Gene Page: WAS

Summary
GeneID  7454
Symbol  WAS
Synonyms  IMD2|THC|WASP
Description  Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
See related  HGNC:12731|MIM:300392|Ensembl:ENSG00000015285|HPRD:02314|
Locus tag  -
Gene type  protein-coding
Map location  Xp11.4-p11.21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0367 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005083small GTPase regulator activityTAS8625410 
GO:0042802identical protein bindingIPI12769847 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006461protein complex assemblyTAS8625410 
GO:0008544epidermis developmentTAS8069912 
GO:0007596blood coagulationTAS8069912 
GO:0030048actin filament-based movementIEA-
GO:0006955immune responseIMP8069912 
GO:0006952defense responseTAS8069912 
GO:0016197endosome transportIEA-
GO:0042110T cell activationIEA-
GO:0030041actin filament polymerizationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0012506vesicle membraneIEA-
GO:0005634nucleusIDA18029348 
GO:0005737cytoplasmIEA-
GO:0015629actin cytoskeletonTAS8625410 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTC1ACTC | CMD1R | CMH11actin, alpha, cardiac muscle 1-HPRD12029088 
ARPC1BARC41 | p40-ARC | p41-ARCactin related protein 2/3 complex, subunit 1B, 41kDa-HPRD11943145 
ARPC3ARC21 | p21-Arcactin related protein 2/3 complex, subunit 3, 21kDaTwo-hybridBioGRID9889097 
BTKAGMX1 | AT | ATK | BPK | IMD1 | MGC126261 | MGC126262 | PSCTK1 | XLABruton agammaglobulinemia tyrosine kinase-HPRD,BioGRID8892607 
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)CDC42 interacts with WASP. This interaction was modeled on a demonstrated interaction between CDC42 and WASP from an unspecified species.BIND15652748 
Active GTP-bound CDC42 interacts with WAS (WASP). This interaction was modelled on a demonstrated interaction between chicken CDC42 and human WAS.BIND15735674 
Cdc42 interacts with WASP.BIND15361624 
-HPRD8625410 |10724160 
in vitro
in vivo
Reconstituted Complex		BioGRID8625410 |8643625 
|10713100 |10724160 
CRKL-v-crk sarcoma virus CT10 oncogene homolog (avian)-like-HPRD,BioGRID11313252 
CrkL interacts with WASP.BIND11313252 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)Affinity Capture-WesternBioGRID9307968 
FGRFLJ43153 | MGC75096 | SRC2 | c-fgr | c-src2 | p55c-fgr | p58c-fgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homologAffinity Capture-Western
Reconstituted Complex		BioGRID8805332 |8824280 
-HPRD8824280 |10358777 
FYBADAP | PRO0823 | SLAP-130FYN binding protein (FYB-120/130)-HPRD,BioGRID10747096 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YESAffinity Capture-Western
Reconstituted Complex		BioGRID8805332 |10532312 
-HPRD8805332 |10224664 
|10532312 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2Affinity Capture-Western
Reconstituted Complex		BioGRID8805332 |9307968 
-HPRD9307968 |10224664 
HCKJTK9hemopoietic cell kinaseReconstituted ComplexBioGRID12029088 
ITKEMT | LYK | MGC126257 | MGC126258 | PSCTK2IL2-inducible T-cell kinase-HPRD,BioGRID8810341 
ITSN2KIAA1256 | PRO2015 | SH3D1B | SH3P18 | SWA | SWAPintersectin 2-HPRD,BioGRID11748279 
LCP2SLP-76 | SLP76lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)-HPRD,BioGRID10747096 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1Affinity Capture-Western
in vitro
in vivo		BioGRID7565724 |10747096 
|12135674 
-HPRD7565724 |11340081 
Nck interacts with WASp.BIND15558067 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)Affinity Capture-Western
Reconstituted Complex		BioGRID8805332 
-HPRD10358777 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1Reconstituted ComplexBioGRID8805332 |8824280 
-HPRD8892607 
PSTPIP1CD2BP1 | CD2BP1L | CD2BP1S | H-PIP | PAPAS | PSTPIPproline-serine-threonine phosphatase interacting protein 1-HPRD,BioGRID9488710 
PSTPIP1 interacts with WASP.BIND11313252 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-HPRD,BioGRID8643625 
RHOJARHJ | FLJ14445 | MGC34777 | RASL7B | TC10B | TCLras homolog gene family, member J-HPRD,BioGRID10967094 
RHOQARHQ | RASL7A | TC10 | TC10Aras homolog gene family, member QTC10 interacts with WASP.BIND15361624 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID8805332 
TECMGC126760 | MGC126762 | PSCTK4tec protein tyrosine kinase-HPRD,BioGRID8892607 
TRIP10CIP4 | HSTP | STOT | STPthyroid hormone receptor interactor 10-HPRD,BioGRID10713100 
CIP4 interacts with WASP.BIND10713100 
VASP-vasodilator-stimulated phosphoprotein-HPRD,BioGRID11598004 
WIPF1MGC111041 | PRPL-2 | WASPIP | WIPWAS/WASL interacting protein family, member 1-HPRD,BioGRID9405671 
WIP interacts with WASP.BIND12504004 
WIPF2WICH | WIREWAS/WASL interacting protein family, member 2-HPRD,BioGRID12213210 
 


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