Gene Page: XPC

Summary
GeneID  7508
Symbol  XPC
Synonyms  XP3|XPCC
Description  xeroderma pigmentosum, complementation group C
See related  HGNC:12816|MIM:278720|Ensembl:ENSG00000154767|HPRD:02046|
Locus tag  -
Gene type  protein-coding
Map location  3p25
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.006 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ZSCAN210.970.94
NVL0.950.92
TRA2A0.950.91
BAT10.950.90
SSRP10.950.90
ZNF6710.950.90
WTAP0.940.90
EPC10.940.89
SETDB10.940.92
ZNF340.940.91
Top 10 negatively co-expressed genes
HLA-F-0.74-0.74
C5orf53-0.72-0.69
AIFM3-0.72-0.74
AF347015.31-0.72-0.85
AF347015.27-0.72-0.84
PTH1R-0.72-0.73
FBXO2-0.71-0.66
MT-CO2-0.71-0.85
AF347015.33-0.70-0.82
IFI27-0.70-0.84
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003684damaged DNA bindingTAS10873465 
GO:0003697single-stranded DNA bindingTAS8168482 
GO:0005515protein bindingIPI15231747 |18024891 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000075cell cycle checkpointIMP17088560 
GO:0000718nucleotide-excision repair, DNA damage removalEXP10583946 
GO:0010224response to UV-BIEA-
GO:0031573intra-S DNA damage checkpointIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005654nucleoplasmEXP10214908 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABCA1ABC-1 | ABC1 | CERP | FLJ14958 | HDLDT1 | MGC164864 | MGC165011 | TGDATP-binding cassette, sub-family A (ABC1), member 1Reconstituted Complex
Two-hybrid		BioGRID12505994 
CETN2CALT | CEN2centrin, EF-hand protein, 2-HPRD,BioGRID11279143 
DDB2DDBB | FLJ34321 | UV-DDB2damage-specific DNA binding protein 2, 48kDaDDB2 interacts with XPC. This interaction was modeled on a demonstrated interaction between human DDB2 and hamster XPC.BIND15882621 
ERCC3BTF2 | GTF2H | RAD25 | TFIIH | XPBexcision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)-HPRD,BioGRID10734143 
LSM3SMX4 | USS2 | YLR438CLSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)-HPRD,BioGRID15231747 
RAD23AHHR23A | MGC111083RAD23 homolog A (S. cerevisiae)-HPRD,BioGRID9164480 
RAD23BHHR23B | HR23B | P58RAD23 homolog B (S. cerevisiae)-HPRD,BioGRID11279143 
TDG-thymine-DNA glycosylase-HPRD12505994 
 


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