Gene Page: CDADC1
Summary ?
| GeneID | 81602 |
| Symbol | CDADC1 |
| Synonyms | NYD-SP15|bA103J18.1 |
| Description | cytidine and dCMP deaminase domain containing 1 |
| Reference | HGNC:HGNC:20299|Ensembl:ENSG00000102543|HPRD:16693|Vega:OTTHUMG00000016913 |
| Gene type | protein-coding |
| Map location | 13q14.2 |
| Pascal p-value | 0.225 |
| Fetal beta | -0.81 |
| DMG | 1 (# studies) |
| eGene | Cerebellar Hemisphere Cerebellum |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg20136959 | 13 | 49821950 | CDADC1 | 5.5E-10 | -0.01 | 8.9E-7 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MTF1 | 0.87 | 0.87 |
| MTR | 0.86 | 0.87 |
| ETV3 | 0.85 | 0.86 |
| PPFIA1 | 0.84 | 0.84 |
| EDEM1 | 0.83 | 0.85 |
| BMP2K | 0.83 | 0.85 |
| HELZ | 0.83 | 0.83 |
| WDFY3 | 0.83 | 0.84 |
| SNX27 | 0.83 | 0.83 |
| KIAA0556 | 0.83 | 0.82 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.66 | -0.65 |
| C1orf54 | -0.61 | -0.66 |
| AF347015.31 | -0.60 | -0.58 |
| MT-CO2 | -0.59 | -0.58 |
| VAMP5 | -0.59 | -0.56 |
| IL32 | -0.58 | -0.59 |
| HIGD1B | -0.57 | -0.57 |
| GNG11 | -0.57 | -0.53 |
| IFI27 | -0.57 | -0.55 |
| AF347015.8 | -0.55 | -0.54 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| OSMAN BLADDER CANCER UP | 404 | 246 | All SZGR 2.0 genes in this pathway |
| TCGA GLIOBLASTOMA COPY NUMBER DN | 31 | 21 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS INTERMEDIATE PROGENITOR | 149 | 84 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 | 720 | 440 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |