Gene Page: XRCC5

Summary
GeneID  7520
Symbol  XRCC5
Synonyms  FLJ39089|KARP-1|KARP1|KU80|KUB2|Ku86|NFIV
Description  X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
See related  HGNC:12833|MIM:194364|Ensembl:ENSG00000079246|HPRD:08935|
Locus tag  -
Gene type  protein-coding
Map location  2q35
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00916 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01016 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003674molecular_functionND-
GO:0003677DNA bindingIEA-
GO:0003677DNA bindingNAS1537839 
GO:0003690double-stranded DNA bindingTAS7957065 
GO:0004003ATP-dependent DNA helicase activityIEA-
GO:0004003ATP-dependent DNA helicase activityTAS7957065 
GO:0005488bindingIEA-
GO:0005524ATP bindingIEA-
GO:0004386helicase activityIEA-
GO:0016787hydrolase activityIEA-
GO:0008022protein C-terminus bindingIPI10783163 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006303double-strand break repair via nonhomologous end joiningIEA-
GO:0006282regulation of DNA repairNAS9214634 
GO:0019047provirus integrationEXP16291214 
GO:0019059initiation of viral infectionEXP12091904 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005575cellular_componentND-
GO:0005634nucleusIEA-
GO:0005634nucleusTAS7957065 
GO:0005654nucleoplasmEXP12023295 |12065431 
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APEX1APE | APE-1 | APE1 | APEN | APEX | APX | HAP1 | REF-1 | REF1APEX nuclease (multifunctional DNA repair enzyme) 1Reconstituted ComplexBioGRID8621488 
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptorReconstituted ComplexBioGRID15640154 
ATMAT1 | ATA | ATC | ATD | ATDC | ATE | DKFZp781A0353 | MGC74674 | TEL1 | TELO1ataxia telangiectasia mutatedXRCC5 (Ku80) interacts with ATM.BIND15758953 
ATRFRP1 | MEC1 | SCKL | SCKL1ataxia telangiectasia and Rad3 relatedXRCC5 (Ku80) interacts with ATR.BIND15758953 
BIN1AMPH2 | AMPHL | DKFZp547F068 | MGC10367 | SH3P9bridging integrator 1Co-purificationBioGRID17671430 
CD40Bp50 | CDW40 | MGC9013 | TNFRSF5 | p50CD40 molecule, TNF receptor superfamily member 5-HPRD,BioGRID10514012 
CHEK1CHK1CHK1 checkpoint homolog (S. pombe)Affinity Capture-WesternBioGRID12756247 
HBBCD113t-Chemoglobin, betaKu80 interacts with beta-globin origin.BIND15910003 
HSF1HSTF1heat shock transcription factor 1in vitroBioGRID9325337 
KAT2AGCN5 | GCN5L2 | MGC102791 | PCAF-b | hGCN5K(lysine) acetyltransferase 2AAffinity Capture-Western
Co-fractionation		BioGRID9488450 
LMNB2LAMB2 | LMN2 | MGC2721lamin B2Ku80 interacts with Lamin B2 origin.BIND15910003 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)Ku80 interacts with C-Myc origin.BIND15910003 
NBNAT-V1 | AT-V2 | ATV | FLJ10155 | MGC87362 | NBS | NBS1 | P95nibrinNBS1 interacts with XRCC5 (Ku80).BIND15758953 
NCOA6AIB3 | ANTP | ASC2 | HOX1.1 | HOXA7 | KIAA0181 | NRC | PRIP | RAP250 | TRBPnuclear receptor coactivator 6Affinity Capture-MSBioGRID10823961 |12519782 
ORC1LHSORC1 | ORC1 | PARC1origin recognition complex, subunit 1-like (yeast)Affinity Capture-WesternBioGRID12393188 
ORC2LORC2origin recognition complex, subunit 2-like (yeast)-HPRD,BioGRID12393188 
PCNAMGC8367proliferating cell nuclear antigen-HPRD,BioGRID12393188 
POLA1DKFZp686K1672 | POLA | p180polymerase (DNA directed), alpha 1, catalytic subunit-HPRD,BioGRID12393188 
POLR2DHSRBP4 | HSRPB4 | RBP4polymerase (RNA) II (DNA directed) polypeptide DAffinity Capture-WesternBioGRID12393188 
POLR2ERPABC1 | RPB5 | XAP4 | hRPB25 | hsRPB5polymerase (RNA) II (DNA directed) polypeptide E, 25kDaAffinity Capture-WesternBioGRID12393188 
POU2F1OCT1 | OTF1POU class 2 homeobox 1Affinity Capture-WesternBioGRID11279128 |12393188 
PRIM1MGC12308 | p49primase, DNA, polypeptide 1 (49kDa)Affinity Capture-WesternBioGRID12393188 
PRKDCDNA-PKcs | DNAPK | DNPK1 | HYRC | HYRC1 | XRCC7 | p350protein kinase, DNA-activated, catalytic polypeptide-HPRD10207052 |10446239 
XRCC5 (Ku80) interacts with PRKDC (DNA-PKc).BIND15758953 
Affinity Capture-Western
in vitro
in vivo
Reconstituted Complex		BioGRID9312071 |10446239 
|12393188 
RBM14COAA | DKFZp779J0927 | MGC15912 | MGC31756 | PSP2 | SIP | SYTIP1 | TMEM137RNA binding motif protein 14-HPRD,BioGRID11443112 
RFC1A1 | MGC51786 | MHCBFB | PO-GA | RECC1 | RFC | RFC140replication factor C (activator 1) 1, 145kDaAffinity Capture-WesternBioGRID12393188 
TERF2TRBF2 | TRF2telomeric repeat binding factor 2Affinity Capture-WesternBioGRID15100233 
TERF2IPDRIP5 | RAP1telomeric repeat binding factor 2, interacting proteinAffinity Capture-MS
Affinity Capture-Western		BioGRID15100233 
TERTEST2 | TCS1 | TP2 | TRT | hEST2telomerase reverse transcriptase-HPRD,BioGRID12377759 
TOP2ATOP2 | TP2Atopoisomerase (DNA) II alpha 170kDaAffinity Capture-WesternBioGRID12393188 
TYK2JTK1tyrosine kinase 2Affinity Capture-WesternBioGRID10673353 
VAV1VAVvav 1 guanine nucleotide exchange factorAffinity Capture-WesternBioGRID10673353 
WRNDKFZp686C2056 | RECQ3 | RECQL2 | RECQL3Werner syndrome-HPRD,BioGRID12177300 
XRCC6CTC75 | CTCBF | G22P1 | KU70 | ML8 | TLAAX-ray repair complementing defective repair in Chinese hamster cells 6Affinity Capture-Western
Co-fractionation
in vitro
in vivo
Reconstituted Complex
Two-hybrid		BioGRID9488450 |10207052 
|10219089 |10446239 
|10984620 
Ku70 interacts with Ku80BIND11493912 
-HPRD10207052 |10446239 
 


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