLJ11294. This interaction was modeled on a demonstrated interaction between human TGF-beta-RI and mouse Wdr33.BIND15761153 
WWOXD16S432E | FOR | FRA16D | HHCMA56 | PRO0128 | WOX1WW domain containing oxidoreductaseTGF-beta-RI interacts with an unspecified isoform of WWOX. This interaction was modeled on a demonstrated interaction between human TGF-beta-RI and mouse WWOX.BIND15761153 
XIAPAPI3 | BIRC4 | ILP1 | MIHA | XLP2X-linked inhibitor of apoptosisTGF-beta-RI interacts with XIAP. This interaction was modeled on a demonstrated interaction between TGF-beta-RI from an unspecified species and human XIAP.BIND11356828 
ZAKAZK | MLK7 | MLT | MLTK | MRK | mlklaksterile alpha motif and leucine zipper containing kinase AZK-HPRD,BioGRID15465036 
ZFYVE9MADHIP | NSP | SARA | SMADIPzinc finger, FYVE domain containing 9-HPRD9865696 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/9875821A,m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-101399340001A,m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-124/50631263132m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-125/351236423701Ahsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-128161616231A,m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-130/3011942001Ahsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-13510751081m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-142-3p429443011A,m8hsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-144399440001Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-1814554621A,m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-186108610921Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-2213311337m8hsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-2716171623m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-409-3p366636731A,m8hsa-miR-409-3pCGAAUGUUGCUCGGUGAACCCCU
miR-49039333939m8hsa-miR-490CAACCUGGAGGACUCCAUGCUG
miR-9637833789m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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