Gene Page: ZNF165

Summary ?
GeneID7718
SymbolZNF165
SynonymsCT53|LD65|ZSCAN7
Descriptionzinc finger protein 165
ReferenceMIM:600834|HGNC:HGNC:12953|Ensembl:ENSG00000197279|HPRD:02903|Vega:OTTHUMG00000014505
Gene typeprotein-coding
Map location6p21.3
Pascal p-value2.354E-12
eGeneMeta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.033 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SYT40.780.84
SMARCA10.770.80
ZWILCH0.760.83
SLC35A10.750.79
LRRN30.750.83
HMGCR0.750.83
HMGCS10.740.84
AADAT0.740.73
TTC130.740.78
ZNF75D0.740.81
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.58-0.73
AF347015.33-0.58-0.70
AIFM3-0.58-0.64
AF347015.31-0.58-0.71
AF347015.27-0.57-0.69
MT-CYB-0.56-0.71
ZNF385A-0.56-0.65
FXYD1-0.56-0.67
AF347015.8-0.56-0.72
HLA-F-0.55-0.60

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityNAS-
GO:0005515protein bindingIPI16189514 
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentNAS-
GO:0006350transcriptionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005634nucleusNAS-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CCDC130MGC10471coiled-coil domain containing 130Affinity Capture-Western
Two-hybrid		BioGRID16189514 
CCDC85BDIPAcoiled-coil domain containing 85BTwo-hybridBioGRID16189514 
DVL2-dishevelled, dsh homolog 2 (Drosophila)Affinity Capture-Western
Two-hybrid		BioGRID16189514 
EWSR1EWSEwing sarcoma breakpoint region 1Affinity Capture-Western
Two-hybrid		BioGRID16189514 
FAM124AFLJ30707family with sequence similarity 124ATwo-hybridBioGRID16189514 
KRTAP4-12KAP4.12 | KRTAP4.12keratin associated protein 4-12Two-hybridBioGRID16189514 
MYST2HBO1 | HBOA | KAT7MYST histone acetyltransferase 2Two-hybridBioGRID16189514 
PDLIM7LMP1PDZ and LIM domain 7 (enigma)Two-hybridBioGRID16189514 
SCAND1RAZ1 | SDP1SCAN domain containing 1Two-hybridBioGRID16189514 
TCEB3BELOA2 | HsT832 | MGC119351 | TCEB3Ltranscription elongation factor B polypeptide 3B (elongin A2)Two-hybridBioGRID16189514 
ZNF192LD5-1 | ZKSCAN8zinc finger protein 192Two-hybridBioGRID10567577 
ZNF24KOX17 | RSG-A | ZNF191 | ZSCAN3 | Zfp191zinc finger protein 24Two-hybridBioGRID10567577 
ZNF250FLJ57354 | MGC111123 | MGC9718 | ZFP647 | ZNF647zinc finger protein 250Two-hybridBioGRID16189514 
ZNF446FLJ20626 | ZKSCAN20 | ZSCAN30zinc finger protein 446Two-hybridBioGRID16189514 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP 450256All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER BASAL VS MESENCHYMAL UP 12145All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY UP 7841All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA DN 284156All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL UP 316190All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530342All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP 223140All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464276All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS UP 14591All SZGR 2.0 genes in this pathway
HADDAD T LYMPHOCYTE AND NK PROGENITOR UP 7856All SZGR 2.0 genes in this pathway
SU TESTIS 7653All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419273All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP 388234All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439257All SZGR 2.0 genes in this pathway
PODAR RESPONSE TO ADAPHOSTIN UP 14798All SZGR 2.0 genes in this pathway
CHEN HOXA5 TARGETS 9HR UP 223132All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299189All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G1 UP 11370All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535325All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 7 403240All SZGR 2.0 genes in this pathway