Gene Page: CASP7

Summary
GeneID  840
Symbol  CASP7
Synonyms  CMH-1|ICE-LAP3|MCH3
Description  caspase 7, apoptosis-related cysteine peptidase
See related  HGNC:1508|MIM:601761|Ensembl:ENSG00000165806|HPRD:03457|
Locus tag  -
Gene type  protein-coding
Map location  10q25
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0048 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CHN10.860.81
ATG70.840.82
RGS40.840.80
KIAA07480.840.73
VSNL10.830.78
OSTF10.830.73
PAH0.830.76
SMYD20.830.80
NRSN10.820.77
THEMIS0.820.74
Top 10 negatively co-expressed genes
FADS2-0.49-0.44
SH2D2A-0.49-0.55
SH3BP2-0.47-0.54
SEMA4B-0.47-0.46
SH2B2-0.46-0.50
KIAA1949-0.45-0.43
PKN1-0.45-0.43
TUBB2B-0.44-0.50
TRAF4-0.44-0.48
KCTD11-0.44-0.45
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI12665508 |12888622 
GO:0004197cysteine-type endopeptidase activityIEA-
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisIDA12888622 
GO:0006508proteolysisIEA-
GO:0006915apoptosisIEA-
GO:0008632apoptotic programTAS8576161 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP9325343 |9922454 |11257231 
GO:0005789endoplasmic reticulum membraneTAS12665508 
GO:0005737cytoplasmTAS8576161 
GO:0031966mitochondrial membraneTAS12665508 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptorAndrogen Receptor interacts with caspase 7.BIND9535906 
ATN1B37 | D12S755E | DRPLA | NODatrophin 1Atrophin-1 interacts with caspase 7.BIND9535906 
BIRC2API1 | HIAP2 | Hiap-2 | MIHB | RNF48 | cIAP1baculoviral IAP repeat-containing 2c-IAP1 interacts with caspase-7.BIND15580265 
-HPRD,BioGRID9384571 
BIRC3AIP1 | API2 | CIAP2 | HAIP1 | HIAP1 | MALT2 | MIHC | RNF49baculoviral IAP repeat-containing 3-HPRD,BioGRID9384571 
cIAP2 exhibits E3 ubiquitin ligase activity towards Casp7.BIND10862606 
BIRC5API4 | EPR-1baculoviral IAP repeat-containing 5in vitro
Reconstituted Complex		BioGRID9850056 |11170436 
-HPRD9850056 |11024045 
|11170436 
BIRC6APOLLON | BRUCE | FLJ13726 | FLJ13786 | KIAA1289baculoviral IAP repeat-containing 6BRUCE interacts with Casp-7. This interaction was modeled on a demonstrated interaction between mouse BRUCE and human Casp-7.BIND15200957 
BIRC7KIAP | LIVIN | ML-IAP | MLIAP | RNF50baculoviral IAP repeat-containing 7-HPRD,BioGRID11024045 
CASP10ALPS2 | FLICE2 | MCH4caspase 10, apoptosis-related cysteine peptidase-HPRD,BioGRID8962078 
CASP2CASP-2 | ICH-1L | ICH-1L/1S | ICH1 | NEDD2caspase 2, apoptosis-related cysteine peptidase-HPRD,BioGRID11399776 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidaseBiochemical ActivityBioGRID8962078 |11832478 
CTSGCG | MGC23078cathepsin GCatG interacts with caspase-7.BIND15650747 
DCTN1DAP-150 | DP-150 | HMN7B | P135dynactin 1 (p150, glued homolog, Drosophila)-HPRD11425872 
DSPDPI | DPIIdesmoplakin-HPRD15500642 
GORASP1FLJ23443 | GOLPH5 | GRASP65 | MGC118894 | MGC118897 | P65golgi reassembly stacking protein 1, 65kDa-HPRD11815631 
GZMBCCPI | CGL-1 | CGL1 | CSP-B | CSPB | CTLA1 | CTSGL1 | HLP | SECTgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)GraB interacts with caspase-7.BIND15650747 
HSPA5BIP | FLJ26106 | GRP78 | MIF2heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)-HPRD,BioGRID11943137 
HTTHD | IT15huntingtinHtt interacts with caspase 7.BIND14713958 
PARP1ADPRT | ADPRT1 | PARP | PARP-1 | PPOL | pADPRT-1poly (ADP-ribose) polymerase 1PARP interacts with caspase-7. This interaction was modelled on a demonstrated interaction between human PARP and fly drICE.BIND15580265 
PSEN1AD3 | FAD | PS1 | S182presenilin 1PS1 interacts with caspase 7. This interaction was modeled on a demonstrated interaction between human PS1 and mouse caspase 7.BIND10069390 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1CASP7 (caspase-7) cleaves RB-1 (hRB) at the DEAD and DSID consensus sites to produce the p68, p61 and p48 forms.BIND15735701 
RNF7CKBBP1 | ROC2 | SAGring finger protein 7-HPRD10082581 
TNFRSF1ACD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60tumor necrosis factor receptor superfamily, member 1A-HPRD,BioGRID11755217 
XIAPAPI3 | BIRC4 | ILP1 | MIHA | XLP2X-linked inhibitor of apoptosisXIAP interacts with caspase-7.BIND15580265 
-HPRD9230442 |11359776 
Caspase-7 interacts with XIAP.BIND15650747 
in vitro
in vivo
Reconstituted Complex		BioGRID9230442 |9384571 
|11257232 |11359776 
XIAP interacts with Casp-7.BIND15200957 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-23100010071A,m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-32399910061A,m8hsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-3781061121Ahsa-miR-378CUCCUGACUCCAGGUCCUGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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