SZGR2

Summary ?

GeneID	7284
Symbol	TUFM
Synonyms	COXPD4\|EF-TuMT\|EFTU\|P43
Description	Tu translation elongation factor, mitochondrial
Reference	MIM:602389\|HGNC:HGNC:12420\|Ensembl:ENSG00000178952\|HPRD:03861\|Vega:OTTHUMG00000097039
Gene type	protein-coding
Map location	16p11.2
Pascal p-value	0.077
Sherlock p-value	0.333
Fetal beta	0.178
DMG	1 (# studies)
eGene	Caudate basal ganglia Frontal Cortex BA9 Hippocampus Nucleus accumbens basal ganglia Putamen basal ganglia
Support	G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
DMG:vanEijk_2014	Genome-wide DNA methylation analysis	This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250).	1
GSMA_IIE	Genome scan meta-analysis (European-ancestry samples)	Psr: 0.01775
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0044

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg07597976	16	28943019	TUFM	0.002	-4.136		DMG:vanEijk_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	TSS distance	eQTL type
rs376659973	16	28330968	TUFM	ENSG00000178952.4	2.677E-7	526761	gtex_brain_putamen_basal
rs201963833	16	28330973	TUFM	ENSG00000178952.4	2.217E-6	526756	gtex_brain_putamen_basal
rs2650492	16	28333411	TUFM	ENSG00000178952.4	3.745E-7	524318	gtex_brain_putamen_basal
rs2726034	16	28336882	TUFM	ENSG00000178952.4	3.042E-7	520847	gtex_brain_putamen_basal
rs2726033	16	28338039	TUFM	ENSG00000178952.4	1.142E-6	519690	gtex_brain_putamen_basal
rs2726032	16	28338043	TUFM	ENSG00000178952.4	1.143E-6	519686	gtex_brain_putamen_basal
rs6498084	16	28340854	TUFM	ENSG00000178952.4	3.174E-6	516875	gtex_brain_putamen_basal
rs12598357	16	28340945	TUFM	ENSG00000178952.4	8.634E-7	516784	gtex_brain_putamen_basal
rs2726036	16	28347140	TUFM	ENSG00000178952.4	7.577E-8	510589	gtex_brain_putamen_basal
rs865719	16	28379443	TUFM	ENSG00000178952.4	1.346E-6	478286	gtex_brain_putamen_basal
rs62032566	16	28383243	TUFM	ENSG00000178952.4	6.699E-7	474486	gtex_brain_putamen_basal
rs62034276	16	28473465	TUFM	ENSG00000178952.4	3.795E-7	384264	gtex_brain_putamen_basal
rs149299	16	28485141	TUFM	ENSG00000178952.4	4.572E-7	372588	gtex_brain_putamen_basal
rs151179	16	28487056	TUFM	ENSG00000178952.4	8.178E-8	370673	gtex_brain_putamen_basal
rs201668183	16	28487212	TUFM	ENSG00000178952.4	1.19E-7	370517	gtex_brain_putamen_basal
rs181195	16	28488369	TUFM	ENSG00000178952.4	4.65E-7	369360	gtex_brain_putamen_basal
rs28374519	16	28489342	TUFM	ENSG00000178952.4	5.396E-7	368387	gtex_brain_putamen_basal
rs34839	16	28489346	TUFM	ENSG00000178952.4	8.184E-7	368383	gtex_brain_putamen_basal
rs151181	16	28490517	TUFM	ENSG00000178952.4	8.178E-8	367212	gtex_brain_putamen_basal
rs139457431	16	28491534	TUFM	ENSG00000178952.4	9.307E-8	366195	gtex_brain_putamen_basal
rs151303	16	28492510	TUFM	ENSG00000178952.4	8.178E-8	365219	gtex_brain_putamen_basal
rs34838	16	28494350	TUFM	ENSG00000178952.4	1.063E-6	363379	gtex_brain_putamen_basal
rs42861	16	28494421	TUFM	ENSG00000178952.4	2.286E-7	363308	gtex_brain_putamen_basal
rs34836	16	28494823	TUFM	ENSG00000178952.4	2.152E-7	362906	gtex_brain_putamen_basal
rs151182	16	28495752	TUFM	ENSG00000178952.4	8.178E-8	361977	gtex_brain_putamen_basal
rs151301	16	28497059	TUFM	ENSG00000178952.4	8.178E-8	360670	gtex_brain_putamen_basal
rs34835	16	28499291	TUFM	ENSG00000178952.4	2.602E-7	358438	gtex_brain_putamen_basal
rs149301	16	28499659	TUFM	ENSG00000178952.4	1.156E-7	358070	gtex_brain_putamen_basal
rs200860698	16	28502409	TUFM	ENSG00000178952.4	7.254E-9	355320	gtex_brain_putamen_basal
rs27741	16	28504181	TUFM	ENSG00000178952.4	8.475E-10	353548	gtex_brain_putamen_basal
rs149271	16	28506872	TUFM	ENSG00000178952.4	1.841E-8	350857	gtex_brain_putamen_basal
rs180743	16	28507644	TUFM	ENSG00000178952.4	2.004E-8	350085	gtex_brain_putamen_basal
rs180744	16	28508048	TUFM	ENSG00000178952.4	1.911E-8	349681	gtex_brain_putamen_basal
rs151174	16	28508069	TUFM	ENSG00000178952.4	2.179E-7	349660	gtex_brain_putamen_basal
rs40831	16	28508447	TUFM	ENSG00000178952.4	3.023E-8	349282	gtex_brain_putamen_basal
rs40834	16	28510393	TUFM	ENSG00000178952.4	6.081E-7	347336	gtex_brain_putamen_basal
rs40836	16	28510537	TUFM	ENSG00000178952.4	3.423E-6	347192	gtex_brain_putamen_basal
rs40837	16	28510845	TUFM	ENSG00000178952.4	1.042E-6	346884	gtex_brain_putamen_basal
rs202174388	16	28512888	TUFM	ENSG00000178952.4	1.808E-6	344841	gtex_brain_putamen_basal
rs26528	16	28517709	TUFM	ENSG00000178952.4	1.279E-6	340020	gtex_brain_putamen_basal
rs153109	16	28519096	TUFM	ENSG00000178952.4	1.279E-6	338633	gtex_brain_putamen_basal
rs111857492	16	28520325	TUFM	ENSG00000178952.4	1.586E-6	337404	gtex_brain_putamen_basal
rs56354901	16	28523144	TUFM	ENSG00000178952.4	1.148E-6	334585	gtex_brain_putamen_basal
rs240707	16	28524612	TUFM	ENSG00000178952.4	2.705E-6	333117	gtex_brain_putamen_basal
rs153111	16	28524723	TUFM	ENSG00000178952.4	1.457E-6	333006	gtex_brain_putamen_basal
rs153106	16	28526897	TUFM	ENSG00000178952.4	3.853E-8	330832	gtex_brain_putamen_basal
rs62034318	16	28527221	TUFM	ENSG00000178952.4	9.889E-7	330508	gtex_brain_putamen_basal
rs79046494	16	28527326	TUFM	ENSG00000178952.4	9.912E-7	330403	gtex_brain_putamen_basal
rs28449958	16	28528781	TUFM	ENSG00000178952.4	1.036E-6	328948	gtex_brain_putamen_basal
rs240705	16	28529716	TUFM	ENSG00000178952.4	5.011E-8	328013	gtex_brain_putamen_basal
rs240704	16	28529949	TUFM	ENSG00000178952.4	1.087E-7	327780	gtex_brain_putamen_basal
rs4787458	16	28531287	TUFM	ENSG00000178952.4	3.948E-6	326442	gtex_brain_putamen_basal
rs240702	16	28531353	TUFM	ENSG00000178952.4	3.563E-8	326376	gtex_brain_putamen_basal
rs62034319	16	28532188	TUFM	ENSG00000178952.4	3.581E-8	325541	gtex_brain_putamen_basal
rs28698667	16	28533071	TUFM	ENSG00000178952.4	1.976E-8	324658	gtex_brain_putamen_basal
rs62034321	16	28534038	TUFM	ENSG00000178952.4	1.976E-8	323691	gtex_brain_putamen_basal
rs4788085	16	28535003	TUFM	ENSG00000178952.4	1.803E-8	322726	gtex_brain_putamen_basal
rs28772958	16	28535305	TUFM	ENSG00000178952.4	1.803E-8	322424	gtex_brain_putamen_basal
rs62034322	16	28535834	TUFM	ENSG00000178952.4	4.873E-7	321895	gtex_brain_putamen_basal
rs62034323	16	28536473	TUFM	ENSG00000178952.4	1.976E-8	321256	gtex_brain_putamen_basal
rs62034324	16	28536762	TUFM	ENSG00000178952.4	2.152E-8	320967	gtex_brain_putamen_basal
rs2106480	16	28537971	TUFM	ENSG00000178952.4	1.803E-8	319758	gtex_brain_putamen_basal
rs62034325	16	28538640	TUFM	ENSG00000178952.4	5.004E-7	319089	gtex_brain_putamen_basal
rs62034326	16	28539293	TUFM	ENSG00000178952.4	1.977E-8	318436	gtex_brain_putamen_basal
rs199618702	16	28539378	TUFM	ENSG00000178952.4	2.041E-6	318351	gtex_brain_putamen_basal
rs189278832	16	28539386	TUFM	ENSG00000178952.4	2.071E-8	318343	gtex_brain_putamen_basal
rs200840505	16	28539396	TUFM	ENSG00000178952.4	1.03E-6	318333	gtex_brain_putamen_basal
rs143626010	16	28539398	TUFM	ENSG00000178952.4	7.904E-7	318331	gtex_brain_putamen_basal
rs4788084	16	28539848	TUFM	ENSG00000178952.4	1.945E-8	317881	gtex_brain_putamen_basal
rs8046271	16	28541394	TUFM	ENSG00000178952.4	2.42E-8	316335	gtex_brain_putamen_basal
rs12446550	16	28543381	TUFM	ENSG00000178952.4	1.976E-8	314348	gtex_brain_putamen_basal
rs4788083	16	28545449	TUFM	ENSG00000178952.4	1.803E-8	312280	gtex_brain_putamen_basal
rs3785354	16	28550667	TUFM	ENSG00000178952.4	4.837E-7	307062	gtex_brain_putamen_basal
rs1074631	16	28554108	TUFM	ENSG00000178952.4	1.048E-6	303621	gtex_brain_putamen_basal
rs4787457	16	28555400	TUFM	ENSG00000178952.4	4.985E-7	302329	gtex_brain_putamen_basal
rs9926245	16	28555706	TUFM	ENSG00000178952.4	1.907E-8	302023	gtex_brain_putamen_basal
rs4788081	16	28556147	TUFM	ENSG00000178952.4	1.048E-6	301582	gtex_brain_putamen_basal
rs201107789	16	28556564	TUFM	ENSG00000178952.4	6.798E-7	301165	gtex_brain_putamen_basal
rs4788080	16	28558081	TUFM	ENSG00000178952.4	5.367E-7	299648	gtex_brain_putamen_basal
rs7202948	16	28558289	TUFM	ENSG00000178952.4	1.77E-8	299440	gtex_brain_putamen_basal
rs4788079	16	28559363	TUFM	ENSG00000178952.4	5.529E-7	298366	gtex_brain_putamen_basal
rs4787456	16	28559573	TUFM	ENSG00000178952.4	4.985E-7	298156	gtex_brain_putamen_basal
rs4788078	16	28559981	TUFM	ENSG00000178952.4	4.985E-7	297748	gtex_brain_putamen_basal
rs112366001	16	28561785	TUFM	ENSG00000178952.4	3.47E-6	295944	gtex_brain_putamen_basal
rs13331170	16	28561982	TUFM	ENSG00000178952.4	2.935E-8	295747	gtex_brain_putamen_basal
rs62034350	16	28562256	TUFM	ENSG00000178952.4	4.987E-7	295473	gtex_brain_putamen_basal
rs151228	16	28563026	TUFM	ENSG00000178952.4	3.351E-6	294703	gtex_brain_putamen_basal
rs62034351	16	28565489	TUFM	ENSG00000178952.4	3.687E-6	292240	gtex_brain_putamen_basal
rs7191618	16	28565667	TUFM	ENSG00000178952.4	2.906E-8	292062	gtex_brain_putamen_basal
rs7187604	16	28565953	TUFM	ENSG00000178952.4	5.487E-7	291776	gtex_brain_putamen_basal
rs3859172	16	28566158	TUFM	ENSG00000178952.4	2.906E-8	291571	gtex_brain_putamen_basal
rs4788076	16	28570005	TUFM	ENSG00000178952.4	5.08E-7	287724	gtex_brain_putamen_basal
rs370527719	16	28570703	TUFM	ENSG00000178952.4	1.172E-6	287026	gtex_brain_putamen_basal
rs140001625	16	28575917	TUFM	ENSG00000178952.4	6.242E-8	281812	gtex_brain_putamen_basal
rs150072875	16	28579915	TUFM	ENSG00000178952.4	1.483E-6	277814	gtex_brain_putamen_basal
rs56396270	16	28580829	TUFM	ENSG00000178952.4	4.95E-7	276900	gtex_brain_putamen_basal
rs12447461	16	28582941	TUFM	ENSG00000178952.4	4.954E-7	274788	gtex_brain_putamen_basal
rs112191041	16	28583362	TUFM	ENSG00000178952.4	5.038E-7	274367	gtex_brain_putamen_basal
rs111693583	16	28583610	TUFM	ENSG00000178952.4	4.957E-7	274119	gtex_brain_putamen_basal
rs11074911	16	28583865	TUFM	ENSG00000178952.4	4.957E-7	273864	gtex_brain_putamen_basal
rs56209193	16	28585636	TUFM	ENSG00000178952.4	5.073E-7	272093	gtex_brain_putamen_basal
rs7193402	16	28586127	TUFM	ENSG00000178952.4	4.96E-7	271602	gtex_brain_putamen_basal
rs7186573	16	28587389	TUFM	ENSG00000178952.4	4.965E-7	270340	gtex_brain_putamen_basal
rs62034358	16	28587597	TUFM	ENSG00000178952.4	4.968E-7	270132	gtex_brain_putamen_basal
rs12445823	16	28588049	TUFM	ENSG00000178952.4	4.971E-7	269680	gtex_brain_putamen_basal
rs12445744	16	28588395	TUFM	ENSG00000178952.4	4.971E-7	269334	gtex_brain_putamen_basal
rs12448429	16	28588443	TUFM	ENSG00000178952.4	4.864E-7	269286	gtex_brain_putamen_basal
rs4787455	16	28589455	TUFM	ENSG00000178952.4	4.979E-7	268274	gtex_brain_putamen_basal
rs7190771	16	28590030	TUFM	ENSG00000178952.4	3.91E-7	267699	gtex_brain_putamen_basal
rs112047757	16	28590862	TUFM	ENSG00000178952.4	4.979E-7	266867	gtex_brain_putamen_basal
rs17707300	16	28593347	TUFM	ENSG00000178952.4	4.985E-7	264382	gtex_brain_putamen_basal
rs4788074	16	28593597	TUFM	ENSG00000178952.4	4.985E-7	264132	gtex_brain_putamen_basal
rs4788073	16	28594549	TUFM	ENSG00000178952.4	4.985E-7	263180	gtex_brain_putamen_basal
rs17640009	16	28595700	TUFM	ENSG00000178952.4	5.128E-7	262029	gtex_brain_putamen_basal
rs75539558	16	28595810	TUFM	ENSG00000178952.4	5.166E-7	261919	gtex_brain_putamen_basal
rs55792032	16	28599411	TUFM	ENSG00000178952.4	5.256E-7	258318	gtex_brain_putamen_basal
rs62034359	16	28600091	TUFM	ENSG00000178952.4	5.213E-7	257638	gtex_brain_putamen_basal
rs112479807	16	28600201	TUFM	ENSG00000178952.4	5.301E-7	257528	gtex_brain_putamen_basal
rs2077031	16	28603168	TUFM	ENSG00000178952.4	4.941E-7	254561	gtex_brain_putamen_basal
rs762634	16	28603335	TUFM	ENSG00000178952.4	1.659E-6	254394	gtex_brain_putamen_basal
rs710410	16	28603342	TUFM	ENSG00000178952.4	1.771E-6	254387	gtex_brain_putamen_basal
rs1059491	16	28603655	TUFM	ENSG00000178952.4	4.889E-7	254074	gtex_brain_putamen_basal
rs62031560	16	28605915	TUFM	ENSG00000178952.4	4.278E-7	251814	gtex_brain_putamen_basal
rs113208333	16	28606160	TUFM	ENSG00000178952.4	4.054E-7	251569	gtex_brain_putamen_basal
rs4149406	16	28607070	TUFM	ENSG00000178952.4	3.375E-7	250659	gtex_brain_putamen_basal
rs1690407	16	28607228	TUFM	ENSG00000178952.4	7.496E-7	250501	gtex_brain_putamen_basal
rs1136703	16	28607232	TUFM	ENSG00000178952.4	1.291E-6	250497	gtex_brain_putamen_basal
rs4115668	16	28607532	TUFM	ENSG00000178952.4	4.752E-6	250197	gtex_brain_putamen_basal
rs743590	16	28608230	TUFM	ENSG00000178952.4	2.705E-7	249499	gtex_brain_putamen_basal
rs762633	16	28608341	TUFM	ENSG00000178952.4	2.648E-7	249388	gtex_brain_putamen_basal
rs35175818	16	28608746	TUFM	ENSG00000178952.4	2.482E-7	248983	gtex_brain_putamen_basal
rs4149398	16	28608938	TUFM	ENSG00000178952.4	8.92E-8	248791	gtex_brain_putamen_basal
rs62031562	16	28609329	TUFM	ENSG00000178952.4	1.068E-7	248400	gtex_brain_putamen_basal
rs11074907	16	28613965	TUFM	ENSG00000178952.4	1.337E-8	243764	gtex_brain_putamen_basal
rs11074905	16	28614472	TUFM	ENSG00000178952.4	3.332E-6	243257	gtex_brain_putamen_basal
rs7191548	16	28614734	TUFM	ENSG00000178952.4	3.254E-9	242995	gtex_brain_putamen_basal
rs6498091	16	28616259	TUFM	ENSG00000178952.4	2.589E-9	241470	gtex_brain_putamen_basal
rs4788070	16	28616399	TUFM	ENSG00000178952.4	2.951E-9	241330	gtex_brain_putamen_basal
rs4788069	16	28616665	TUFM	ENSG00000178952.4	2.448E-9	241064	gtex_brain_putamen_basal
rs4788068	16	28616723	TUFM	ENSG00000178952.4	2.426E-9	241006	gtex_brain_putamen_basal
rs1042157	16	28617057	TUFM	ENSG00000178952.4	2.321E-9	240672	gtex_brain_putamen_basal
rs6839	16	28617128	TUFM	ENSG00000178952.4	3.206E-6	240601	gtex_brain_putamen_basal
rs9282864	16	28617308	TUFM	ENSG00000178952.4	9.398E-8	240421	gtex_brain_putamen_basal
rs41278162	16	28617361	TUFM	ENSG00000178952.4	1.749E-6	240368	gtex_brain_putamen_basal
rs9282861	16	28617514	TUFM	ENSG00000178952.4	2.16E-6	240215	gtex_brain_putamen_basal
rs3176926	16	28617552	TUFM	ENSG00000178952.4	4.177E-7	240177	gtex_brain_putamen_basal
rs4149394	16	28617574	TUFM	ENSG00000178952.4	3.987E-9	240155	gtex_brain_putamen_basal
rs4149393	16	28617595	TUFM	ENSG00000178952.4	3.669E-9	240134	gtex_brain_putamen_basal
rs79533802	16	28617794	TUFM	ENSG00000178952.4	4.524E-8	239935	gtex_brain_putamen_basal
rs79039694	16	28617795	TUFM	ENSG00000178952.4	5.096E-8	239934	gtex_brain_putamen_basal
rs4149392	16	28617813	TUFM	ENSG00000178952.4	1.247E-9	239916	gtex_brain_putamen_basal
rs200409943	16	28617884	TUFM	ENSG00000178952.4	3.093E-8	239845	gtex_brain_putamen_basal
rs75301646	16	28617885	TUFM	ENSG00000178952.4	8.772E-10	239844	gtex_brain_putamen_basal
rs74459546	16	28617888	TUFM	ENSG00000178952.4	3.24E-9	239841	gtex_brain_putamen_basal
rs116840534	16	28617890	TUFM	ENSG00000178952.4	3.348E-9	239839	gtex_brain_putamen_basal
rs143299878	16	28617930	TUFM	ENSG00000178952.4	4.417E-8	239799	gtex_brain_putamen_basal
rs111384198	16	28617934	TUFM	ENSG00000178952.4	5.198E-9	239795	gtex_brain_putamen_basal
rs4149391	16	28617971	TUFM	ENSG00000178952.4	2.858E-10	239758	gtex_brain_putamen_basal
rs4149390	16	28617974	TUFM	ENSG00000178952.4	2.857E-10	239755	gtex_brain_putamen_basal
rs41278158	16	28617993	TUFM	ENSG00000178952.4	4.995E-10	239736	gtex_brain_putamen_basal
rs4149389	16	28618011	TUFM	ENSG00000178952.4	1.348E-7	239718	gtex_brain_putamen_basal
rs34954534	16	28618018	TUFM	ENSG00000178952.4	3.19E-8	239711	gtex_brain_putamen_basal
rs41278156	16	28618037	TUFM	ENSG00000178952.4	3.687E-6	239692	gtex_brain_putamen_basal
rs4149388	16	28618047	TUFM	ENSG00000178952.4	1.082E-6	239682	gtex_brain_putamen_basal
rs3020806	16	28618065	TUFM	ENSG00000178952.4	5.813E-7	239664	gtex_brain_putamen_basal
rs74752114	16	28618068	TUFM	ENSG00000178952.4	5.819E-7	239661	gtex_brain_putamen_basal
rs3020805	16	28618071	TUFM	ENSG00000178952.4	5.824E-7	239658	gtex_brain_putamen_basal
rs9282862	16	28618237	TUFM	ENSG00000178952.4	1.608E-6	239492	gtex_brain_putamen_basal
rs2925623	16	28618446	TUFM	ENSG00000178952.4	4.81E-8	239283	gtex_brain_putamen_basal
rs2925624	16	28618545	TUFM	ENSG00000178952.4	3.593E-6	239184	gtex_brain_putamen_basal
rs3020804	16	28618636	TUFM	ENSG00000178952.4	2.156E-9	239093	gtex_brain_putamen_basal
rs11648192	16	28618708	TUFM	ENSG00000178952.4	1.601E-8	239021	gtex_brain_putamen_basal
rs3020803	16	28618914	TUFM	ENSG00000178952.4	2.992E-9	238815	gtex_brain_putamen_basal
rs2925629	16	28619076	TUFM	ENSG00000178952.4	2.311E-9	238653	gtex_brain_putamen_basal
rs2925630	16	28619132	TUFM	ENSG00000178952.4	2.289E-9	238597	gtex_brain_putamen_basal
rs56169261	16	28619178	TUFM	ENSG00000178952.4	4.349E-6	238551	gtex_brain_putamen_basal
rs56091264	16	28619179	TUFM	ENSG00000178952.4	8.236E-10	238550	gtex_brain_putamen_basal
rs56305122	16	28619180	TUFM	ENSG00000178952.4	6.701E-9	238549	gtex_brain_putamen_basal
rs1126447	16	28619911	TUFM	ENSG00000178952.4	2.672E-9	237818	gtex_brain_putamen_basal
rs1126446	16	28619920	TUFM	ENSG00000178952.4	1.83E-8	237809	gtex_brain_putamen_basal
rs1690405	16	28620311	TUFM	ENSG00000178952.4	1.091E-6	237418	gtex_brain_putamen_basal
rs750155	16	28620572	TUFM	ENSG00000178952.4	4.797E-6	237157	gtex_brain_putamen_basal
rs4787452	16	28623115	TUFM	ENSG00000178952.4	6.521E-7	234614	gtex_brain_putamen_basal
rs28729187	16	28626966	TUFM	ENSG00000178952.4	1.075E-8	230763	gtex_brain_putamen_basal
rs28480369	16	28627004	TUFM	ENSG00000178952.4	1.07E-8	230725	gtex_brain_putamen_basal
rs28676837	16	28627063	TUFM	ENSG00000178952.4	1.365E-8	230666	gtex_brain_putamen_basal
rs398119327	16	28628326	TUFM	ENSG00000178952.4	6.938E-8	229403	gtex_brain_putamen_basal
rs6498089	16	28629300	TUFM	ENSG00000178952.4	8.971E-9	228429	gtex_brain_putamen_basal
rs71140983	16	28631061	TUFM	ENSG00000178952.4	2.156E-6	226668	gtex_brain_putamen_basal
rs28410083	16	28631360	TUFM	ENSG00000178952.4	8.864E-9	226369	gtex_brain_putamen_basal
rs62031607	16	28631530	TUFM	ENSG00000178952.4	1.929E-8	226199	gtex_brain_putamen_basal
rs1968752	16	28631585	TUFM	ENSG00000178952.4	8.999E-9	226144	gtex_brain_putamen_basal
rs1968751	16	28631759	TUFM	ENSG00000178952.4	8.969E-9	225970	gtex_brain_putamen_basal
rs2411453	16	28632021	TUFM	ENSG00000178952.4	2.971E-8	225708	gtex_brain_putamen_basal
rs8049739	16	28632288	TUFM	ENSG00000178952.4	9.092E-9	225441	gtex_brain_putamen_basal
rs4788062	16	28641179	TUFM	ENSG00000178952.4	1.058E-8	216550	gtex_brain_putamen_basal
rs4788061	16	28643300	TUFM	ENSG00000178952.4	2.743E-7	214429	gtex_brain_putamen_basal
rs12446008	16	28644459	TUFM	ENSG00000178952.4	2.793E-6	213270	gtex_brain_putamen_basal
rs9929198	16	28644980	TUFM	ENSG00000178952.4	2.557E-6	212749	gtex_brain_putamen_basal
rs111820348	16	28645127	TUFM	ENSG00000178952.4	5.233E-7	212602	gtex_brain_putamen_basal
rs3987654	16	28647568	TUFM	ENSG00000178952.4	8.432E-7	210161	gtex_brain_putamen_basal
rs35626515	16	28649651	TUFM	ENSG00000178952.4	4.615E-8	208078	gtex_brain_putamen_basal
rs3959263	16	28651064	TUFM	ENSG00000178952.4	1.185E-6	206665	gtex_brain_putamen_basal
rs72793807	16	28651732	TUFM	ENSG00000178952.4	5.428E-7	205997	gtex_brain_putamen_basal
rs117313280	16	28651893	TUFM	ENSG00000178952.4	7.687E-7	205836	gtex_brain_putamen_basal
rs451689	16	28741236	TUFM	ENSG00000178952.4	1.006E-6	116493	gtex_brain_putamen_basal
rs138592330	16	28754487	TUFM	ENSG00000178952.4	2.722E-7	103242	gtex_brain_putamen_basal
rs378421	16	28754684	TUFM	ENSG00000178952.4	5.049E-8	103045	gtex_brain_putamen_basal
rs200928817	16	28823040	TUFM	ENSG00000178952.4	2.594E-10	34689	gtex_brain_putamen_basal
rs62036613	16	28823097	TUFM	ENSG00000178952.4	3.908E-9	34632	gtex_brain_putamen_basal
rs62036614	16	28824685	TUFM	ENSG00000178952.4	3.9E-9	33044	gtex_brain_putamen_basal
rs113029997	16	28825100	TUFM	ENSG00000178952.4	4.312E-10	32629	gtex_brain_putamen_basal
rs11860513	16	28825420	TUFM	ENSG00000178952.4	4.042E-10	32309	gtex_brain_putamen_basal
rs2008514	16	28825605	TUFM	ENSG00000178952.4	4.89E-10	32124	gtex_brain_putamen_basal
rs1987472	16	28825777	TUFM	ENSG00000178952.4	4.89E-10	31952	gtex_brain_putamen_basal
rs1987471	16	28825866	TUFM	ENSG00000178952.4	8.264E-10	31863	gtex_brain_putamen_basal
rs56186137	16	28825953	TUFM	ENSG00000178952.4	4.89E-10	31776	gtex_brain_putamen_basal
rs62036616	16	28826307	TUFM	ENSG00000178952.4	4.549E-9	31422	gtex_brain_putamen_basal
rs62036617	16	28827498	TUFM	ENSG00000178952.4	4.89E-10	30231	gtex_brain_putamen_basal
rs62036618	16	28828834	TUFM	ENSG00000178952.4	5.954E-12	28895	gtex_brain_putamen_basal
rs187668816	16	28829117	TUFM	ENSG00000178952.4	1.826E-9	28612	gtex_brain_putamen_basal
rs4788095	16	28831359	TUFM	ENSG00000178952.4	4.89E-10	26370	gtex_brain_putamen_basal
rs72793809	16	28832382	TUFM	ENSG00000178952.4	4.89E-10	25347	gtex_brain_putamen_basal
rs62036620	16	28833097	TUFM	ENSG00000178952.4	4.89E-10	24632	gtex_brain_putamen_basal
rs62036621	16	28833299	TUFM	ENSG00000178952.4	4.89E-10	24430	gtex_brain_putamen_basal
rs201131521	16	28834254	TUFM	ENSG00000178952.4	5.462E-10	23475	gtex_brain_putamen_basal
rs138159013	16	28835682	TUFM	ENSG00000178952.4	4.988E-10	22047	gtex_brain_putamen_basal
rs4451951	16	28836205	TUFM	ENSG00000178952.4	4.89E-10	21524	gtex_brain_putamen_basal
rs62036622	16	28837203	TUFM	ENSG00000178952.4	4.519E-9	20526	gtex_brain_putamen_basal
rs8049439	16	28837515	TUFM	ENSG00000178952.4	3.612E-11	20214	gtex_brain_putamen_basal
rs8062405	16	28837906	TUFM	ENSG00000178952.4	1.856E-9	19823	gtex_brain_putamen_basal
rs72793811	16	28839392	TUFM	ENSG00000178952.4	4.519E-9	18337	gtex_brain_putamen_basal
rs78613234	16	28839425	TUFM	ENSG00000178952.4	4.89E-10	18304	gtex_brain_putamen_basal
rs62036623	16	28839735	TUFM	ENSG00000178952.4	4.519E-9	17994	gtex_brain_putamen_basal
rs201363442	16	28839929	TUFM	ENSG00000178952.4	2.324E-8	17800	gtex_brain_putamen_basal
rs62036624	16	28839930	TUFM	ENSG00000178952.4	4.89E-10	17799	gtex_brain_putamen_basal
rs72793812	16	28840381	TUFM	ENSG00000178952.4	2.401E-9	17348	gtex_brain_putamen_basal
rs12443881	16	28841777	TUFM	ENSG00000178952.4	4.519E-9	15952	gtex_brain_putamen_basal
rs55877496	16	28842584	TUFM	ENSG00000178952.4	5.237E-9	15145	gtex_brain_putamen_basal
rs55991577	16	28843025	TUFM	ENSG00000178952.4	4.89E-10	14704	gtex_brain_putamen_basal
rs56358680	16	28843118	TUFM	ENSG00000178952.4	4.89E-10	14611	gtex_brain_putamen_basal
rs62036626	16	28844284	TUFM	ENSG00000178952.4	4.89E-10	13445	gtex_brain_putamen_basal
rs62036657	16	28844365	TUFM	ENSG00000178952.4	4.89E-10	13364	gtex_brain_putamen_basal
rs141681863	16	28845027	TUFM	ENSG00000178952.4	4.89E-10	12702	gtex_brain_putamen_basal
rs12444171	16	28845251	TUFM	ENSG00000178952.4	4.89E-10	12478	gtex_brain_putamen_basal
rs56404918	16	28846840	TUFM	ENSG00000178952.4	4.89E-10	10889	gtex_brain_putamen_basal
rs55719896	16	28846866	TUFM	ENSG00000178952.4	4.89E-10	10863	gtex_brain_putamen_basal
rs55830740	16	28847149	TUFM	ENSG00000178952.4	4.89E-10	10580	gtex_brain_putamen_basal
rs12928404	16	28847246	TUFM	ENSG00000178952.4	2.373E-10	10483	gtex_brain_putamen_basal
rs12325113	16	28848668	TUFM	ENSG00000178952.4	4.519E-9	9061	gtex_brain_putamen_basal
rs12325278	16	28848818	TUFM	ENSG00000178952.4	4.89E-10	8911	gtex_brain_putamen_basal
rs62036658	16	28850371	TUFM	ENSG00000178952.4	1.213E-9	7358	gtex_brain_putamen_basal
rs200502572	16	28851374	TUFM	ENSG00000178952.4	4.89E-10	6355	gtex_brain_putamen_basal
rs3088215	16	28853996	TUFM	ENSG00000178952.4	4.89E-10	3733	gtex_brain_putamen_basal
rs28403629	16	28854769	TUFM	ENSG00000178952.4	4.89E-10	2960	gtex_brain_putamen_basal
rs61737565	16	28855522	TUFM	ENSG00000178952.4	4.89E-10	2207	gtex_brain_putamen_basal
rs4788099	16	28855727	TUFM	ENSG00000178952.4	4.89E-10	2002	gtex_brain_putamen_basal
rs7187776	16	28857645	TUFM	ENSG00000178952.4	3.612E-11	84	gtex_brain_putamen_basal
rs9972693	16	28859802	TUFM	ENSG00000178952.4	4.89E-10	-2073	gtex_brain_putamen_basal
rs113079736	16	28860183	TUFM	ENSG00000178952.4	4.898E-10	-2454	gtex_brain_putamen_basal
rs12325014	16	28860237	TUFM	ENSG00000178952.4	4.89E-10	-2508	gtex_brain_putamen_basal
rs9972768	16	28861734	TUFM	ENSG00000178952.4	4.89E-10	-4005	gtex_brain_putamen_basal
rs56040780	16	28861881	TUFM	ENSG00000178952.4	4.89E-10	-4152	gtex_brain_putamen_basal
rs72793815	16	28863451	TUFM	ENSG00000178952.4	6.739E-10	-5722	gtex_brain_putamen_basal
rs80275162	16	28863517	TUFM	ENSG00000178952.4	3.171E-10	-5788	gtex_brain_putamen_basal
rs56226746	16	28864449	TUFM	ENSG00000178952.4	5.036E-9	-6720	gtex_brain_putamen_basal
rs56163509	16	28864471	TUFM	ENSG00000178952.4	3.407E-8	-6742	gtex_brain_putamen_basal
rs547990046	16	28864521	TUFM	ENSG00000178952.4	8.174E-10	-6792	gtex_brain_putamen_basal
rs4788100	16	28864673	TUFM	ENSG00000178952.4	6.484E-10	-6944	gtex_brain_putamen_basal
rs62037363	16	28865042	TUFM	ENSG00000178952.4	6.813E-10	-7313	gtex_brain_putamen_basal
rs7205323	16	28865892	TUFM	ENSG00000178952.4	4.915E-10	-8163	gtex_brain_putamen_basal
rs7187333	16	28865916	TUFM	ENSG00000178952.4	4.54E-9	-8187	gtex_brain_putamen_basal
rs147684209	16	28867061	TUFM	ENSG00000178952.4	2.891E-10	-9332	gtex_brain_putamen_basal
rs149601295	16	28867159	TUFM	ENSG00000178952.4	8.927E-9	-9430	gtex_brain_putamen_basal
rs4788101	16	28867804	TUFM	ENSG00000178952.4	4.89E-10	-10075	gtex_brain_putamen_basal
rs62037364	16	28868695	TUFM	ENSG00000178952.4	4.615E-10	-10966	gtex_brain_putamen_basal
rs62037365	16	28868962	TUFM	ENSG00000178952.4	4.89E-10	-11233	gtex_brain_putamen_basal
rs11150609	16	28870596	TUFM	ENSG00000178952.4	4.89E-10	-12867	gtex_brain_putamen_basal
rs12446589	16	28870962	TUFM	ENSG00000178952.4	4.519E-9	-13233	gtex_brain_putamen_basal
rs200424911	16	28871190	TUFM	ENSG00000178952.4	4.543E-9	-13461	gtex_brain_putamen_basal
rs12448902	16	28871191	TUFM	ENSG00000178952.4	7.92E-9	-13462	gtex_brain_putamen_basal
rs199766562	16	28871200	TUFM	ENSG00000178952.4	1.186E-9	-13471	gtex_brain_putamen_basal
rs62037366	16	28871657	TUFM	ENSG00000178952.4	4.519E-9	-13928	gtex_brain_putamen_basal
rs11859512	16	28871853	TUFM	ENSG00000178952.4	4.89E-10	-14124	gtex_brain_putamen_basal
rs11861132	16	28871860	TUFM	ENSG00000178952.4	4.89E-10	-14131	gtex_brain_putamen_basal
rs11861174	16	28871989	TUFM	ENSG00000178952.4	4.89E-10	-14260	gtex_brain_putamen_basal
rs7499337	16	28872354	TUFM	ENSG00000178952.4	4.519E-9	-14625	gtex_brain_putamen_basal
rs6565229	16	28872598	TUFM	ENSG00000178952.4	4.89E-10	-14869	gtex_brain_putamen_basal
rs4788102	16	28873398	TUFM	ENSG00000178952.4	4.89E-10	-15669	gtex_brain_putamen_basal
rs62037367	16	28874547	TUFM	ENSG00000178952.4	4.89E-10	-16818	gtex_brain_putamen_basal
rs7198606	16	28875122	TUFM	ENSG00000178952.4	4.89E-10	-17393	gtex_brain_putamen_basal
rs11864750	16	28875204	TUFM	ENSG00000178952.4	3.227E-10	-17475	gtex_brain_putamen_basal
rs7193733	16	28875482	TUFM	ENSG00000178952.4	9.432E-10	-17753	gtex_brain_putamen_basal
rs11863370	16	28879484	TUFM	ENSG00000178952.4	4.89E-10	-21755	gtex_brain_putamen_basal
rs8055982	16	28881202	TUFM	ENSG00000178952.4	4.89E-10	-23473	gtex_brain_putamen_basal
rs7498603	16	28882424	TUFM	ENSG00000178952.4	4.89E-10	-24695	gtex_brain_putamen_basal
rs7498665	16	28883241	TUFM	ENSG00000178952.4	4.89E-10	-25512	gtex_brain_putamen_basal
rs62037369	16	28883841	TUFM	ENSG00000178952.4	4.519E-9	-26112	gtex_brain_putamen_basal
rs7359397	16	28885659	TUFM	ENSG00000178952.4	4.519E-9	-27930	gtex_brain_putamen_basal
rs11864107	16	28885931	TUFM	ENSG00000178952.4	4.89E-10	-28202	gtex_brain_putamen_basal
rs3888190	16	28889486	TUFM	ENSG00000178952.4	4.89E-10	-31757	gtex_brain_putamen_basal
rs201017113	16	28889697	TUFM	ENSG00000178952.4	4.665E-9	-31968	gtex_brain_putamen_basal
rs140143522	16	28889707	TUFM	ENSG00000178952.4	5.2E-10	-31978	gtex_brain_putamen_basal
rs62037371	16	28890131	TUFM	ENSG00000178952.4	4.89E-10	-32402	gtex_brain_putamen_basal
rs8055138	16	28891465	TUFM	ENSG00000178952.4	4.696E-10	-33736	gtex_brain_putamen_basal
rs200730364	16	28893136	TUFM	ENSG00000178952.4	5.359E-9	-35407	gtex_brain_putamen_basal
rs72793818	16	28893137	TUFM	ENSG00000178952.4	5.148E-10	-35408	gtex_brain_putamen_basal
rs11645143	16	28893409	TUFM	ENSG00000178952.4	4.308E-10	-35680	gtex_brain_putamen_basal
rs11641216	16	28893532	TUFM	ENSG00000178952.4	4.457E-10	-35803	gtex_brain_putamen_basal
rs7498555	16	28893571	TUFM	ENSG00000178952.4	3.939E-9	-35842	gtex_brain_putamen_basal
rs5816477	16	28893724	TUFM	ENSG00000178952.4	3.897E-9	-35995	gtex_brain_putamen_basal
rs8061590	16	28895130	TUFM	ENSG00000178952.4	1.097E-9	-37401	gtex_brain_putamen_basal
rs11642449	16	28896015	TUFM	ENSG00000178952.4	3.281E-7	-38286	gtex_brain_putamen_basal
rs8056890	16	28897452	TUFM	ENSG00000178952.4	3.337E-7	-39723	gtex_brain_putamen_basal
rs6565259	16	28898793	TUFM	ENSG00000178952.4	4.89E-8	-41064	gtex_brain_putamen_basal
rs68040616	16	28904733	TUFM	ENSG00000178952.4	6.328E-7	-47004	gtex_brain_putamen_basal
rs9931989	16	28906084	TUFM	ENSG00000178952.4	3.348E-7	-48355	gtex_brain_putamen_basal
rs200025738	16	28910962	TUFM	ENSG00000178952.4	1.08E-6	-53233	gtex_brain_putamen_basal
rs71143703	16	28911124	TUFM	ENSG00000178952.4	1.633E-6	-53395	gtex_brain_putamen_basal
rs7189927	16	28913787	TUFM	ENSG00000178952.4	3.332E-7	-56058	gtex_brain_putamen_basal
rs8046545	16	28915217	TUFM	ENSG00000178952.4	2.648E-6	-57488	gtex_brain_putamen_basal
rs10499	16	28915527	TUFM	ENSG00000178952.4	2.648E-6	-57798	gtex_brain_putamen_basal
rs7188071	16	28917644	TUFM	ENSG00000178952.4	3.328E-7	-59915	gtex_brain_putamen_basal
rs7206214	16	28919341	TUFM	ENSG00000178952.4	2.642E-6	-61612	gtex_brain_putamen_basal
rs10653411	16	28919583	TUFM	ENSG00000178952.4	3.276E-6	-61854	gtex_brain_putamen_basal
rs7184597	16	28921809	TUFM	ENSG00000178952.4	4.681E-6	-64080	gtex_brain_putamen_basal
rs11646653	16	28922149	TUFM	ENSG00000178952.4	5.819E-7	-64420	gtex_brain_putamen_basal
rs9708958	16	28922743	TUFM	ENSG00000178952.4	5.132E-6	-65014	gtex_brain_putamen_basal
rs72420511	16	28923518	TUFM	ENSG00000178952.4	4.11E-6	-65789	gtex_brain_putamen_basal
rs68126287	16	28923520	TUFM	ENSG00000178952.4	1.482E-6	-65791	gtex_brain_putamen_basal
rs12919058	16	28927818	TUFM	ENSG00000178952.4	2.233E-7	-70089	gtex_brain_putamen_basal
rs7185232	16	28933468	TUFM	ENSG00000178952.4	7.603E-7	-75739	gtex_brain_putamen_basal
rs4072402	16	28937259	TUFM	ENSG00000178952.4	1.367E-6	-79530	gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
ARIH2	0.90	0.91
TAF1	0.89	0.91
ZC3H11A	0.89	0.90
DHX38	0.89	0.88
YEATS2	0.88	0.91
GCN1L1	0.88	0.89
SART3	0.88	0.89
DDX42	0.88	0.91
SMARCC2	0.88	0.89
CPSF7	0.88	0.90

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.31	-0.72	-0.79
IFI27	-0.71	-0.78
HIGD1B	-0.71	-0.79
MT-CO2	-0.71	-0.77
FXYD1	-0.69	-0.77
AF347015.21	-0.68	-0.79
MT-CYB	-0.66	-0.72
CST3	-0.66	-0.75
S100A16	-0.65	-0.72
AF347015.33	-0.65	-0.70

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0003746	translation elongation factor activity	IDA		9332382
GO:0003924	GTPase activity	IEA		-
GO:0005515	protein binding	IPI		17353931
GO:0005525	GTP binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006414	translational elongation	IDA		9332382
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005622	intracellular	IEA		-
GO:0005739	mitochondrion	IDA		9332382

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
ST FAS SIGNALING PATHWAY	65	54	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN	362	238	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 DN	126	86	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 2 DN	77	46	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN	162	116	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP	530	342	All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER	178	108	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
PAL PRMT5 TARGETS UP	203	135	All SZGR 2.0 genes in this pathway
JAZAERI BREAST CANCER BRCA1 VS BRCA2 UP	49	28	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 6	189	112	All SZGR 2.0 genes in this pathway
WONG MITOCHONDRIA GENE MODULE	217	122	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP	673	430	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN	593	372	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN	591	366	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002	429	260	All SZGR 2.0 genes in this pathway
MOOTHA PGC	420	269	All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA	447	277	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN	841	431	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS DURATION CORR DN	146	90	All SZGR 2.0 genes in this pathway
ALFANO MYC TARGETS	239	156	All SZGR 2.0 genes in this pathway

Gene Page: TUFM