Gene Page: PICALM

Summary
GeneID  8301
Symbol  PICALM
Synonyms  CALM|CLTH|LAP
Description  phosphatidylinositol binding clathrin assembly protein
See related  HGNC:15514|MIM:603025|Ensembl:ENSG00000073921|HPRD:04320|
Locus tag  -
Gene type  protein-coding
Map location  11q14
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CKS1B0.650.24
HIST1H4F0.640.42
HIST2H2AC0.640.24
HIST1H2AM0.630.26
HIST1H4B0.630.42
SPC250.630.18
HMGB20.630.29
CKS20.620.17
SPC240.620.31
DLGAP50.610.17
Top 10 negatively co-expressed genes
SGK1-0.19-0.20
RTBDN-0.18-0.21
PERP-0.18-0.14
GPR160-0.18-0.26
BAALC-0.18-0.17
TM4SF1-0.18-0.11
C5orf35-0.17-0.16
CCDC85B-0.17-0.14
LGI4-0.17-0.10
UNC5C-0.17-0.15
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0030276clathrin bindingIDASynap (GO term level: 4)10436022 
GO:0030276clathrin bindingISSSynap (GO term level: 4)-
GO:0005543phospholipid bindingIEA-
GO:0005545phosphatidylinositol bindingIEA-
GO:0005545phosphatidylinositol bindingISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006898receptor-mediated endocytosisIDA10436022 
GO:0006898receptor-mediated endocytosisISS-
GO:0048268clathrin coat assemblyIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusIEA-
GO:0030118clathrin coatIEA-
GO:0016020membraneIEA-
GO:0005905coated pitIDA10436022 
GO:0005905coated pitISS-
GO:0031410cytoplasmic vesicleIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AP2A1ADTAA | AP2-ALPHA | CLAPA1adaptor-related protein complex 2, alpha 1 subunit-HPRD10436022 
CASP3CPP32 | CPP32B | SCA-1caspase 3, apoptosis-related cysteine peptidase-HPRD10926122 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidase-HPRD10926122 
CLTCCHC | CHC17 | CLH-17 | CLTCL2 | Hc | KIAA0034clathrin, heavy chain (Hc)Affinity Capture-Western
Reconstituted Complex		BioGRID10436022 
DDIT3CEBPZ | CHOP | CHOP10 | GADD153 | MGC4154DNA-damage-inducible transcript 3-HPRD,BioGRID1547942 
EHD2FLJ96617 | PAST2EH-domain containing 2-HPRD15182197 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1-HPRD,BioGRID10926122 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/206524530m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-124.1120612121Ahsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-13712341240m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-142-3p8418471Ahsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-148/15211501156m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-1557737791Ahsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
hsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-181942948m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-2175165221Ahsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-23944950m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-30-5p129413011A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-3239449501Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-330887893m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-3747647701Ahsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-3848318381A,m8hsa-miR-384AUUCCUAGAAAUUGUUCAUA
hsa-miR-384AUUCCUAGAAAUUGUUCAUA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.