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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: TLN1

Summary

GeneID

7094

Symbol

TLN1

Synonyms

ILWEQ|KIAA1027|TLN

Description

talin 1

Locus tag

Gene type

protein-coding

Map location

9p13

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0234

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

HAPLN1

0.72

0.62

AP001362.1

0.63

0.53

BTBD17

0.60

0.52

DHDH

0.60

0.44

CARD16

0.59

0.48

HSPBP1

0.59

0.32

TFR2

0.59

0.42

MATK

0.59

0.48

FCRLA

0.58

0.47

FAM26F

0.57

0.54

Top 10 negatively co-expressed genes

UNC84B

-0.48

-0.63

RFFL

-0.46

-0.59

GAB2

-0.43

-0.57

FMNL2

-0.43

-0.54

FAM123A

-0.43

-0.58

C20orf194

-0.42

-0.52

FRYL

-0.42

-0.52

FAM107B

-0.41

-0.50

NFASC

-0.41

-0.51

FAM124A

-0.41

-0.58

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003779

actin binding

IEA

GO:0030274

LIM domain binding

IPI

10320340

GO:0005488

binding

IEA

GO:0005515

protein binding

ISS

GO:0005200

structural constituent of cytoskeleton

NAS

10610730

GO:0017166

vinculin binding

IPI

15070891

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007044

cell-substrate junction assembly

IEA

GO:0007043

cell-cell junction assembly

TAS

15494027

GO:0007016

cytoskeletal anchoring at plasma membrane

NAS

10610730

GO:0006928

cell motion

NAS

10610730

GO:0030866

cortical actin cytoskeleton organization

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0001726

ruffle

ISS

GO:0005856

cytoskeleton

IEA

GO:0005737

cytoplasm

IEA

GO:0005925

focal adhesion

NAS

cell-cell junction

plasma membrane

IEA

GO:0043231

intracellular membrane-bounded organelle

IDA

18029348

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTA1	ACTA \| ASMA \| CFTD \| CFTD1 \| CFTDM \| MPFD \| NEM1 \| NEM2 \| NEM3	actin, alpha 1, skeletal muscle	-	HPRD	10581178
BCR	ALL \| BCR-ABL1 \| BCR1 \| CML \| D22S11 \| D22S662 \| FLJ16453 \| PHL	breakpoint cluster region	Co-purification	BioGRID	8641358
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	Co-purification	BioGRID	8641358
ITGA1	CD49a \| VLA1	integrin, alpha 1	-	HPRD,BioGRID	11336656
ITGB1	CD29 \| FNRB \| GPIIA \| MDF2 \| MSK12 \| VLA-BETA \| VLAB	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	-	HPRD,BioGRID	11279249
ITGB2	CD18 \| LAD \| LCAMB \| LFA-1 \| MAC-1 \| MF17 \| MFI7	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	-	HPRD	2150484
ITGB3	CD61 \| GP3A \| GPIIIa	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	-	HPRD,BioGRID	10497223 \|11932255
LRP2	DBS \| gp330	low density lipoprotein-related protein 2	-	HPRD	10827173
NRAP	-	nebulin-related anchoring protein	-	HPRD	10320340
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	Co-purification	BioGRID	8641358
PKD1	PBP	polycystic kidney disease 1 (autosomal dominant)	-	HPRD	11113628
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	-	HPRD,BioGRID	7622520
PTK2B	CADTK \| CAKB \| FADK2 \| FAK2 \| FRNK \| PKB \| PTK \| PYK2 \| RAFTK	PTK2B protein tyrosine kinase 2 beta	-	HPRD,BioGRID	9442086
PXN	FLJ16691	paxillin	-	HPRD,BioGRID	7534286
SELE	CD62E \| ELAM \| ELAM1 \| ESEL \| LECAM2	selectin E	Affinity Capture-Western	BioGRID	8609175
TES	DKFZp586B2022 \| MGC1146 \| TESS \| TESS-2	testis derived transcript (3 LIM domains)	TES interacts with talin	BIND	12571287

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124/506	181	187	m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	181	187	m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-182	114	120	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-200bc/429	226	232	1A	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
				hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-326	31	38	1A,m8	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
miR-369-3p	244	250	m8	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-491	324	331	1A,m8	hsa-miR-491^brain	AGUGGGGAACCCUUCCAUGAGGA
miR-9	53	59	m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
miR-96	114	120	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.