Gene Page: TRPM2
Summary ?
| GeneID | 7226 |
| Symbol | TRPM2 |
| Synonyms | EREG1|KNP3|LTRPC2|LTrpC-2|NUDT9H|NUDT9L1|TRPC7 |
| Description | transient receptor potential cation channel subfamily M member 2 |
| Reference | MIM:603749|HGNC:HGNC:12339|Ensembl:ENSG00000142185|HPRD:04777|Vega:OTTHUMG00000040840 |
| Gene type | protein-coding |
| Map location | 21q22.3 |
| Pascal p-value | 0.565 |
| Fetal beta | -2.924 |
| DMG | 1 (# studies) |
| eGene | Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Nucleus accumbens basal ganglia Putamen basal ganglia Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg24355182 | 21 | 45842649 | TRPM2 | 4.682E-4 | 0.418 | 0.046 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs62220412 | 21 | 45759486 | TRPM2 | ENSG00000142185.12 | 2.389E-7 | 0 | -10560 | gtex_brain_putamen_basal |
| rs62220413 | 21 | 45759510 | TRPM2 | ENSG00000142185.12 | 1.485E-6 | 0 | -10536 | gtex_brain_putamen_basal |
| rs55926438 | 21 | 45764222 | TRPM2 | ENSG00000142185.12 | 2.625E-7 | 0 | -5824 | gtex_brain_putamen_basal |
| rs62220416 | 21 | 45766262 | TRPM2 | ENSG00000142185.12 | 6.746E-7 | 0 | -3784 | gtex_brain_putamen_basal |
| rs2096860 | 21 | 45768598 | TRPM2 | ENSG00000142185.12 | 4.842E-8 | 0 | -1448 | gtex_brain_putamen_basal |
| rs56306722 | 21 | 45770681 | TRPM2 | ENSG00000142185.12 | 1.023E-8 | 0 | 635 | gtex_brain_putamen_basal |
| rs9975366 | 21 | 45773265 | TRPM2 | ENSG00000142185.12 | 1.754E-7 | 0 | 3219 | gtex_brain_putamen_basal |
| rs4818910 | 21 | 45776701 | TRPM2 | ENSG00000142185.12 | 2.479E-9 | 0 | 6655 | gtex_brain_putamen_basal |
| rs4818911 | 21 | 45776955 | TRPM2 | ENSG00000142185.12 | 2.475E-9 | 0 | 6909 | gtex_brain_putamen_basal |
| rs11908957 | 21 | 45777144 | TRPM2 | ENSG00000142185.12 | 2.481E-9 | 0 | 7098 | gtex_brain_putamen_basal |
| rs11908983 | 21 | 45777229 | TRPM2 | ENSG00000142185.12 | 2.486E-9 | 0 | 7183 | gtex_brain_putamen_basal |
| rs11702323 | 21 | 45777270 | TRPM2 | ENSG00000142185.12 | 1.856E-10 | 0 | 7224 | gtex_brain_putamen_basal |
| rs11700418 | 21 | 45777446 | TRPM2 | ENSG00000142185.12 | 2.487E-9 | 0 | 7400 | gtex_brain_putamen_basal |
| rs11702292 | 21 | 45777553 | TRPM2 | ENSG00000142185.12 | 2.489E-9 | 0 | 7507 | gtex_brain_putamen_basal |
| rs13313851 | 21 | 45777750 | TRPM2 | ENSG00000142185.12 | 2.489E-9 | 0 | 7704 | gtex_brain_putamen_basal |
| rs55712486 | 21 | 45777764 | TRPM2 | ENSG00000142185.12 | 7.179E-11 | 0 | 7718 | gtex_brain_putamen_basal |
| rs28688635 | 21 | 45777915 | TRPM2 | ENSG00000142185.12 | 2.489E-9 | 0 | 7869 | gtex_brain_putamen_basal |
| rs28709583 | 21 | 45777931 | TRPM2 | ENSG00000142185.12 | 2.489E-9 | 0 | 7885 | gtex_brain_putamen_basal |
| rs28532655 | 21 | 45777937 | TRPM2 | ENSG00000142185.12 | 2.489E-9 | 0 | 7891 | gtex_brain_putamen_basal |
| rs55671108 | 21 | 45778194 | TRPM2 | ENSG00000142185.12 | 2.589E-9 | 0 | 8148 | gtex_brain_putamen_basal |
| rs139826939 | 21 | 45778262 | TRPM2 | ENSG00000142185.12 | 2.614E-9 | 0 | 8216 | gtex_brain_putamen_basal |
| rs2838553 | 21 | 45778294 | TRPM2 | ENSG00000142185.12 | 2.106E-9 | 0 | 8248 | gtex_brain_putamen_basal |
| rs9984977 | 21 | 45778353 | TRPM2 | ENSG00000142185.12 | 2.647E-9 | 0 | 8307 | gtex_brain_putamen_basal |
| rs9977290 | 21 | 45778416 | TRPM2 | ENSG00000142185.12 | 2.677E-9 | 0 | 8370 | gtex_brain_putamen_basal |
| rs9974187 | 21 | 45778702 | TRPM2 | ENSG00000142185.12 | 2.783E-9 | 0 | 8656 | gtex_brain_putamen_basal |
| rs9974189 | 21 | 45778715 | TRPM2 | ENSG00000142185.12 | 2.797E-9 | 0 | 8669 | gtex_brain_putamen_basal |
| rs9974813 | 21 | 45778744 | TRPM2 | ENSG00000142185.12 | 2.803E-9 | 0 | 8698 | gtex_brain_putamen_basal |
| rs9975269 | 21 | 45778847 | TRPM2 | ENSG00000142185.12 | 2.847E-9 | 0 | 8801 | gtex_brain_putamen_basal |
| rs12626312 | 21 | 45778900 | TRPM2 | ENSG00000142185.12 | 2.868E-9 | 0 | 8854 | gtex_brain_putamen_basal |
| rs12626316 | 21 | 45778938 | TRPM2 | ENSG00000142185.12 | 2.885E-9 | 0 | 8892 | gtex_brain_putamen_basal |
| rs200368699 | 21 | 45778959 | TRPM2 | ENSG00000142185.12 | 2.27E-9 | 0 | 8913 | gtex_brain_putamen_basal |
| rs12626318 | 21 | 45778960 | TRPM2 | ENSG00000142185.12 | 3.472E-9 | 0 | 8914 | gtex_brain_putamen_basal |
| rs4818713 | 21 | 45779058 | TRPM2 | ENSG00000142185.12 | 1.027E-10 | 0 | 9012 | gtex_brain_putamen_basal |
| rs4818912 | 21 | 45779170 | TRPM2 | ENSG00000142185.12 | 2.988E-9 | 0 | 9124 | gtex_brain_putamen_basal |
| rs4818913 | 21 | 45779329 | TRPM2 | ENSG00000142185.12 | 3.065E-9 | 0 | 9283 | gtex_brain_putamen_basal |
| rs28615158 | 21 | 45779763 | TRPM2 | ENSG00000142185.12 | 8.231E-9 | 0 | 9717 | gtex_brain_putamen_basal |
| rs28472722 | 21 | 45779774 | TRPM2 | ENSG00000142185.12 | 8.299E-9 | 0 | 9728 | gtex_brain_putamen_basal |
| rs28636732 | 21 | 45780262 | TRPM2 | ENSG00000142185.12 | 3.261E-9 | 0 | 10216 | gtex_brain_putamen_basal |
| rs9980508 | 21 | 45780655 | TRPM2 | ENSG00000142185.12 | 3.853E-9 | 0 | 10609 | gtex_brain_putamen_basal |
| rs73231283 | 21 | 45780669 | TRPM2 | ENSG00000142185.12 | 9.638E-12 | 0 | 10623 | gtex_brain_putamen_basal |
| rs4818714 | 21 | 45781295 | TRPM2 | ENSG00000142185.12 | 4.309E-9 | 0 | 11249 | gtex_brain_putamen_basal |
| rs4818715 | 21 | 45781644 | TRPM2 | ENSG00000142185.12 | 4.659E-9 | 0 | 11598 | gtex_brain_putamen_basal |
| rs4818716 | 21 | 45781735 | TRPM2 | ENSG00000142185.12 | 7.198E-10 | 0 | 11689 | gtex_brain_putamen_basal |
| rs4818915 | 21 | 45782407 | TRPM2 | ENSG00000142185.12 | 7.203E-11 | 0 | 12361 | gtex_brain_putamen_basal |
| rs4169 | 21 | 45782474 | TRPM2 | ENSG00000142185.12 | 5.679E-9 | 0 | 12428 | gtex_brain_putamen_basal |
| rs151176888 | 21 | 45783372 | TRPM2 | ENSG00000142185.12 | 1.039E-10 | 0 | 13326 | gtex_brain_putamen_basal |
| rs2276252 | 21 | 45784271 | TRPM2 | ENSG00000142185.12 | 7.217E-11 | 0 | 14225 | gtex_brain_putamen_basal |
| rs2838554 | 21 | 45784632 | TRPM2 | ENSG00000142185.12 | 7.217E-11 | 0 | 14586 | gtex_brain_putamen_basal |
| rs11908814 | 21 | 45784900 | TRPM2 | ENSG00000142185.12 | 3.163E-8 | 0 | 14854 | gtex_brain_putamen_basal |
| rs111406792 | 21 | 45785066 | TRPM2 | ENSG00000142185.12 | 9.591E-12 | 0 | 15020 | gtex_brain_putamen_basal |
| rs2838555 | 21 | 45785478 | TRPM2 | ENSG00000142185.12 | 1.317E-8 | 0 | 15432 | gtex_brain_putamen_basal |
| rs45457102 | 21 | 45786068 | TRPM2 | ENSG00000142185.12 | 7.227E-11 | 0 | 16022 | gtex_brain_putamen_basal |
| rs762426 | 21 | 45787250 | TRPM2 | ENSG00000142185.12 | 4.144E-8 | 0 | 17204 | gtex_brain_putamen_basal |
| rs9982831 | 21 | 45788034 | TRPM2 | ENSG00000142185.12 | 4.102E-8 | 0 | 17988 | gtex_brain_putamen_basal |
| rs45552731 | 21 | 45789352 | TRPM2 | ENSG00000142185.12 | 1.809E-8 | 0 | 19306 | gtex_brain_putamen_basal |
| rs45480794 | 21 | 45789363 | TRPM2 | ENSG00000142185.12 | 1.198E-6 | 0 | 19317 | gtex_brain_putamen_basal |
| rs45621438 | 21 | 45790238 | TRPM2 | ENSG00000142185.12 | 7.767E-12 | 0 | 20192 | gtex_brain_putamen_basal |
| rs62218764 | 21 | 45791063 | TRPM2 | ENSG00000142185.12 | 1.514E-10 | 0 | 21017 | gtex_brain_putamen_basal |
| rs7277517 | 21 | 45792279 | TRPM2 | ENSG00000142185.12 | 1.259E-9 | 0 | 22233 | gtex_brain_putamen_basal |
| rs62218765 | 21 | 45793331 | TRPM2 | ENSG00000142185.12 | 3.826E-10 | 0 | 23285 | gtex_brain_putamen_basal |
| rs7278527 | 21 | 45793962 | TRPM2 | ENSG00000142185.12 | 4.787E-9 | 0 | 23916 | gtex_brain_putamen_basal |
| rs11088949 | 21 | 45794731 | TRPM2 | ENSG00000142185.12 | 7.496E-12 | 0 | 24685 | gtex_brain_putamen_basal |
| rs12627182 | 21 | 45794867 | TRPM2 | ENSG00000142185.12 | 1.494E-10 | 0 | 24821 | gtex_brain_putamen_basal |
| rs45590835 | 21 | 45795148 | TRPM2 | ENSG00000142185.12 | 7.475E-12 | 0 | 25102 | gtex_brain_putamen_basal |
| rs2838556 | 21 | 45799164 | TRPM2 | ENSG00000142185.12 | 5.175E-8 | 0 | 29118 | gtex_brain_putamen_basal |
| rs4818917 | 21 | 45799280 | TRPM2 | ENSG00000142185.12 | 2.067E-9 | 0 | 29234 | gtex_brain_putamen_basal |
| rs11911248 | 21 | 45803097 | TRPM2 | ENSG00000142185.12 | 4.838E-9 | 0 | 33051 | gtex_brain_putamen_basal |
| rs11911332 | 21 | 45803612 | TRPM2 | ENSG00000142185.12 | 6.697E-12 | 0 | 33566 | gtex_brain_putamen_basal |
| rs62218767 | 21 | 45804596 | TRPM2 | ENSG00000142185.12 | 7.975E-13 | 0 | 34550 | gtex_brain_putamen_basal |
| rs2226686 | 21 | 45805392 | TRPM2 | ENSG00000142185.12 | 5.032E-9 | 0 | 35346 | gtex_brain_putamen_basal |
| rs56195574 | 21 | 45806160 | TRPM2 | ENSG00000142185.12 | 7.941E-13 | 0 | 36114 | gtex_brain_putamen_basal |
| rs62218769 | 21 | 45807376 | TRPM2 | ENSG00000142185.12 | 6.569E-12 | 0 | 37330 | gtex_brain_putamen_basal |
| rs28752243 | 21 | 45807821 | TRPM2 | ENSG00000142185.12 | 9.461E-9 | 0 | 37775 | gtex_brain_putamen_basal |
| rs1556314 | 21 | 45811343 | TRPM2 | ENSG00000142185.12 | 1.024E-8 | 0 | 41297 | gtex_brain_putamen_basal |
| rs2838557 | 21 | 45812703 | TRPM2 | ENSG00000142185.12 | 6.4E-9 | 0 | 42657 | gtex_brain_putamen_basal |
| rs11378494 | 21 | 45813170 | TRPM2 | ENSG00000142185.12 | 1.104E-8 | 0 | 43124 | gtex_brain_putamen_basal |
| rs1011557 | 21 | 45822606 | TRPM2 | ENSG00000142185.12 | 5.423E-7 | 0 | 52560 | gtex_brain_putamen_basal |
| rs1785440 | 21 | 45826803 | TRPM2 | ENSG00000142185.12 | 7.276E-7 | 0 | 56757 | gtex_brain_putamen_basal |
| rs1785467 | 21 | 45838632 | TRPM2 | ENSG00000142185.12 | 8.549E-7 | 0 | 68586 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005509 | calcium ion binding | IEA | - | |
| GO:0005262 | calcium channel activity | TAS | 9806837 | |
| GO:0005272 | sodium channel activity | IEA | - | |
| GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds | IEA | - | |
| GO:0016787 | hydrolase activity | IEA | - | |
| GO:0005216 | ion channel activity | IEA | - | |
| GO:0047631 | ADP-ribose diphosphatase activity | IEA | - | |
| GO:0031402 | sodium ion binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005975 | carbohydrate metabolic process | IEA | - | |
| GO:0006816 | calcium ion transport | TAS | 9806837 | |
| GO:0006814 | sodium ion transport | IEA | - | |
| GO:0006811 | ion transport | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0016020 | membrane | IEA | - | |
| GO:0016021 | integral to membrane | IEA | - | |
| GO:0005887 | integral to plasma membrane | TAS | 9806837 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PARENT MTOR SIGNALING UP | 567 | 375 | All SZGR 2.0 genes in this pathway |
| BROWN MYELOID CELL DEVELOPMENT UP | 165 | 100 | All SZGR 2.0 genes in this pathway |
| XU GH1 AUTOCRINE TARGETS UP | 268 | 157 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER WITH H3K9ME3 UP | 141 | 75 | All SZGR 2.0 genes in this pathway |
| GRADE COLON CANCER UP | 871 | 505 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MCV6 LCP WITH H3K27ME3 | 29 | 11 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF LCP WITH H3K27ME3 | 70 | 35 | All SZGR 2.0 genes in this pathway |
| VERHAAK GLIOBLASTOMA MESENCHYMAL | 216 | 130 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP C | 92 | 60 | All SZGR 2.0 genes in this pathway |
| SERVITJA ISLET HNF1A TARGETS DN | 109 | 71 | All SZGR 2.0 genes in this pathway |